Daily Archives: September 13, 2013


Author: Yu-fei Lin Background: Sequencing of the genome of Propionibacterium acnes produced a catalogue of genes many of which enable this organism to colonise skin and survive exposure to the elements. Despite this platform, there was little understanding of the gene regulation that gives rise to an organism that has […]

A combination of improved differential and global RNA-seq reveals pervasive ...


Author: Alan A Garner Background: The utility of advanced prehospital interventions for severe blunt traumatic brain injury (BTI) remains controversial. Of all trauma patient subgroups it has been anticipated that this patient group would most benefit from advanced prehospital interventions as hypoxia and hypotension have been demonstrated to be associated […]

The study protocol for the Head Injury Retrieval Trial (HIRT): ...



Author: Ning Tang Background: Coagulopathy often develops in patients with serious trauma and is correlated with the clinical outcome. The contribution of platelet activity and endothelial dysfunction to trauma-induced coagulopathy remain to be defined. The purpose of this study was to investigate the time courses of soluble P-selectin (sPsel, an […]

Time course of soluble P-selectin and von Willebrand factor levels ...




Author: Michael M Webber Background: Life history tradeoffs may result from temporal and physiological constraints intrinsic to an organism. When faced with limited time and energy, compromises occur and these resources are allocated among essential activities, such as body growth, maintenance, foraging, mating, and offspring care. We investigated potential tradeoffs […]

Reproductive tradeoff limits the predatory efficiency of female Arizona Bark ...


Author: York Zausig IntroductionRecent data suggested an interaction between plasma constituents and the endothelial glycocalyx to be relevant for vascular barrier function. This might be negatively influenced by infusion solutions, depending on ionic composition, pH and binding properties. The present study evaluated such an influence of current artificial preparations. Methods: […]

The impact of crystalloidal and colloidal infusion preparations on coronary ...



Author: Christabel C Enweronu-Laryea Background: Rotavirus immunization has been effective in developed countries where genotype G1P[8] is the predominant rotavirus strain. Knowledge of circulating strains in a population before introduction of rotavirus immunization program will be useful in evaluating the effect of the intervention. Methods: Rotavirus was identified by enzyme […]

Rotavirus genotypes associated with childhood severe acute diarrhoea in southern ...


Author: Jun Qiao Background: Akabane disease, caused by Akabane virus, is an insect-transmitted disease of ruminants that is primarily characterized by fetal damage.Methods and resultsIn this study, a novel reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for rapid detection of Akabane virus was successfully developed. The primers were designed to […]

Rapid detection of Akabane virus by a novel reverse transcription ...



Author: Jorune Balciuniene Background: External development and optical transparency of embryos make zebrafish exceptionally suitable for in vivo insertional mutagenesis using fluorescent proteins to visualize expression patterns of mutated genes. Recently developed Gene Breaking Transposon (GBT) vectors greatly improve the fidelity and mutagenicity of transposon-based gene trap vectors. Results: We […]

Efficient disruption of Zebrafish genes using a Gal4-containing gene trap


Author: Catalin Vasilescu Background: The response to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor-alpha (TNF-alpha) by innate immune cells. Cells or organisms pretreated with endotoxin enter into a transient state of hyporesponsiveness, referred to as endotoxin tolerance (ET) which represents […]

Fractal-like kinetics of intracellular enzymatic reactions: a chemical framework of ...



Author: Lotta Nybergh Background: Few population-based studies assessing IPV among randomly selected women and men have been conducted in Sweden. Hence, the aim of the current study was to explore self-reported exposure, associated factors, social and behavioral consequences of and reasons given for using psychological, physical and sexual intimate partner […]

Self-reported exposure to intimate partner violence among women and men ...


Author: Janja Zajc Background: The basidomycete Wallemia ichthyophaga from the phylogenetically distinct class Wallemiomycetes is the most halophilic fungus known to date. It requires at least 10% NaCl and thrives in saturated salt solution. To investigate the genomic basis of this exceptional phenotype, we obtained a de-novo genome sequence of […]

Genome and transcriptome sequencing of the halophilic fungus Wallemia ichthyophaga: ...



Author: Rafat A Siddiqui Background: The major obstacles to the successful use of individual nutritional compounds as preventive or therapeutic agents are their efficacy and bioavailability. One approach to overcoming this problem is to use combinations of nutrients to induce synergistic effects. The objective of this research was to investigate […]

Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin ...


Author: Jiazhou Wang Background: Accurate target localization is mandatory in the accelerated partial breast irradiation (APBI) delivery. Dosimetric verification for positional error will further guarantee the accuracy of treatment delivery. The purpose of this study is to evaluate the clinical feasibility of a cone beam computer tomographic (CBCT) image correction […]

Using corrected Cone-Beam CT image for accelerated partial breast irradiation ...



Author: Lindsay Macdonald Background: Diabetes is a major health issue for individuals and for health services. There is a considerable literature on the management of diabetes and also on communication in primary care consultations. However, few studies combine these two topics and specifically in relation to nurse communication. This paper […]

Nurse-patient communication in primary care diabetes management: an exploratory study


Author: Kimberly Yolton Background: National data suggest widespread gestational exposure to organophosphate pesticides (OPs) based on the detection of OP metabolites in the urine of pregnant women. Associations with early infant neurobehavior are largely understudied, with only two studies reporting abnormal reflexes in newborns in association with gestational exposure to […]

An observational study measuring the impact low-level gestational exposure to ...




Author: Sangita Sharma Background: Stroke is the fourth leading cause of death in the U.S. and stroke mortality rates differ substantially by ethnic group. The impact of adherence to the USDA dietary guidelines on risk for fatal stroke among different ethnic groups has not previously been examined. Methods: A prospective […]

Adherence to the USDA dietary recommendations for fruit and vegetable ...



Author: Hans-Dieter Volk Several data support the view that impairment of the inflammatory-immune response is a hallmark of severe sepsis and the level and time of recovery to immunocompetence has a major impact on the clinical outcome of ICU patients. Recent studies demonstrate that improvement of anti-tumour immune response by […]

To be, or not to be immunocompetent


Author: Olivier Dameron Background: Clinical trials are important for patients, for researchers and for companies. One of the major bottlenecks is patient recruitment. This task requires the matching of a large volume of information about the patient with numerous eligibility criteria, in a logically-complex combination. Moreover, some of the patient’s […]

OWL model of clinical trial eligibility criteria compatible with partially-known ...