Daily Archives: April 22, 2014


Author: Michael Schuler Backround: To examine whether lack of measurement invariance (MI) influences mean comparisons among different disease groups, this paper provides (1) a systematic review of MI in generic constructs across chronic conditions and (2) an empirical analysis of MI in the Health Education Impact Questionnaire (heiQTM). Methods: (1) […]

Measurement invariance across chronic conditions: a systematic review and an ...


Author: Marja Moerkens Background: Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER) alpha -positive breast cancer patients. Although the mechanisms behind tamoxifen resistance are still not completely understood, clinical data suggests that increased expression of receptor tyrosine kinases is involved. Here, we studied the estrogen […]

Epidermal growth factor receptor signalling in human breast cancer cells ...



Author: Manuel Revilla Background: Fat content and fatty acid composition in swine are becoming increasingly studied because of their effect on sensory and nutritional quality of meat. A QTL (quantitative trait locus) for fatty acid composition in backfat was previously detected on porcine chromosome 8 (SSC8) in an Iberian x […]

New insight into the SSC8 genetic determination of fatty acid ...


Author: Xinyang Hu Background: The endosteum of the bone marrow provides a specialized hypoxic niche that may serve to preserve the integrity, pluripotency, longevity and stemness of resident mesenchymal stem cells (MSCs). To explore the molecular genetic consequences of such a niche we subjected human (h) MSCs to a pO2 […]

Severe hypoxia exerts parallel and cell-specific regulation of gene expression ...



Author: Brijesh Kumar Mishra Background: Human health risk assessment from exposure to disinfection by-products (DBPs) during drinking and bathing water vary from country to country as per life expectancy, body mass index, water consumption pattern and individual concentration of DBPs component, etc. Methods: Present study considered average direct water intake […]

Human health risk analysis from disinfection by-products (DBPs) in drinking ...


Author: Changsheng He Backgrounds: Extracorporeal membrane oxygenation (ECMO) has been recommended for treatment of acute, potentially reversible, life-threatening respiratory failure unresponsive to conventional therapy. Intestinal mucosal barrier dysfunction is one of the most critical pathophysiological disorders during ECMO. This study aimed to determine whether combination with CRRT could alleviate damage […]

Effects of continuous renal replacement therapy on intestinal mucosal barrier ...



Author: Kousuke Onoue Background: Prolonged re-exposure to a fear-eliciting cue in the absence of an aversive event extinguishes the fear response to the cue, and has been clinically used as an exposure therapy. Arc (also known as Arg3.1) is implicated in synaptic and experience-dependent plasticity. Arc is regulated by the […]

Fear extinction requires Arc/Arg3.1 expression in the basolateral amygdala


Author: Piraporn Utachee Background: The CD4 binding site (CD4bs) of envelope glycoprotein (Env) gp120 is a functionally conserved, important target of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. Two neutralizing human monoclonal antibodies, IgG1 b12 (b12) and VRC01, are broadly reactive neutralizing antibodies which recognize conformational epitopes that overlap […]

Impact of amino acid substitutions in the V2 and C2 ...



Author: Nikolai V Kuznetsov Background: Glucocorticoids (GCS) remain one of the mainstay treatments in the management of ulcerative colitis (UC) but up to a third of patients will ultimately fail to respond and progress to a more severe and difficult to manage disease state. Previous clinical studies suggest that the […]

Biomarkers can predict potential clinical responders to DIMS0150 a toll-like ...


Author: Hiroko Komatsu Background: With a paradigm shift toward a chronic care model in cancer, the issue of adherence is becoming increasingly important in oncology. Methods: We mailed two self-reported surveys on current nursing practices for patients on oral chemotherapy to all 309 designated cancer centers and 141 large general […]

Current nursing practice for patients on oral chemotherapy: a multicenter ...



Author: Heather D Ritter Background: While glucocorticoids and the liganded glucocorticoid receptor (GR) have a well-established role in the maintenance of differentiation and suppression of apoptosis in breast tissue, the involvement of unliganded GR in cellular processes is less clear. Our previous studies implicated unliganded GR as a positive regulator […]

Expression microarray identifies the unliganded glucocorticoid receptor as a regulator ...