Daily Archives: May 15, 2014


Author: Camille Bismuth Background: Subarachnoid cysts are rare conditions in veterinary medicine, associated with spinal cord dysfunction. Most of the 100 cases of subarachnoid cysts described since the first report in 1968 were apparently not true cysts. True cysts are usually situated in the cervical area and occur in predisposed […]

Original surgical treatment of thoracolumbar subarachnoid cysts in six chondrodystrophic ...


Author: Tsung-I Chen Background: Intermittent hypoxia (IH) plays a critical role in sleep breathing disorder-associated hippocampus impairments, including neurocognitive deficits, irreversible memory and learning impairments. IH-induced neuronal injury in the hippocampus may result from reduced precursor cell proliferation and the relative numbers of postmitotic differentiated neurons. However, the mechanisms underlying […]

Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation ...



Author: Nilimesh Halder Background: A vaccine matched to a newly emerged pandemic influenza virus would require a production time of at least 6 months with current proven techniques, and so could only be used reactively after the peak of the pandemic. A pre-pandemic vaccine, although probably having lower efficacy, could […]

A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness


Author: Gaute Reier Jenssen Background: Public awareness of hemolytic-uremic syndrome (HUS), especially related to Shiga toxin producing Escherichia coli (STEC), has increased in Europe in recent years; accentuated in Norway by a national outbreak in 2006 and in a European context especially by the 2011 outbreak originating in Germany. As […]

Incidence and etiology of hemolytic-uremic syndrome in children in Norway, ...



Author: Tim A Kanters Background: Infantile Pompe disease is a rare metabolic disease. Patients generally do not survive the first year of life. Enzyme replacement therapy (ERT) has proven to have substantial effects on survival in infantile Pompe disease. However, the costs of therapy are very high. In this paper, […]

Cost-effectiveness of enzyme replacement therapy with alglucosidase alfa in classic-infantile ...


Author: Johannes Thome Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This "progress" of molecular psychiatry, however, is to a degree "unilateral" and "epiphytic" should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of […]

Decennium of Karl Jaspers's general psychopathology: implications for molecular psychiatry



Author: Michael Liebrenz Background: Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with high rates of comorbid substance use disorders, and cigarette smoking has a particularly high prevalence in this population. However, there is an ongoing debate as to whether this tobacco use is an attempt at "self-medication" or due to behavioral […]

Adult attention-deficit/hyperactivity disorder and nicotine use: a qualitative study of ...


Author: Vittorio Fortino Background: Inferring operon maps is crucial to understanding the regulatory networks of prokaryotic genomes. Recently, RNA-seq based transcriptome studies revealed that in many bacterial species the operon structure vary with the change of environmental conditions. Therefore, new computational solutions that use both static and dynamic data are […]

Transcriptome dynamics-based operon prediction in prokaryotes



Author: Sonia Shah Background: HIV-1 gene expression is driven by the long terminal repeat (LTR), which contains many binding sites shown to interact with an array of host and viral factors. Selective pressures within the host as well as the low fidelity of reverse transcriptase lead to changes in the […]

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide ...


Author: Rosario M Piro Background: Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes’ interactions on which a pathway’s cellular function depends. In contrast, PathWave has been developed for the analysis of high-throughput gene expression data that explicitly […]

Network topology-based detection of differential gene regulation and regulatory switches ...



Author: Kristin Pogoda Background: Gap junctional calcium signal propagation (transfer of calcium or a calcium releasing messenger via gap junctions) between vascular cells has been shown to be involved in the control of vascular tone. We have shown before that nitric oxide (NO) inhibits gap junctional communication in HeLa cells […]

NO, via its target Cx37, modulates calcium signal propagation selectively ...


Author: Jitendra Kanodia Background: The Fibroblast Growth Factor (FGF) pathway is driving various aspects of cellular responses in both normal and malignant cells. One interesting characteristic of this pathway is the biphasic nature of the cellular response to some FGF ligands like FGF2. Specifically, it has been shown that phenotypic […]

Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic ...