Daily Archives: May 16, 2014


Author: Ryan van Laar Background: Widespread adoption of genomic technologies in the management of heterogeneous indications, including Multiple Myeloma, has been hindered by concern over variation between published gene expression signatures, difficulty in physician interpretation and the challenge of obtaining sufficient genetic material from limited patient specimens. Methods: Since 2006, […]

Translating a gene expression signature for multiple Myeloma prognosis into ...


Author: Xin Xu Background: Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still unknown. Methods: Quantitative RT-PCR was used to quantify miR-182-5p expression in RCC clinical tissues. Bisulfite […]

Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via ...







Author: David Westergaard Background: Epidemiological studies in the recent years have investigated the relationship between dietary habits and disease risk demonstrating that diet has a direct effect on public health. Especially plant-based diets -fruits, vegetables and herbs- are known as a source of molecules with pharmacological properties for treatment of […]

Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction ...



Author: Mitsunori Higuchi Background: Video-assisted thoracic surgery (VATS) lobectomy is a standard treatment for lung cancer. This study retrospectively compared long-term outcomes after VATS lobectomy versus lobectomy via open thoracotomy for clinical stage IA non-small cell lung cancer (NSCLC). Methods: From July 2002 to June 2012, 160 patients were diagnosed […]

Long-term outcomes after video-assisted thoracic surgery (VATS) lobectomy versus lobectomy ...


Author: Kangsheng Tu Background: The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation. However, the clinical significance of Fbxw7 and the mechanisms involved in the anti-cancer effect of Fbxw7 in HCC are not clear.MethodThe Fbxw7 and YAP expression […]

Fbxw7 is an independent prognostic marker and induces apoptosis and ...



Author: Tran Ngoc Dang Background: Dengue shock syndrome (DSS), a severe life-threatening form of dengue infection, mostly occurs in children. A recent genome wide association study (GWAS) identified two SNPs, rs3132468 of major histocompatibility complex class I polypeptide-related sequence B (MICB) and rs3765524 of phospholipase C, epsilon 1 (PLCE1), associated […]

A replication study confirms the association of GWAS-identified SNPs at ...


Author: Natali Navarro Background: Hepatitis B virus (HBV) infection is prevalent in Asian immigrants in the USA. California’s Inland Empire region has a population of approximately four million, including an estimated 19,000 first generation Koreans. Our aim was to screen these adult individuals to establish HBV serological diagnoses, educate, and […]

Lower than expected hepatitis B virus infection prevalence among first ...