Cancer


Author: Sjoerd Elias Background: The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are – in hindsight – unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications. We developed a diagnostic strategy to better exclude SCD in these […]

Is there an added value of faecal calprotectin and haemoglobin ...


Author: Rong Zhou A novel ubiquitin-like antitumour protein (RBUP) was isolated from fruiting bodies of the edible mushroom Ramaria botrytis. The protein was isolated with a purification protocol involving ion exchange chromatography on DEAE-Sepharose fast flow and gel filtration on Sephadex G-75. SDS-PAGE, Native-PAGE and ultracentrifugation analysis disclosed that RBUP […]

Purification and characterization of a novel ubiquitin-like antitumour protein with ...



Author: Lin Shi Background: Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study was to investigate the function of miRNA-146a (miR-146a) in DDP-resistant non-small cell lung cancer (NSCLC), as […]

Up-regulation of miR-146a increases the sensitivity of non-small cell lung ...







Author: S. Schwarz Background: Despite our growing knowledge about the pathomechanisms of cancer cachexia, a whole clinical picture of the cachectic patient is still missing. Our objective was to evaluate the clinical characteristics in cancer patients with and without cachexia to get the whole picture of a cachectic patient. Methods: […]

The clinical picture of cachexia: a mosaic of different parameters ...


Author: Jaya Bhandari Background: There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have investigated the anticancer potential of plant Allium wallichii, a plant native to Nepal […]

Study of phytochemical, anti-microbial, anti-oxidant, and anti-cancer properties of Allium ...



Author: Zachary Gersey Background: Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation […]

Curcumin decreases malignant characteristics of glioblastoma stem cells via induction ...


Author: Abdullah Obaid Rhazya stricta is a unique medicinal plant source for many indole alkaloids, non-alkaloids, flavonoids, triterpenes and other unknown molecules with tremendous potential for therapeutic applications against many diseases. In the present article, we generated computational data on predictive properties and activity across two key therapeutic areas of […]

Cheminformatics studies to analyze the therapeutic potential of phytochemicals from ...




Author: Hege Henriksen Background: Colorectal cancer survivors are not only at risk for recurrent disease but also at increased risk of comorbidities such as other cancers, cardiovascular disease, diabetes, hypertension and functional decline. In this trial, we aim at investigating whether a diet in accordance with the Norwegian food-based dietary […]

The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: ...



Author: Hanneke Poort Background: Fatigue is a common and debilitating symptom for patients with incurable cancer receiving systemic treatment with palliative intent. There is evidence that non-pharmacological interventions such as graded exercise therapy (GET) or cognitive behaviour therapy (CBT) reduce cancer-related fatigue in disease-free cancer patients and in patients receiving […]

Study protocol of the TIRED study: a randomised controlled trial ...




Author: Qingguo Li Background: The effect of adjuvant radiotherapy on the survival outcomes of patients with mucinous rectal cancer remains unclear. This study evaluated the 5-year cause specific survival (CSS) of patients with mucinous rectal cancer after surgery to determine whether adjuvant radiotherapy conferred a survival benefit. Methods: An analysis […]

Adjuvant radiotherapy improves cause specific survival in stage II, not ...


Author: Raymond Chan Cancer survivorship is being increasingly recognized as an important component of cancer care. This commentary reviews the key findings reported in the recent BMC Medicine publication of the ACTION study, which focuses on the health-related quality of life and psychological distress in 5249 cancer survivors in eight […]

A step forward in addressing cancer survivorship in the Asia-Pacific ...






Author: Nelli Roininen Background: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. Methods: We collected retrospectively patients with NEBC from Oulu […]

Primary neuroendocrine breast carcinomas are associated with poor local control ...


Author: Cláudia Coutinho-Camillo Background: Oral squamous cell carcinoma (OSCC) is the eighth most prevalent cancer worldwide. In recent large-scale studies, by immunohistochemistry and cluster analysis, several markers were associated with patient survival in various tumors. The aim of this study was to analyze the expression profiles of 23 proteins that […]

Profile of apoptotic proteins in oral squamous cell carcinoma: A ...




Author: Youn Cho Background: One-lung ventilation during thoracic surgery frequently disturbs normal systemic oxygenation. However, the effect of anesthetics on arterial oxygenation during one-lung ventilation has not been well established in human study. In this clinical trial, we investigated whether a difference between desflurane-remifentanil and propofol-remifentanil anesthesia can be observed […]

Effect of desflurane-remifentanil vs. Propofol-remifentanil anesthesia on arterial oxygenation during ...



Author: Julia Escandon Background: Immune checkpoint inhibitors have become the first line therapy in melanoma treatment and their use is extending to other malignancies. However, we are still learning about immune side effects produced by these drugs and their severity especially in patients with history of inflammatory diseases.Case presentationWe present […]

Interstitial nephritis in melanoma patients secondary to PD-1 checkpoint inhibitor


Author: Gilda Hillman Background: We previously demonstrated that tumor irradiation potentiates cancer vaccines using genetic modification of tumor cells in murine tumor models. To investigate whether tumor irradiation augments the immune response to MUC1 tumor antigen, we have tested the efficacy of tumor irradiation combined with an MVA-MUC1-IL2 cancer vaccine […]

Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity ...