Lympatic Disorders


Author: Wei Lin Background: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a multisystem fibroinflammatory disease. We previously reported that a circulating cell population expressing CD19 + CD24 − CD38 hi was increased in patients with IgG4-RD. In this study, we aimed to document that this cell population represented circulating plasmablasts/plasma cells, […]

Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease




Author: Jaya Bhandari Background: There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have investigated the anticancer potential of plant Allium wallichii, a plant native to Nepal […]

Study of phytochemical, anti-microbial, anti-oxidant, and anti-cancer properties of Allium ...


Author: Nelli Roininen Background: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. Methods: We collected retrospectively patients with NEBC from Oulu […]

Primary neuroendocrine breast carcinomas are associated with poor local control ...



Author: Md. Fakruddin Background: Probiotic yeast has become a field of interest to scientists in recent years. Methods: Conventional cultural method was employed to isolate and identify yeast and standard methods were used to determine different probiotic attributes, antimicrobial and antioxidant properties. Results: This study reports potential probiotic properties of […]

Antimicrobial and antioxidant activities of Saccharomyces cerevisiae IFST062013, a potential ...


Author: Cheng-Che Tu Background: Pathological response is an important marker for tumor aggressiveness in patients with esophageal squamous cell carcinoma (ESCC) who receive preoperative chemoradiation followed by esophagectomy. We aim to evaluate the prognostic value of histological factors after trimodality treatments. Methods: 91 patients who received preoperative chemoradiation followed by […]

Prognostic histological factors in patients with esophageal squamous cell carcinoma ...



Author: Kathryn Beckermann Background: Renal medullary carcinoma (RMC) is a rare kidney tumor that occurs in adolescent and young adults, typically in association with sickle cell trait. RMC exhibits rapid disease progression, frequent metastases at diagnosis, and dismal clinical outcomes. Currently available therapies, including cisplatin-based combination chemotherapy, multi-tyrosine kinase, and […]

Clinical and immunologic correlates of response to PD-1 blockade in ...


Author: The ACTION Study Group Background: A better understanding of health-related quality of life (HRQoL) and psychological distress in cancer survivors can raise awareness, promote the development of policies in cancer survivorship care, and facilitate better targeted use of limited resources in low- and middle-income countries (LMICs). The main objectives […]

Health-related quality of life and psychological distress among cancer survivors ...



Author: M. Jebali Background: Metabolic toxicities of mTOR inhibitors (mTORi) are well characterized. The purpose of the study was to investigate the relationship between these metabolic toxicities and mTORi efficacy. Methods: From 2007 to 2011, metabolic toxicities were retrospectively collected in patients treated with an mTORi (everolimus, temsirolimus) for a […]

Biological toxicities as surrogate markers of efficacy in patients treated ...


Author: James Kuzman Background: Immunotherapy with high-dose interleukin-2 (HD-IL2) results in long-term survival in some metastatic renal cell carcinoma (mRCC) patients but has significant acute toxicities. Biomarkers predicting response to therapy are needed to better select patients most likely to benefit. NLR (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) is […]

Neutrophil-lymphocyte ratio as a predictive biomarker for response to high ...




Author: Toshihiko Kohashi Background: Intra-abdominal lymphangiomas are rare, benign tumors in adults. This report is the third documented case of a lymphangioma originating in the hepatoduodenal ligament that mimicked a simple liver cyst.Case presentationA 50-year-old woman was admitted with a cystic tumor in the right lobe of her liver and […]

An adult case of lymphangioma of the hepatoduodenal ligament mimicking ...



Author: Ning Wu Background: Body mass index (BMI), resting energy expenditure (REE) and fasting blood glucose (FBG) are major preoperative assessments of patients’ nutrition and metabolic state. The relations and effects of these indices on esophageal cancer patients’ postoperative short-term and long-term outcomes remain controversial and unclear. We aimed to […]

The prognostic influence of body mass index, resting energy expenditure ...


Author: Faye Cooles Background: Alemtuzumab, an anti-CD52 monoclonal antibody, was administered to patients with RA between 1991 and 1994. We have followed a cohort of recipients since that time and previously reported significant delays in immune reconstitution. Here we report >20 years of follow-up data from this unique cohort.MethodSurviving alemtuzumab recipients […]

Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid ...



Author: Tycel Phillips The T-cell lymphoproliferative disorders are a heterogeneous group of non-Hodgkin’s lymphomas (NHL) for which current therapeutic strategies are inadequate, as most patients afflicted with these NHL will succumb to disease progression within 2 years of diagnosis. Appreciation of the genetic and immunologic landscape of these aggressive NHL, […]

Challenges and opportunities for checkpoint blockade in T-cell lymphoproliferative disorders


Author: Michael Gitlin Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently. Although this observation is multifactorial, one obvious potential contributor is the side effect and toxicity burden associated with lithium. Additionally, side effect concerns assuredly play some […]

Lithium side effects and toxicity: prevalence and management strategies



Author: Emily Williams Background: Glucocorticoids (GCs) remain the first line treatment for almost all non-infectious inflammatory diseases, ranging from acute asthma to rheumatoid arthritis. However, across all conditions, patients have a variable response to GCs with approximately 30% being non-responders. This group of GC resistant patients is typically exposed to […]

Development and validation of a novel bioassay to determine glucocorticoid ...


Author: Gustavo Cuck Background: Muscle invasive bladder cancer (BC) has a mortality rate of 50% in 5 years, despite the aggressive treatments currently used. The diagnosis of latent tumor cells in histologically normal lymph nodes (LN) may have prognostic value and may explain the tumoral recurrence in BC. Methods: Here we […]

Diagnosis of micrometastasis in muscle invasive bladder cancer through immunohistochemistry ...



Author: Jonas Demeulemeester Background: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in […]

Tracing the origin of disseminated tumor cells in breast cancer ...


Author: Itsuro Kazama In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributing substantially to the pathogenesis of the disease. Despite our understanding of the molecular mechanisms by which lymphocytes are activated, we know little […]

Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: ...



Author: Hui Miao Background: CancerMath is a set of web-based prognostic tools which predict nodal status and survival up to 15 years after diagnosis of breast cancer. This study validated its performance in a Southeast Asian setting. Methods: Using Singapore Malaysia Hospital-Based Breast Cancer Registry, clinical information was retrieved from 7064 […]

Validation of the CancerMath prognostic tool for breast cancer in ...


Author: Wang-Dong Zhang Background: The neonatal Fc receptor (FcRn) plays a crucial role in transporting IgG and associated antigens across polarized epithelial barriers in mucosal immunity. However, it was not clear that FcRn expression in aggregated lymphoid nodules area (ALNA) in abomasum, a unique and important mucosal immune structure discovered […]

Localization of neonatal Fc receptor for IgG in aggregated lymphoid ...



Author: Jamal El-Saghir Background: Exosomes are membrane nano-vesicles secreted by a multitude of cells that harbor biological constituents such as proteins, lipids, mRNA and microRNA. Exosomes can potentially transfer their cargo to other cells, implicating them in many patho-physiological processes. Mesenchymal stem cells (MSCs), residents of the bone marrow and […]

ATL-derived exosomes modulate mesenchymal stem cells: potential role in leukemia ...


Author: MacLean Hall Background: We evaluated whether tumor infiltrating lymphocytes (TIL) could be expanded from surgically resected tumors from pancreatic cancer patients. Methods: Tumors were resected from pancreatic cancer patients. Tumors were minced into fragments and cultured in media containing high dose interleukin-2 (IL-2) for up to 6 weeks. T cell […]

Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors