Adrenocortical Carcinoma


Author: Liang-Ru Ke Background: Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is now the standard strategy […]

Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line ...




Author: Qingguo Li Background: The effect of adjuvant radiotherapy on the survival outcomes of patients with mucinous rectal cancer remains unclear. This study evaluated the 5-year cause specific survival (CSS) of patients with mucinous rectal cancer after surgery to determine whether adjuvant radiotherapy conferred a survival benefit. Methods: An analysis […]

Adjuvant radiotherapy improves cause specific survival in stage II, not ...


Author: Nelli Roininen Background: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. Methods: We collected retrospectively patients with NEBC from Oulu […]

Primary neuroendocrine breast carcinomas are associated with poor local control ...



Author: Cláudia Coutinho-Camillo Background: Oral squamous cell carcinoma (OSCC) is the eighth most prevalent cancer worldwide. In recent large-scale studies, by immunohistochemistry and cluster analysis, several markers were associated with patient survival in various tumors. The aim of this study was to analyze the expression profiles of 23 proteins that […]

Profile of apoptotic proteins in oral squamous cell carcinoma: A ...


Author: Cheng-Che Tu Background: Pathological response is an important marker for tumor aggressiveness in patients with esophageal squamous cell carcinoma (ESCC) who receive preoperative chemoradiation followed by esophagectomy. We aim to evaluate the prognostic value of histological factors after trimodality treatments. Methods: 91 patients who received preoperative chemoradiation followed by […]

Prognostic histological factors in patients with esophageal squamous cell carcinoma ...



Author: Gilda Hillman Background: We previously demonstrated that tumor irradiation potentiates cancer vaccines using genetic modification of tumor cells in murine tumor models. To investigate whether tumor irradiation augments the immune response to MUC1 tumor antigen, we have tested the efficacy of tumor irradiation combined with an MVA-MUC1-IL2 cancer vaccine […]

Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity ...


Author: Kathryn Beckermann Background: Renal medullary carcinoma (RMC) is a rare kidney tumor that occurs in adolescent and young adults, typically in association with sickle cell trait. RMC exhibits rapid disease progression, frequent metastases at diagnosis, and dismal clinical outcomes. Currently available therapies, including cisplatin-based combination chemotherapy, multi-tyrosine kinase, and […]

Clinical and immunologic correlates of response to PD-1 blockade in ...



Author: M. Jebali Background: Metabolic toxicities of mTOR inhibitors (mTORi) are well characterized. The purpose of the study was to investigate the relationship between these metabolic toxicities and mTORi efficacy. Methods: From 2007 to 2011, metabolic toxicities were retrospectively collected in patients treated with an mTORi (everolimus, temsirolimus) for a […]

Biological toxicities as surrogate markers of efficacy in patients treated ...


Author: Clemens Tempfer Background: Primary advanced, unresectable ovarian cancer (OC) is treated with palliative systemic chemotherapy. Intraperitoneal chemotherapy may be an alternative local maintenance therapy.Case presentationA 75 year old woman with laparoscopically and histologically confirmed unresectable OC was treated with 13 cycles of intraperitoneal cisplatin 7.5 mg/m 2 and doxorubicin […]

Intraperitoneal cisplatin and doxorubicin as maintenance chemotherapy for unresectable ovarian ...



Author: Yuanyuan Xiao Background: The prognostic role of pretreatment serum lactate dehydronegase (LDH) has been well established in many malignant tumors, albeit it remains under-discussed in pancreatic cancer. In the present study, we aimed to assess the association between baseline LDH levels and overall survival (OS) in advanced pancreatic ductal […]

Prognostic relevance of lactate dehydrogenase in advanced pancreatic ductal adenocarcinoma ...


Author: James Kuzman Background: Immunotherapy with high-dose interleukin-2 (HD-IL2) results in long-term survival in some metastatic renal cell carcinoma (mRCC) patients but has significant acute toxicities. Biomarkers predicting response to therapy are needed to better select patients most likely to benefit. NLR (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) is […]

Neutrophil-lymphocyte ratio as a predictive biomarker for response to high ...



Author: Leung Li Background: Health-related quality-of-life (HRQOL) assessment with EORTC QLQ-C30 was prognostic for overall survival (OS) in patients with advance-stage hepatocellular carcinoma (HCC), but no data existed for early-stage patients. The HCC-specific QLQ-HCC18 has not been evaluated for prognostic value in HCC patients. Utilization of raw HRQOL data in […]

Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients ...


Author: Shosuke Kawanishi Infection and chronic inflammation have been recognized as important factors for carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) and […]

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation ...




Author: Victor Kuete Background: Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases. Methods: This study was designed to investigate the cytotoxicity of 14 naturally occurring quinones including; 3 anthraquinones, 1 naphthoquinone and 10 benzoquinones against 6 human […]

Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones ...



Author: Yi An Current adjuvant treatment guidelines for oropharyngeal squamous cell carcinoma treated with primary surgery are based on studies that predate the human papillomavirus (HPV) era. HPV-associated oropharynx carcinoma (HPV-OPC) has a much more favorable prognosis compared to HPV-unassociated cancer and is increasingly considered to be a distinct disease […]

De-intensification of adjuvant therapy in human papillomavirus-associated oropharyngeal cancer




Author: Daris Ferrari Background: Oropharyngeal cancer is frequently associated with human papilloma virus, that also represents a strong prognostic factor. Local relaps and treatment-related complications are frequent, whereas distant metastases occur in about 25% of patients.Case presentationA 49 years-old male presented with a loco-regionally advanced oropharyngeal squamous cell carcinoma and was […]

An unusual case of tracheo-pleural fistula and cardiac metastases in ...


Author: A. Talhouk Endometrial carcinoma (EC) is the fourth most common cancer in women in the developed world. Classification of ECs by histomorphologic criteria has limited reproducibility and better tools are needed to distinguish these tumors and enable a subtype-specific approach to research and clinical care. Based on the Cancer […]

New classification of endometrial cancers: the development and potential applications ...



Author: R. Hofheinz Background: Decisions on palliative chemotherapy (CT) for locally advanced or metastatic gastric cancer (mGC) require trade-offs between potential benefits and risks for patients. Healthcare providers and payers agree that patient-preferences should be considered. We conducted a choice-based conjoint (CBC) analysis study in pre-treated patients from Germany with […]

Patient preferences for palliative treatment of locally advanced or metastatic ...


Author: Serghei Malkov Background: Several studies have shown that mammographic texture features are associated with breast cancer risk independent of the contribution of breast density. Thus, texture features may provide novel information for risk stratification. We examined the association of a set of established texture features with breast cancer risk […]

Mammographic texture and risk of breast cancer by tumor type ...



Author: Teng Huang Background: Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant factor that limits the efficacy of radiotherapy for NPC patients. Growing evidence supports that microRNAs (miRNAs) […]

MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis