Breast Cancer


Author: Jaya Bhandari Background: There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have investigated the anticancer potential of plant Allium wallichii, a plant native to Nepal […]

Study of phytochemical, anti-microbial, anti-oxidant, and anti-cancer properties of Allium ...


Author: Nelli Roininen Background: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. Methods: We collected retrospectively patients with NEBC from Oulu […]

Primary neuroendocrine breast carcinomas are associated with poor local control ...



Author: Parisa Tehranifar Background: Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammographic density, a […]

Early life socioeconomic environment and mammographic breast density


Author: Yu Lu Background: CYP2E1 polymorphisms have been reported to influence individual’s breast cancer susceptibility as a phase I enzyme, but the results of these previous studies remain controversial. We performed a comprehensive meta-analysis to assess their association. Methods: A comprehensive search of literature included in various databases (PubMed, Web […]

Role of CYP2E1 polymorphisms in breast cancer: a systematic review ...



Author: Shlomit Shachar Background: Discordance in hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) status between primary tumors and metastatic sites for breast cancer is well established. However, it is uncertain which patient-related factors lead to biopsy when metastases are suspected and whether having a biopsy impacts […]

Biopsy of breast cancer metastases: patient characteristics and survival


Author: Raffaella Comitato Background: We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a specific binding and activation of the estrogen receptor-β (ERβ). Transcriptomic data obtained […]

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer ...



Author: Marion Kiechle Background: Women with highly penetrant BRCA mutations have a 55–60% lifetime risk for breast cancer and a 16–59% lifetime risk for ovarian cancer. However, penetrance differs interindividually, indicating that environmental and behavioral factors may modify this risk. These include lifestyle factors such as physical activity status, dietary […]

Lifestyle intervention in BRCA1/2 mutation carriers: study protocol for a ...


Author: Edith Perez Background: Pertuzumab, trastuzumab, and docetaxel is standard of care for first-line treatment of HER2-positive metastatic breast cancer (MBC). However, alternative chemotherapy partners are required to align with patient/physician preferences and to increase treatment flexibility. We report VELVET Cohort 1 results in which the efficacy and safety of […]

Safety and efficacy of vinorelbine in combination with pertuzumab and ...



Author: Jonas Demeulemeester Background: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in […]

Tracing the origin of disseminated tumor cells in breast cancer ...


Author: Serghei Malkov Background: Several studies have shown that mammographic texture features are associated with breast cancer risk independent of the contribution of breast density. Thus, texture features may provide novel information for risk stratification. We examined the association of a set of established texture features with breast cancer risk […]

Mammographic texture and risk of breast cancer by tumor type ...



Author: Frank Lin Background: Multidisciplinary team (MDT) meetings are used to optimise expert decision-making about treatment options, but such expertise is not digitally transferable between centres. To help standardise medical decision-making, we developed a machine learning model designed to predict MDT decisions about adjuvant breast cancer treatments. Methods: We analysed […]

Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer ...


Author: Cecilia Huo Background: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could […]

Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive ...



Author: Hui Miao Background: CancerMath is a set of web-based prognostic tools which predict nodal status and survival up to 15 years after diagnosis of breast cancer. This study validated its performance in a Southeast Asian setting. Methods: Using Singapore Malaysia Hospital-Based Breast Cancer Registry, clinical information was retrieved from 7064 […]

Validation of the CancerMath prognostic tool for breast cancer in ...


Author: Susan Farabaugh Background: ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signaling. For example, ErbB2 inhibitors can block IGF-induced signaling while, conversely, IGF1R inhibitors can inhibit ErbB2 action. ErbB […]

Lack of interaction between ErbB2 and insulin receptor substrate signaling ...



Author: F. Fjeldheim Background: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs […]

Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling ...


Author: André Hennigs Background: In Germany, most breast cancer patients are treated in specialized breast cancer units (BCU), which are certified, and routinely monitored. Herein, we evaluate up-to-date oncological outcome of breast cancer (BC) molecular subtypes in routine clinical care of a specialized BCU. Methods: The study was a prospectively […]

Prognosis of breast cancer molecular subtypes in routine clinical care: ...




Author: Ann Flores PurposeWe describe impairments after breast cancer and its treatment for African American (AA), non-Hispanic white and low-income breast cancer survivors (BCS) and whether physical therapy (PT) was utilized to address these impairments. Methods: BCS from the Southern Community Cohort Study (SCCS) were surveyed about self-reported BC treatment-related […]

Physical impairments and physical therapy services for minority and low-income ...



Author: Luis Martinez Background: Breast cancer is a complex heterogeneous disease where many distinct subtypes are found. Younger African American (AA) women often present themselves with aggressive form of breast cancer with unique biology which is very difficult to treat. Better understanding the biology of AA breast tumors could lead […]

Increased sensitivity of African American triple negative breast cancer cells ...


Author: Ningning He Background: Microenvironment is being increasingly recognized as a critical determinant in tumor progression and metastasis. However, the appropriate regulatory mechanism to maintain the normal balance between differentiation and self-renewal of the cancer cell in microenvironment is not well known. Methods: 4T1 breast cancer cells were treated with […]

Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast ...



Author: Camile Fontelles Background: Although males contribute half of the embryo’s genome, only recently has interest begun to be directed toward the potential impact of paternal experiences on the health of offspring. While there is evidence that paternal malnutrition may increase offspring susceptibility to metabolic diseases, the influence of paternal […]

Paternal programming of breast cancer risk in daughters in a ...




Author: My-Nuong Nguyen Background: Nam Dia Long (NDL) is a Vietnamese traditional formula used for the treatment of some chronic diseases, including cancers, but which lacks evidence-based support. We investigated the selective cytotoxicity of NDL on some tumor cell lines and possible interactions among its ingredients leading to the overall […]

Selective cytotoxicity of a Vietnamese traditional formula, Nam Dia long, ...


Author: Rikke Langballe Background: Treatment with tamoxifen or chemotherapy reduces the risk of contralateral breast cancer (CBC). However, it is uncertain how long the protection lasts and whether the protective effect is modified by patient, tumor, or treatment characteristics. Methods: The population-based WECARE Study included 1521 cases with CBC and […]

Systemic therapy for breast cancer and risk of subsequent contralateral ...