Immunologic Disorders


Author: Sjoerd Elias Background: The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are – in hindsight – unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications. We developed a diagnostic strategy to better exclude SCD in these […]

Is there an added value of faecal calprotectin and haemoglobin ...




Author: Xiaoming Yao Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies targeting aquaporin-4 (AQP4-IgG) on astrocytes. We reported evidence previously, using CD59 −/− mice, that the membrane-associated complement inhibitor […]

Marked central nervous system pathology in CD59 knockout rats following ...


Author: Charles Eaton Background: The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA). Methods: We conducted a prospective cohort study of skin advanced glycation endproducts (sAGEs) measured non-invasively by skin intrinsic fluorescence and the […]

Sex differences in the association of skin advanced glycation endproducts ...



Author: Marius Mbiantcha Background: Rheumatoid arthritis, disease of unknown causes is a rheumatic and autoimmune pathology, recognised for its increasing frequency and its adverse consequences. It is a disease that occurs in most cases between 50 and 60 years and women are more affected than men. This study aimed at […]

Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in ...


Author: Wei Lin Background: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a multisystem fibroinflammatory disease. We previously reported that a circulating cell population expressing CD19 + CD24 − CD38 hi was increased in patients with IgG4-RD. In this study, we aimed to document that this cell population represented circulating plasmablasts/plasma cells, […]

Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease



Author: Celestina Mazzotta Background: Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on ECs, including antioxidant and vasculoprotective activities. On the EC surface, sKl interacts with vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) […]

Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular ...


Author: Theodoros Dimitroulas Background: Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by high CVD mortality and morbidity. ADMA and SDMA levels are abnormal in RA […]

Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and ...



Author: Masako Tsukamoto Background: Three different subsets of circulating human monocytes, CD14 bright CD16- (classical), CD14 bright CD16+ (intermediate), and CD14 dim CD16+ (non-classical) have been recently identified. It has been reported that CD14 bright CD16+ monocytes are increased in rheumatoid arthritis (RA). However, the role of each monocyte subset […]

CD14 ...




Author: Hanan Al Rayes Background: Electrocardiogram (ECG) cardiovascular disease (CVD) abnormalities (ECG-CVD) are predictive of subsequent CVD events in the general population. Systemic lupus erythematosus (SLE) patients are vulnerable to CVD. We aimed to determine the prevalence of ECG-CVD in SLE patients and to examine the risk factors associated with […]

Prevalence and associated factors of resting electrocardiogram abnormalities among systemic ...


Author: Sultana Hussain Background: Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim of this study was to examine the relationship between body composition and LBP intensity […]

Fat mass and fat distribution are associated with low back ...



Author: Gui Tran Background: Ultrasound is increasingly used to evaluate shoulder pain, but the benefits of this are unclear. In this study, we examined whether ultrasound-defined pathologies have implications for clinical outcomes. Methods: We extracted reported pathologies from 3000 ultrasound scans of people with shoulder pain referred from primary care. […]

Ultrasound-detected pathologies cluster into groups with different clinical outcomes: data ...




Author: Kyla Hildebrand The Addendum Guidelines for the Prevention of Peanut Allergy in the United States—Report of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies demonstrated the benefit of early introduction of allergenic foods. These landmark studies including the Learning Early […]

Primum non nocere—first do no harm. And then feed peanut


Author: Zachary Gersey Background: Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 months. Theorized cause of disease recurrence in these patients is tumor cell repopulation through the proliferation […]

Curcumin decreases malignant characteristics of glioblastoma stem cells via induction ...



Author: Khan Mubashir Background: In ayurvedic traditional medicine Gentiana kurroo Royle (family; Gentianaceae) is used to treat several metabolic diseases. This plant is rich in various compounds belonging to flavonoids and glycosides. Till now little work has been carried out on immunomodulatory and anti-inflammatory potential of this plant. This study […]

Anti-inflammatory and immuno-modulatory studies on LC-MS characterised methanol extract of ...


Author: Carla Mucignat Background: Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs. We investigated whether the drug MPTP produces the olfactory deficits typical of Parkinson and affects the olfactory bulb in mice.FindingsLesioned and control mice were tested […]

Drug-induced Parkinson’s disease modulates protein kinase A and Olfactory Marker ...



Author: Lara Aqrawi Background: There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren’s syndrome (pSS) patients. Incorporation of additional diagnostics involving screening for disease-specific biomarkers in biological fluid is a promising concept that requires further investigation. In the current study we aimed to explore […]

Identification of potential saliva and tear biomarkers in primary Sjögren’s ...


Author: Li-Chung Chiu Background: The survival predictors and optimal mechanical ventilator settings in patients with severe acute respiratory distress syndrome (ARDS) undergoing extracorporeal membrane oxygenation (ECMO) are uncertain. This study was designed to investigate the influences of clinical variables and mechanical ventilation settings on the outcomes for severe ARDS patients […]

Dynamic driving pressure associated mortality in acute respiratory distress syndrome ...




Author: Yasumori Izumi Background: Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheumatoid arthritis (RA) patients at risk for infections. We hypothesized that PPSV23 vaccination is superior in preventing pneumococcal […]

The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: ...



Author: Noriko Inada Background: Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious […]

Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case


Author: Nelli Roininen Background: Breast carcinomas with neuroendocrine features (NEBC) are a very rare entity of mammary neoplasms, WHO classification of which has recently been revised. There are very limited data available about the clinical behaviour and treatment options of NEBC. Methods: We collected retrospectively patients with NEBC from Oulu […]

Primary neuroendocrine breast carcinomas are associated with poor local control ...