Medical Research





Author: Thaila dos Reis Background: The conversion of lignocellulosic biomass to biofuels (second-generation biofuel production) is an environmentally friendlier alternative to petroleum-based energy sources. Enzymatic deconstruction of lignocellulose, catalyzed by filamentous fungi such as Aspergillus nidulans, releases a mixture of mono- and polysaccharides, including hexose (glucose) and pentose (xylose) sugars, […]

Identification and characterization of putative xylose and cellobiose transporters in ...


Author: Todd Nebesio Background: Little is known about the comparative effects of different glucocorticoids on the adrenal and growth hormone (GH) axes in children with congenital adrenal hyperplasia (CAH). We sought to compare the effects of hydrocortisone (HC), prednisone (PDN), and dexamethasone (DEX) in children with classic CAH and to […]

Differential effects of hydrocortisone, prednisone, and dexamethasone on hormonal and ...






Author: Yong Wang We design an axiomatization for reversible computation called reversible ACP (RACP). It has four extendible modules: basic reversible processes algebra, algebra of reversible communicating processes, recursion and abstraction. Just like process algebra ACP in classical computing, RACP can be treated as an axiomatization foundation for reversible computation. […]

An algebra of reversible computation


Author: Sjoerd Elias Background: The majority of primary care patients referred for bowel endoscopy do not have significant colorectal disease (SCD), and are – in hindsight – unnecessarily exposed to a small but realistic risk of severe endoscopy-associated complications. We developed a diagnostic strategy to better exclude SCD in these […]

Is there an added value of faecal calprotectin and haemoglobin ...



Author: Pier Buttigieg Background: The Environment Ontology (ENVO; http://www.environmentontology.org/), first described in 2013, is a resource and research target for the semantically controlled description of environmental entities. The ontology’s initial aim was the representation of the biomes, environmental features, and environmental materials pertinent to genomic and microbiome-related investigations. However, the […]

The environment ontology in 2016: bridging domains with increased scope, ...








Author: L. Montrose Background: Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or hyper-methylation have been shown to occur in response to environmental exposures including dietary nutrients. Methods: Within the […]

Dietary intake is associated with respiratory health outcomes and DNA ...




Author: Nancy Komape Background: Tuberculosis is an infectious communicable disease and the causative agent of the disease has over the years developed resistance to streamline chemotherapeutic agents with dire consequences and there is a need for development of new and more potent alternatives. Methods: Constituents of leaves material of Combretum […]

Anti-mycobacteria potential and synergistic effects of combined crude extracts of ...



Author: Hendrik Helmerhorst Background: Although oxygen is generally administered in a liberal manner in the perioperative setting, the effects of oxygen administration on dynamic cardiovascular parameters, filling status and cerebral perfusion have not been fully unraveled. Our aim was to study the acute hemodynamic and microcirculatory changes before, during and […]

Hemodynamic effects of short-term hyperoxia after coronary artery bypass grafting


Author: S. Brabant Background: Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare.Case presentationWe report a case of serious anaphylactic reaction occurring after a first intraoperative injection of thymoglobulin […]

An avoidable cause of thymoglobulin anaphylaxis



Author: Shams Khan Organic compounds from plants are an attractive alternative to conventional antimicrobial agents. Therefore, two compounds namely M-1 and M-2 were purified from Origanum vulgare L. and were identified as carvacrol and thymol, respectively. Antimicrobial and antibiofilm activities of these compounds along with chlorhexidine digluconate using various assays […]

Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce ...


Author: Mei-Ling Liu Background and objectiveGonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae. Rapid detection is crucial for effective prevention and treatment. This study developed and tested a low-cost effective method for detecting N. gonorrhoeae, especially in developing countries. Methods: DNA from a N. gonorrhoeae standard […]

Loop-mediated isothermal amplification of Neisseria gonorrhoeae porA pseudogene: a rapid ...



Author: Elena Dragioti Background: Insomnia is a major cause of concern in the elderly with and without pain. This study set out to examine the insomnia and its correlates in a large sample of community adults aged ≥65 years. Methods: A cross-sectional postal survey was completed by 6205 older individuals (53.8% […]

Insomnia severity and its relationship with demographics, pain features, anxiety, ...


Author: Stéphane Gaudry Background: The recent demonstration of prone position’s strong benefit on patient survival has rendered proning a major therapeutic intervention in severe ARDS. Uncertainties remain as to whether or not ARDS patients in the postoperative period of abdominal surgery should be turned prone because of the risk of […]

Prone positioning in acute respiratory distress syndrome after abdominal surgery: ...



Author: Rong Zhou A novel ubiquitin-like antitumour protein (RBUP) was isolated from fruiting bodies of the edible mushroom Ramaria botrytis. The protein was isolated with a purification protocol involving ion exchange chromatography on DEAE-Sepharose fast flow and gel filtration on Sephadex G-75. SDS-PAGE, Native-PAGE and ultracentrifugation analysis disclosed that RBUP […]

Purification and characterization of a novel ubiquitin-like antitumour protein with ...