Respiratory System



Author: Thaila dos Reis Background: The conversion of lignocellulosic biomass to biofuels (second-generation biofuel production) is an environmentally friendlier alternative to petroleum-based energy sources. Enzymatic deconstruction of lignocellulose, catalyzed by filamentous fungi such as Aspergillus nidulans, releases a mixture of mono- and polysaccharides, including hexose (glucose) and pentose (xylose) sugars, […]

Identification and characterization of putative xylose and cellobiose transporters in ...



Author: Todd Nebesio Background: Little is known about the comparative effects of different glucocorticoids on the adrenal and growth hormone (GH) axes in children with congenital adrenal hyperplasia (CAH). We sought to compare the effects of hydrocortisone (HC), prednisone (PDN), and dexamethasone (DEX) in children with classic CAH and to […]

Differential effects of hydrocortisone, prednisone, and dexamethasone on hormonal and ...





Author: L. Montrose Background: Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or hyper-methylation have been shown to occur in response to environmental exposures including dietary nutrients. Methods: Within the […]

Dietary intake is associated with respiratory health outcomes and DNA ...



Author: Nancy Komape Background: Tuberculosis is an infectious communicable disease and the causative agent of the disease has over the years developed resistance to streamline chemotherapeutic agents with dire consequences and there is a need for development of new and more potent alternatives. Methods: Constituents of leaves material of Combretum […]

Anti-mycobacteria potential and synergistic effects of combined crude extracts of ...


Author: S. Brabant Background: Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare.Case presentationWe report a case of serious anaphylactic reaction occurring after a first intraoperative injection of thymoglobulin […]

An avoidable cause of thymoglobulin anaphylaxis



Author: Shams Khan Organic compounds from plants are an attractive alternative to conventional antimicrobial agents. Therefore, two compounds namely M-1 and M-2 were purified from Origanum vulgare L. and were identified as carvacrol and thymol, respectively. Antimicrobial and antibiofilm activities of these compounds along with chlorhexidine digluconate using various assays […]

Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce ...


Author: Mei-Ling Liu Background and objectiveGonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae. Rapid detection is crucial for effective prevention and treatment. This study developed and tested a low-cost effective method for detecting N. gonorrhoeae, especially in developing countries. Methods: DNA from a N. gonorrhoeae standard […]

Loop-mediated isothermal amplification of Neisseria gonorrhoeae porA pseudogene: a rapid ...



Author: Stéphane Gaudry Background: The recent demonstration of prone position’s strong benefit on patient survival has rendered proning a major therapeutic intervention in severe ARDS. Uncertainties remain as to whether or not ARDS patients in the postoperative period of abdominal surgery should be turned prone because of the risk of […]

Prone positioning in acute respiratory distress syndrome after abdominal surgery: ...


Author: Karar Ahsan Background: Bangladesh urban population is expected to overtake rural population by 2040, and a significant part of the increase will be in slums. Wide disparities between urban slums and the rest of the country can potentially push country indicators off track unless the specific health and nutrition […]

Effects of individual, household and community characteristics on child nutritional ...




Author: Marius Mbiantcha Background: Rheumatoid arthritis, disease of unknown causes is a rheumatic and autoimmune pathology, recognised for its increasing frequency and its adverse consequences. It is a disease that occurs in most cases between 50 and 60 years and women are more affected than men. This study aimed at […]

Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in ...



Author: Lin Shi Background: Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study was to investigate the function of miRNA-146a (miR-146a) in DDP-resistant non-small cell lung cancer (NSCLC), as […]

Up-regulation of miR-146a increases the sensitivity of non-small cell lung ...


Author: Liang-Ru Ke Background: Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Platinum-based systemic chemotherapy has shown survival benefits and is now the standard strategy […]

Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line ...






Author: Giovanni Guaraldi Background: Late presentation (LP) at the time of HIV diagnosis is defined as presentation with AIDS whatever the CD4 cell count or with CD4 <350 cells/mm. The objective of our study was to assess the prevalence of non-infectious comorbidities (NICM) and multimorbidity among HIV-positive individuals with and without […]

Late presentation increases risk and costs of non-infectious comorbidities in ...


Author: Solomon Tesfay Background: Fish are perishable and hence susceptible to high post-harvest losses. Post-harvest losses in fisheries include material losses of fish due to spoilage, breakage, size, discarding of by-catches and operational losses. This research was conducted to propose a management strategy to reduce post-harvest losses suffered by Tekeze […]

Assessment of fish post-harvest losses in Tekeze dam and Lake ...



Author: S. Schwarz Background: Despite our growing knowledge about the pathomechanisms of cancer cachexia, a whole clinical picture of the cachectic patient is still missing. Our objective was to evaluate the clinical characteristics in cancer patients with and without cachexia to get the whole picture of a cachectic patient. Methods: […]

The clinical picture of cachexia: a mosaic of different parameters ...


Author: Pedro Pallangyo Background: Cardiorenal anemia syndrome (CRAS) is an evolving global epidemic associated with increased morbimortality and cost of care. The management of patients with CRAS remains a challenging undertaking worldwide and the lack of evidence-based clinical guidelines adds to the challenge. We aimed to explore the prevalence and […]

Cardiorenal Anemia Syndrome and Survival among Heart Failure Patients in ...



Author: Jessica Jones Background: Interruptions are common in the healthcare setting. This experimental study compares the effects of interruptions on simulated performances of central venous catheterization during a highly versus minimally complex portion of the task. Methods: Twenty-six residents were assigned to interruptions during tasks that are (1) highly complex: […]

An experimental study on the impact of clinical interruptions on ...