Lung Cancer


Author: Lin Shi Background: Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study was to investigate the function of miRNA-146a (miR-146a) in DDP-resistant non-small cell lung cancer (NSCLC), as […]

Up-regulation of miR-146a increases the sensitivity of non-small cell lung ...


Author: Youn Cho Background: One-lung ventilation during thoracic surgery frequently disturbs normal systemic oxygenation. However, the effect of anesthetics on arterial oxygenation during one-lung ventilation has not been well established in human study. In this clinical trial, we investigated whether a difference between desflurane-remifentanil and propofol-remifentanil anesthesia can be observed […]

Effect of desflurane-remifentanil vs. Propofol-remifentanil anesthesia on arterial oxygenation during ...



Author: The ACTION Study Group Background: A better understanding of health-related quality of life (HRQoL) and psychological distress in cancer survivors can raise awareness, promote the development of policies in cancer survivorship care, and facilitate better targeted use of limited resources in low- and middle-income countries (LMICs). The main objectives […]

Health-related quality of life and psychological distress among cancer survivors ...


Author: Victor Kuete Background: Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases. Methods: This study was designed to investigate the cytotoxicity of 14 naturally occurring quinones including; 3 anthraquinones, 1 naphthoquinone and 10 benzoquinones against 6 human […]

Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones ...



Author: Toshimichi Miya Background: Chemotherapy-induced nausea and vomiting (CINV) is a major adverse toxicity of cancer chemotherapy. Recommended treatments for prevention of CINV vary among published guidelines, and optimal care for CINV caused by moderately emetogenic chemotherapy has not been established. This study assessed the efficacy and safety of triple […]

Efficacy of triple antiemetic therapy (palonosetron, dexamethasone, aprepitant) for chemotherapy-induced ...


Author: Bin-Chi Liao The first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (1/2G EGFR-TKIs) gefitinib, erlotinib, and afatinib have all been approved as standard first-line treatments for advanced EGFR mutation-positive non-small cell lung cancer. The third-generation (3G) EGFR-TKIs have been developed to overcome the EGFR T790M mutation, which […]

Update on recent preclinical and clinical studies of T790M mutant-specific ...




Author: Jason Roszik Background: While clinical outcomes following immunotherapy have shown an association with tumor mutation load using whole exome sequencing (WES), its clinical applicability is currently limited by cost and bioinformatics requirements. Methods: We developed a method to accurately derive the predicted total mutation load (PTML) within individual tumors […]

Novel algorithmic approach predicts tumor mutation load and correlates with ...



Author: Louisa Béchohra Background: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and apoptogenic effects on cancer […]

Cytotoxic activity of Androctonus australis hector venom and its toxic ...


Author: Bridgette Kanz Background: Anti-PD-1 therapy is increasingly used in various advanced malignancies. Patients with baseline organ dysfunction are largely excluded from clinical trials. Therefore it is unclear whether anti-PD-1 therapy is safe or effective in this setting. Further, these patients are often not candidates for other anti-cancer therapies, highlighting […]

Safety and efficacy of anti-PD-1 in patients with baseline cardiac, ...



Author: Marlon Rebelatto Background: A high-quality programmed cell-death ligand 1 (PD-L1) diagnostic assay may help predict which patients are more likely to respond to anti-programmed cell death-1 (PD-1)/PD-L1 antibody-based cancer therapy. Here we describe a PD-L1 immunohistochemical (IHC) staining protocol developed by Ventana Medical Systems Inc. and key analytical parameters […]

Development of a programmed cell death ligand-1 immunohistochemical assay validated ...


Author: Xiaocheng Cao Background: Cancer stem cells (CSCs) are considered as the origin of tumor relapse. Here, we investigated the effects of Fructus Viticis total flavonoids (FVTF) on the characteristics of lung cancer stem-like cells (LCSLCs) derived from human small cell lung cancer NCI-H446 cell line and its potential mechanism. […]

A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like ...



Author: Bakir Mehić Background: Lung cancer is usually presented with cough, dyspnea, pain and weight loss, which is overlapping with symptoms of other lung diseases such as pulmonary fibrosis. Pulmonary fibrosis shows characteristic reticular and nodular pattern, while lung cancers are mostly presented with infiltrative mass, thick-walled cavitations or a […]

Lung adenocarcinoma mimicking pulmonary fibrosis-a case report


Author: Lichun Ma Background: Epidermal growth factor receptor (EGFR) mutation-induced drug resistance is a difficult problem in lung cancer treatment. Studying the molecular mechanisms of drug resistance can help to develop corresponding treatment strategies and benefit new drug design. Methods: In this study, Rosetta was employed to model the EGFR […]

Identifying EGFR mutation-induced drug resistance based on alpha shape model ...



Author: Chen-Yue Qian Background: Platinum-based chemotherapy is the first-line treatment of non-small cell lung cancer (NSCLC); it is therefore important to discover biomarkers that can be used to predict the efficacy and toxicity of this treatment. Four important transporter genes are expressed in the kidney, including organic cation transporter 2 […]

Associations of genetic polymorphisms of the transporters organic cation transporter ...


Author: Ashutosh Dubey Background: Owing to the use of tobacco and the consumption of alcohol and adulterated food, worldwide cancer incidence is increasing at an alarming and frightening rate. Since the last decade of the twentieth century, lung cancer has been the most common cancer type. This study aimed to […]

Epidemiology of lung cancer and approaches for its prediction: a ...



Author: Changhong Zhao Background: HM-3 is a polypeptide inhibiting angiogenesis. Recent reports suggest that the antitumor effect of angiogenesis inhibitors administered alone might be limited. Cancer stem cells can survive the lack of oxygen and nutrients. To achieve better anti-tumor effect, HM-3 was administered in combination with the attenuated Salmonella […]

Enhanced therapeutic effect of an antiangiogenesis peptide on lung cancer ...


Author: Luping Zhang Background: The combination of dendritic cells (DCs) and cytokine-induced killer cells (CIKs) can induce the anti-tumor immune response and radiotherapy may promote the activity. We aimed to explore the feasibility of DCs/CIKs combined with thoracic radiotherapy (TRT) for patients with locally advanced or metastatic non-small-cell lung cancer […]

Feasibility study of DCs/CIKs combined with thoracic radiotherapy for patients ...



Author: Stephen Gavett Background: Human exposure to Libby amphibole (LA) asbestos increases risk of lung cancer, mesothelioma, and non-malignant respiratory disease. This study evaluated potency and time-course effects of LA and positive control amosite (AM) asbestos fibers in male F344 rats following nose-only inhalation exposure. Methods: Rats were exposed to […]

Persistent effects of Libby amphibole and amosite asbestos following subchronic ...


Author: Yan Sun Background: Extensive-disease small-cell lung cancer (ED-SCLC) is characterized by rapid progression and relapse, despite high initial response rates to chemotherapy. The primary objective of this trial was to demonstrate the non-inferiority of amrubicin and cisplatin (AP) combination therapy compared with the standard first-line regimen of etoposide and […]

Randomized phase III trial of amrubicin/cisplatin versus etoposide/cisplatin as first-line ...



Author: Fan Yang Background: The appropriateness of lobectomy for all elderly patients is controversial. Meanwhile, sublobar resection is associated with reduced operative risk, better preservation of pulmonary function, and a better quality of life, constituting a potential alternative to standard lobectomy for elderly patients with early-stage non-small cell lung cancer […]

Sublobar resection versus lobectomy in Surgical Treatment of Elderly Patients ...


Author: Hisashi Tanaka Background: Lung cancers with anaplastic lymphoma kinase rearrangements are highly sensitive to anaplastic lymphoma kinase tyrosine kinase inhibition, underscoring the notion that such cancers are addicted to anaplastic lymphoma kinase activity. Several anaplastic lymphoma kinase inhibitors have been identified and are being evaluated in clinical trials. However […]

Dramatic response to alectinib in a patient of ALK-rearranged lung ...



Author: Yijun Tian Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung cancer remain unsatisfied. Recent studies revealed high-frequency alteration of Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-like factor 2 (Keap1/Nrf2) pathway […]

Emerging roles of Nrf2 signal in non-small cell lung cancer


Author: Neli Slavova-Azmanova Background: Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on clinical practice is unclear. This study aimed to determine the impact of the introduction of endobronchial ultrasound-guided procedures (EBUS) on […]

Impact of the introduction of EBUS on time to management ...