Adrenocortical Carcinoma


Author: Kelong Ma Background: Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon are unclear. Methods: miR-638 and SRY-box 2 (SOX2) expression levels were detected in 36 tumor samples and their […]

Loss of miR-638 in vitro promotes cell invasion and a ...


Author: Ning Wen Background: The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expression levels of FOXM1 in epithelial ovarian cancer (EOC), to identify the relationship between FOXM1 […]

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell ...



Author: Thomas Mücke Background: The evidence base to inform the decision making process in patients with early stage oral cancer and a clinical and radiological N0 neck remains insufficient to answer the question when it is safe to "watch and wait" and when to proceed with a selective neck dissection. […]

Incidence and outcome for patients with occult lymph node involvement ...


Author: Xin Xu Background: Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still unknown. Methods: Quantitative RT-PCR was used to quantify miR-182-5p expression in RCC clinical tissues. Bisulfite […]

Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via ...



Author: Rosario M Piro Background: Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes’ interactions on which a pathway’s cellular function depends. In contrast, PathWave has been developed for the analysis of high-throughput gene expression data that explicitly […]

Network topology-based detection of differential gene regulation and regulatory switches ...


Author: Ruijin Shao Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of anti-cancer action in the endometrium of women with polycystic ovary syndrome (PCOS) have not yet been fully elucidated. Organic […]

Direct effects of metformin in the endometrium: a hypothetical mechanism ...



Author: Hung-Hsin Lin This report presents a case of collision tumors of low-grade B-cell lymphoma and adenocarcinoma in the sigmoid colon of an 81-year-old man. All surgically resected regional mesenteric lymph nodes were found to be occupied by low-grade B-cell lymphoma, and one lymph node showed the presence of adenocarcinoma. […]

Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis ...


Author: Agnieszka K Witkiewicz A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant aspects of breast cancer biology, spanning early stage lesions to targeted treatment of metastatic disease. In ductal carcinoma in situ, multiple groups have shown […]

Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, ...



Author: Shuji Kitahara Background: Vasohibin-2 (VASH2) has been identified as an endogenous and vascular endothelial growth factor (VEGF)-independent angiogenic factor that is highly expressed in tumor cells. In the present study, we aimed to determine whether pre-existing vascular changes can be used to predict tumor transformation as benign or malignant. […]

Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing ...


Author: Yuqiao Zhou Purpose: Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1alpha gene single nucleotide polymorphisms (SNPs) are implicated to be associated with cancer risks. However, results from the published studies remained inconclusive. The aim of this study is to investigate the […]

The association between hypoxia-inducible factor-1 alpha gene G1790A polymorphism and ...



Author: Tetsuji Terazawa Background: In Japan, transarterial infusion chemotherapy using cisplatin (CDDP-TAI) is frequently used for advanced hepatocellular carcinoma (HCC). Moreover, oral chemotherapy with S-1, an oral fluoropyrimidine derivative, has also elicited promising responses in HCC patients. We determined the recommended dosage for CDDP-TAI plus S-1 combination therapy for advanced […]

Transarterial infusion chemotherapy with cisplatin plus S-1 for hepatocellular carcinoma ...


Author: Zhijian Han Background: We aimed to evaluate the feasibility and clinical significance of using a modified liver-mobilization technique to treat renal cell carcinoma (RCC) combined with intrahepatic inferior vena cava (IVC) thrombosis. Methods: A total of 11 level III thrombus patients underwent radical nephrectomy with resection of the tumor […]

Modified liver mobilization for the treatment of renal cell carcinoma ...



Author: Britta Weber Background: Lung cancer patients with mutations in the epidermal growth factor receptor (EGFR) are primary candidates for EGFR-targeted therapy. Reliable analyses of such mutations have previously been possible only in tumour tissue. Here, we demonstrate that mutations can be detected in plasma samples with allele-specific PCR assays. […]

Detection of EGFR mutations in plasma and biopsies from non-small ...


Author: Chang Xian Li Background: Surgical therapies are the first-line treatments for hepatocellular carcinoma (HCC) patients. However, the high incidence of tumor metastasis after liver surgery remains a severe problem. We aim to investigate the roles and the underlying mechanism of YQ23, stabilized non-polymeric diaspirin cross-linked tetrameric hemoglobin, in liver […]

A novel oxygen carrier "YQ23" suppresses the liver tumor metastasis ...



Author: Lei Chen Background: Bile duct adenoma (BDA) is a comparatively rare disease clinically, therefore, there are relatively few reported cases about it both in China and abroad.Case presentationHerein, we present a 51-year-old man, diagnosed preoperatively with enhanced-contrast abdominal computed tomography, as having a nodule in the left hepatic. The […]

Bile duct adenoma: a case report and literature review


Author: Emanuele Felli Right colon cancer rarely presents as an emergency, in which bowel occlusion and massive bleeding are the most common clinical presentations. Although there are no definite guidelines, the first line treatment for massive right colon cancer bleeding should ideally stop the bleeding using endoscopy or interventional radiology, […]

Robotic right colectomy for hemorrhagic right colon cancer: a case ...



Author: Wei Sun Background: T regulatory cells (Tregs) contribute to the progression of head and neck squamous cell carcinoma (HNSCC) by suppressing antitumor immunity. However, little is known regarding the functional heterogeneity of Tregs in HNSCC patients. Methods: Using multicolor flow cytometry, the frequency of three Treg subsets, separated on […]

CD45RA-Foxp3high but not CD45RA+Foxp3low suppressive T regulatory cells increased in ...


Author: Weiping Huang Leukemoid reaction is defined as reactive leukocytosis exceeding 40 x 109/l, with a significant increase in early neutrophil precursors, and can be a paraneoplastic manifestation of various malignant tumors. Leukemoid reaction is a sign for poor prognosis in solid tumors so is sarcomatoid renal cell carcinoma (SRCC) […]

Leukemoid reaction in sarcomatoid renal cell carcinoma: a two-case report



Author: Aycan Akca Background: In recent years, many advances in pancreatic surgery have been achieved. Nevertheless, the rate of pancreatic fistula following pancreatic tail resection does not differ between various techniques, still reaching up to 30% in prospective multicentric studies. Taking in account contradictory results concerning the usefulness of covering […]

Is the covering of the resection margin after distal pancreatectomy ...


Author: Shaojie Jiang ObjectiveTo evaluate the efficacy and safety of adjuvant IFN therapy for viral hepatitis-related hepatocellular carcinoma (HCC) after treatment with surgical resection or transarterial chemoembolization (TACE). Methods: Controlled trials of adjuvant treatment with IFN for patients with HCC published between 2000 and 2012 were searched electronically in MEDLINE, […]

A meta-analysis and systematic review: adjuvant interferon therapy for patients ...



Author: Eiji Mitate Background: Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare.Case report: A 55-year-old male patient presented with an asymptomatic mass of the upper lip that he had noticed 8 years previously. The mass was clinically suspected […]

Carcinoma ex pleomorphic adenoma of the upper lip: a case ...


Author: Krista Rombouts It has long been recognized that hepatocellular carcinoma heterogeneity arises from variation in the microenvironment or from genomic alteration. Only recently it has become clear that non-genetic alterations, such as cytoskeletal rearrangement, protein localization and formation of protein complexes, are also involved in generating phenotype variability. These […]

The fibrotic microenvironment as a heterogeneity facet of hepatocellular carcinoma



Author: Yoshikuni Inokawa Background: To detect genes correlated with hepatocellular carcinoma (HCC), we developed a triple combination array consisting of methylation array, gene expression array and single nucleotide polymorphism (SNP) array analysis. Methods: A surgical specimen obtained from a 68-year-old female HCC patient was analyzed by triple combination array, which […]

Detection of doublecortin domain-containing 2 (DCDC2), a new candidate tumor ...


Author: Marcello Mancini Background: To evaluate whether Contrast Enhanced Ultrasund (CEUS) with microbubbles (MBs) targeted to VEGFR-2 is able to characterize in vivo the VEGFR-2 expression in the tumor vasculature of a mouse model of thyroid cancer (Tg-TRK-T1). Methods: Animal protocol was approved by Institutional committee on Laboratory Animal Care. […]

Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular ...