Anemia


Author: Lixian Chang Background: Fanconi anemia (FA) is a rare inherited genetic syndrome with highly variable clinical manifestations. Fifteen genetic subtypes of FA have been identified. Traditional complementation tests for grouping studies have been used generally in FA patients and in stepwise methods to identify the FA type, which can […]

Whole exome sequencing reveals concomitant mutations of multiple FA genes ...


Author: Tetsuji Terazawa Background: In Japan, transarterial infusion chemotherapy using cisplatin (CDDP-TAI) is frequently used for advanced hepatocellular carcinoma (HCC). Moreover, oral chemotherapy with S-1, an oral fluoropyrimidine derivative, has also elicited promising responses in HCC patients. We determined the recommended dosage for CDDP-TAI plus S-1 combination therapy for advanced […]

Transarterial infusion chemotherapy with cisplatin plus S-1 for hepatocellular carcinoma ...



Author: Emanuele Felli Right colon cancer rarely presents as an emergency, in which bowel occlusion and massive bleeding are the most common clinical presentations. Although there are no definite guidelines, the first line treatment for massive right colon cancer bleeding should ideally stop the bleeding using endoscopy or interventional radiology, […]

Robotic right colectomy for hemorrhagic right colon cancer: a case ...


Author: Thomas Brick Severe anemia contributes significantly to child mortality in sub-Saharan Africa. Blood transfusion is used in emergencies but carries risks. In BMC Medicine, Olupot-Olupot and colleagues report the findings of a phase II trial in children with severe anemia in Eastern Uganda. They provide important early safety and […]

Risks and benefits of transfusion for children with severe anemia ...



Author: Peter Olupot-Olupot Background: Severe anemia (SA, hemoglobin <6 g/dl) is a leading cause of pediatric hospital admission in Africa, with significant in-hospital mortality. The underlying etiology is often infectious, but specific pathogens are rarely identified. Guidelines developed to encourage rational blood use recommend a standard volume of whole blood […]

Phase II trial of standard versus increased transfusion volume in ...


Author: Flávia P Junqueira Background: Patients with Sickle cell disease (SCD) who receive regular transfusions are at risk for developing cardiac toxicity from iron overload. The aim of this study was to assess right and left cardiac volumes and function, late gadolinium enhancement (LGE) and iron deposits in patients with […]

Right and left ventricular function and myocardial scarring in adult ...



Author: Patrizia Vici Background: Currently, no clearly superior management strategy exists for recurrent, platinum-resistant ovarian cancer. We tested the efficacy and safety of gemcitabine combined with oxaliplatin (GEMOX) in a multicentre phase II clinical trial. Methods: Forty one patients with recurrent, platinum-resistant ovarian cancer were enrolled. Prior to study entry, […]

Gemcitabine-oxaliplatin (GEMOX) as salvage treatment in pretreated epithelial ovarian cancer ...


Author: Mitrakrishnan C Shivanthan Background: Congenital hemangiomas are benign abnormal proliferation of blood vessels. Noninvoluting congenital hemangiomas are a rare variant which persist, and may become bigger. Hemangiomas are known to be associated with thrombocytopenia, microangiopathic hemolytic anemia and Kasabach-Merritt phenomenon. Kasabach-Merritt phenomenon is characterized by consumptive coagulopathy with microangiopathic […]

Baseline thrombocytopenia complicated by recurrent episodes of transient severe thrombocytopenia ...



Author: Leilei Pei Background: There are multiple adverse effects of anemia on human function, particularly on women. However, few researches are conducted on women anemia in rural Western China. This study mainly aims to investigate the levels and associated factors of maternal anemia between 2001 and 2005 in this region. […]

Assessment of maternal anemia in rural Western China between 2001 ...


Author: Carlos E Coimbra Background: Although case studies indicate that indigenous peoples in Brazil often suffer from higher morbidity and mortality rates than the national population, they were not included systematically in any previous national health survey. Reported here for the first time, the First National Survey of Indigenous People’s […]

The First National Survey of Indigenous People's Health and Nutrition ...



Author: Michal Brichacek Background: Animal bites are typically harmless, but in rare cases infections introduced by such bites can be fatal. Capnocytophaga canimorsus, found in the normal oral flora of dogs, has the potential to cause conditions ranging from minor cellulitis to fatal sepsis. The tendency of C. canimorsus infections […]

Capnocytophaga canimorsus infection presenting with complete splenic infarction and thrombotic ...


Author: Martina Mayr Background: Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects. Methods: This phase I study evaluated dose limiting toxicity (DLT) of imatinib combinated with […]

Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine ...