Acute Respiratory Distress Syndrome


Author: Paul Blankman IntroductionThis study compares different parameters derived from electrical impedance tomography (EIT) data to define ‘best’ positive end-expiratory pressure (PEEP) during a decremental PEEP trial in mechanically-ventilated patients. ‘Best’ PEEP is regarded as minimal lung collapse and overdistention in order to prevent ventilator-induced lung injury. Methods: A decremental […]

Detection of 'best' positive end-expiratory pressure derived from electrical impedance ...


Author: Seitaro Fujishima Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries, and is not derived from hydrostatic pulmonary edema. One specific pathological finding of ARDS is diffuse alveolar damage. In 2012, in an […]

Pathophysiology and biomarkers of acute respiratory distress syndrome



Author: Lieuwe DJ Bos Background: The acute respiratory distress syndrome (ARDS) is a common, devastating complication of critical illness that is characterized by pulmonary injury and inflammation. The clinical diagnosis may be improved by means of objective biological markers. Electronic nose (eNose) technology can rapidly and non-invasively provide breath prints, […]

Exhaled breath profiling for diagnosing acute respiratory distress syndrome


Author: David R Janz The acute respiratory distress syndrome commonly accompanies critical illness and is associated with significant morbidity and mortality. The implementation of life saving therapies is dependent on accurately identifying patients with this syndrome; however, beyond clinical definitions, we lack ancillary tests aimed at this specific diagnosis. This […]

The needle in the haystack: searching for biomarkers in acute ...



Author: Alice G Vassiliou IntroductionGene expression profiling was performed via DNA microarrays in leukocytes from critically-ill trauma, non septic upon admission to the intensive care unit (ICU) patients, who subsequently developed either sepsis (n = 2) or severe sepsis and acute respiratory distress syndrome (ARDS; n = 3). By comparing […]

Induced expression and functional effects of Aquaporin-1 in human leukocytes ...


Author: Carlos Alves Background: Severe malaria may be complicated by the acute respiratory distress syndrome (ARDS), which is associated with a high mortality. In the present report, a series of three cases of imported malaria complicated by refractory severe ARDS supported with extracorporeal membrane oxygenation (ECMO) is presented. Methods: One […]

Extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome in ...



Author: Paolo Pelosi The occurrence of moderate to severe acute respiratory distress syndrome due to traumatic brain injury is not uncommon and is associated with an extremely high incidence of morbidity and mortality. Owing to the complex interaction between the lung and brain, protective ventilation for the lung with lower […]

High-frequency oscillatory ventilation with tracheal gas insufflation: the rescue strategy ...


Author: Sotirios Spiliopoulos We report the case of a 55 years old caucasian male patient with cardiogenic shock due to an extended myocardial infarction who underwent SynCardia Total Artificial Heart implantation and veno-venous extracorporeal membrane oxygenation with a bicaval dual-lumen cannula for the treatment of adult respiratory distress syndrome. Original […]

Veno-venous extracorporeal membrane oxygenation with a bicaval dual-lumen catheter in ...



Author: Erwin J van Drunen IntroductionModel-based methods can be used to characterise patient-specific condition and response to mechanical ventilation (MV) during treatment for acute respiratory distress syndrome (ARDS). Conventional metrics of respiratory mechanics are based on inspiration only, neglecting data from the expiration cycle. However, it is hypothesised that expiratory […]

Expiratory model-based method to monitor ARDS disease state


Author: Chih-Hao Chang Background: This retrospective study evaluated the utility and safety of surgical lung biopsy (SLB) in cancer patients with acute respiratory distress syndrome (ARDS). Methods: All cases of critically ill patients with cancer and diagnosed with ARDS who underwent SLB in a tertiary care hospital from January 2002 […]

The utility of surgical lung biopsy in cancer patients with ...



Author: Yan-Yang Wang Acute lung injury (ALI), and its more severe form, acute respiratory distress syndrome (ARDS), are syndromes of acute hypoxemic respiratory failure resulting from a variety of direct and indirect injuries to the gas exchange parenchyma of the lungs. Current treatment of ALI/ARDS is primarily supportive, with lung […]

Therapeutic implications of mesenchymal stem cells in acute lung injury/acute ...


Author: Ewan C Goligher High-frequency oscillatory ventilation (HFOV) seems ideal for lung protection in acute respiratory distress syndrome, but randomized trials have not shown a mortality reduction. The initial oxygenation response to HFOV appears to be associated with survival. Here, we discuss the mechanisms of oxygenation response to increases in […]

Re-evaluating high-frequency oscillation for ARDS: Would a targeted approach be ...



Author: Paul H Mayo In the previous issue of Critical Care, Raimondi and colleagues investigate whether lung ultrasonography has utility for the assessment of respiratory distress in the neonate. This commentary reviews the results and implications of their study. Original story

An interesting application of lung ultrasonography


Author: Stephanie L Go You are the attending intensivist in a neurointensive care unit caring for a woman five days post-rupture of a cerebral aneurysm (World Federation of Neurological Surgeons Grade 4 and Fisher Grade 3). She is intubated for airway protection and mild hypoxemia related to an aspiration event […]

Pro/con debate: Should PaCO2 be tightly controlled in all patients ...



Author: Azriel Perel The recent Berlin definition has made some improvements in the older definition of acute respiratory distress syndrome (ARDS), although the concepts and components of the definition remained largely unchanged. In an effort to improve both predictive and face validity, the Berlin panel has examined a number of […]

Extravascular lung water and the pulmonary vascular permeability index may ...