Rheumatoid Arthritis


Author: Robert P Baughman While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with […]

Goldilocks, vitamin D and sarcoidosis


Author: Periklis Panagopoulos IntroductionLeptospirosis is a zoonosis caused by the spirochete, Leptospira interrogans. While most cases of leptospirosis are mild to moderate, the course may be complicated by multiorgan dysfunction. We present a rare case of leptospirosis with acute myocarditis, pancreatitis, polyarthritis, mononeuritis multiplex and severe vasculitis with necrosis of […]

Myocarditis, pancreatitis, polyarthritis, mononeuritis multiplex and vasculitis with symmetrical peripheral ...



Author: Kavish J Bhansing IntroductionThe objective was to characterize the clinical and myopathological features of patients with scleroderma-polymyositis (SSc-PM) overlap compared to a population of patients with systemic sclerosis (SSc) and polymyositis (PM). Methods: A three-way comparison of patients with SSc-PM overlap (n = 25) with patients with SSc (n […]

Scleroderma-polymyositis overlap syndrome versus idiopathic polymyositis and systemic sclerosis: a ...


Author: Jingbo Niu Background: To examine if different rates of total knee replacement (TKR) in two similar cohorts with symptomatic knee osteoarthritis (OA) were associated with different functional impact of disease. Methods: Subjects from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI), persons with or at high risk […]

Comparing the functional impact of knee replacements in two cohorts



Author: Heming Liu Background: Although Charcot arthropathy, also known as neuropathic arthropathy, of which early diagnosis and treatment is extremely difficult, associated with other cause factor has been widely described, Charcot arthropathy caused by syringomyelia and Chiari malformation complicated with scoliosis has never been described in the literature.Case presentationA 44-year-old […]

A case report of Charcot arthropathy caused by syringomyelia and ...


Author: Yannick Degboé IntroductionOur objective was to assess the capacity of dendrimer aza-bis-phosphonate (ABP) to modulate phenotype of monocytes (Mo) and monocytes derived dendritic cells (MoDC) activated in response to TLR4 and interferon gamma (IFNgamma) stimulation. Methods: Mo (n = 12) and MoDC (n = 11) from peripheral blood of […]

Modulation of pro-inflammatory activation of monocytes and dendritic cells by ...



Author: Bradley J Rabquer Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by synovial membrane hyperplasia, inflammation, and angiogenesis. Hepatocyte growth factor (HGF) and its receptor, c-Met, are both overexpressed in the RA synovium. NK4 is an antagonist of HGF which has been shown to inhibit tumor growth, metastasis, […]

NK4 therapy: a new approach to target angiogenesis and inflammation ...


Author: Alexander So Most research in gout has concentrated on the proinflammatory mechanisms to explain the inflammation that is generated when leucocytes are in contact with monosodium urate crystals. However, the episodic nature of gout and the absence of inflammation even when crystals are present suggest that there are natural […]

How to regulate neutrophils in gout



Author: Cecilia P Chung IntroductionIn cross-sectional studies, patients with rheumatoid arthritis (RA) have higher coronary artery calcium (CAC) than controls. However, their rate of progression of CAC and the predictors of CAC progression have heretofore remained unknown. Methods: Incidence and progression of CAC were compared in 155 patients with RA […]

Progression of coronary artery atherosclerosis in rheumatoid arthritis: comparison with ...


Author: Shintaro Hirata IntroductionEvidences of biologics-free disease control after discontinuing adalimumab (ADA) in rheumatoid arthritis (RA) patients in clinical practice have not been sufficiently investigated. Purpose of this study is to investigate whether disease activity score 28 (DAS28)- erythrocyte sedimentation rate (ESR) remission was preserved after discontinuation of ADA in […]

Discontinuation of adalimumab after attaining disease activity score 28-erythrocyte sedimentation ...



Author: Chun-Kai Chiu Background: To investigate adherence and patient-specific factors associated with poor compliance with osteoporosis regimens among men. Methods: In this retrospective chart review study, we collected data on male patients with osteoporosis treated in accordance with therapeutic recommendations. Adherence was determined by the compliance and persistence of those […]

Adherence to osteoporosis regimens among men and analysis of risk ...


Author: Patrick H Dessein IntroductionWhether adiponectin levels associate with atherogenesis in RA is uncertain. We examined the independent relationships of total and high molecular weight (HMW) adiponectin concentrations with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with RA. Methods: We determined total and […]

Independent associations of total and high molecular weight adiponectin with ...



Author: Labib Ataur Rahman Background: Previous reviews of the diagnostic performances of physical tests of the hip in orthopedics have drawn limited conclusions because of the low to moderate quality of primary studies published in the literature. This systematic review aims to build on these reviews by assessing a broad […]

A systematic review of the diagnostic performance of orthopedic physical ...


Author: Mandy J Peffers IntroductionAge is an important factor in the development of osteoarthritis. Microarray studies provide insight into cartilage ageing but do not reveal the full transcriptomic phenotype of chondrocytes such as small non-coding RNAs, pseudogenes, and microRNAs. RNA-Seq is a powerful technique for the interrogation of large numbers […]

Transcriptomic signatures in cartilage ageing



Author: Suzanne Arends IntroductionThe aim of this study was to investigate the construct validity and test-retest reliability of the International Physical Activity Questionnaire (IPAQ; long form) and the Short QUestionnaire to Assess Health-enhancing physical activity (SQUASH) and to investigate the relation between daily physical activity and clinical assessments in patients […]

Daily physical activity in ankylosing spondylitis: validity and reliability of ...


Author: Ambreen Gul Muazzam IntroductionRheumatoid arthritis is an autoimmune disease with poorly understood pathophysiology. Genetic components of disease etiology, especially HLA associations, are well known. Ethnic differences account for a number of variations in disease association with HLA locus and there seem to be differences in various studies regarding its […]

Association of HLA-DRB1 and -DQB1alleles and haplotypes with rheumatoid arthritis ...



Author: Jean-Jacques Malemba IntroductionThe aim of this study was to describe the phenotype and genotype of rheumatoid arthritis (RA) in Congolese patients. Methods: All consecutive RA patients attending Kinshasa University Hospital in a three year time period were included. Demographics, clinical features and tobacco consumption were noted. Disease activity score […]

The phenotype and genotype of rheumatoid arthritis in the Democratic ...


Author: Pazit Levinger Background: Dynamic joint loading, particularly the external knee adduction moment (KAM), is an important surrogate measure for the medio-lateral distribution of force across the knee joint in people with knee osteoarthritis (OA). Foot motion may alter the load on the medial tibiofemoral joint and hence affect the […]

Relationship between foot function and medial knee joint loading in ...



Author: Saik Urien Background: Anakinra pharmacokinetics and pharmacodynamics were investigated in children and adolescents treated for systemic-onset juvenile idiopathic arthritis (SJIA) and autoinflammatory syndromes. Methods: Anakinra was given subcutaneously at doses between 2 and 10 mg/kg (maximum 100 mg) per day. Anakinra concentrations were recorded in patients, as well as […]

Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic ...


Author: Seung Bin Cha Background: Brucella abortus is an intracellular zoonotic pathogen which causes undulant fever, endocarditis, arthritis and osteomyelitis in human and abortion and infertility in cattle. This bacterium is able to invade and replicate in host macrophage instead of getting removed by this defense mechanism. Therefore, understanding the […]

Early transcriptional responses of internalization defective Brucella abortus mutants in ...



Author: Chang Dong Han Background: This study was designed to investigate the correlations of knee osteoarthritis (OA) with metabolic syndrome (MetS) and MetS parameters in Korean subjects. Methods: This study included data from 270 subjects with knee OA and 1964 control subjects with a mean age of 54.56 (SD 11.53) […]

Correlation between metabolic syndrome and knee osteoarthritis: data from the ...


Author: Takeshi Kuroda Background: We previously reported that the amount of amyloid A (AA) amyloid deposited in renal biopsy specimens was highly correlated with parameters of renal function. However, the distribution of amyloid deposits throughout the kidneys of these patients, and the degree of renal abnormality, remained unclear. Therefore, we […]

Distribution of amyloid deposits in the kidneys of a patient ...



Author: Laura E Chess Background: The purpose of this study was to assess the quality of methodology in orthopaedics-related randomized controlled trials (RCTs) published from January 2006 to December 2010 in the top orthopaedic journals based on impact scores from the Thompson ISI citation reports (2010). Methods: Journals included American […]

Risk of bias of randomized controlled trials published in orthopaedic ...


Author: David Pretzel IntroductionCurrent therapies for articular cartilage defects fail to achieve qualitatively sufficient tissue regeneration, possibly because of a mismatch between the speed of cartilage rebuilding and the resorption of degradable implant polymers. The present study focused on the self-healing capacity of resident cartilage cells in conjunction with cell-free […]

A novel in vitro bovine cartilage punch model for assessing ...