Asthma


Author: Mattia CF Prosperi Background: There is increasing recognition that asthma and eczema are heterogeneous diseases. We investigated the predictive ability of a spectrum of machine learning methods to disambiguate clinical sub-groups of asthma, wheeze and eczema, using a large heterogeneous set of attributes in an unselected population. The aim […]

Predicting phenotypes of asthma and eczema with machine learning


Author: Monica Lakhanpaul Background: South Asian children with asthma are less likely to receive prescriptions, more likely to suffer uncontrolled symptoms and acute asthma admissions compared with White British children. Understanding barriers are therefore vital in addressing health inequalities. We undertook a systematic review identifying explanatory factors for barriers and […]

A systematic review of explanatory factors of barriers and facilitators ...



Author: Michael Schuler Backround: To examine whether lack of measurement invariance (MI) influences mean comparisons among different disease groups, this paper provides (1) a systematic review of MI in generic constructs across chronic conditions and (2) an empirical analysis of MI in the Health Education Impact Questionnaire (heiQTM). Methods: (1) […]

Measurement invariance across chronic conditions: a systematic review and an ...


Author: Teeradache Viangteeravat Asthma is a prevalent disease in pediatric patients and most of the cases begin at very early years of life in children. Early identification of patients at high risk of developing the disease can alert us to provide them the best treatment to manage asthma symptoms. Often […]

Potential identification of pediatric asthma patients within pediatric research database ...



Author: Karin D Petersen Background: One fourth of the adult population in Europe suffer from respiratory allergy. Subcutaneous-allergen-specific-immunotherapy (SCIT) has long-term disease modifying effect on disease specific Health-Related Quality of Life (HRQoL). The purpose of this study was to assess the effect of SCIT on alternative disease outcomes in patients […]

Patient related outcomes in a real life prospective follow up ...


Author: Limin Zhao Background: Over-proliferation of airway smooth muscle cell (ASMC) is one of the important contributors to airway remodeling in asthma. The aim of this study was to investigate the effect of Shenmai injection (SMI) on the proliferation of the rat ASMC in asthma. Methods: Rats were randomly divided […]

The effect of Shenmai injection on the proliferation of Rat ...



Author: Kentaro Mizuta Background: Dopamine signaling is mediated by Gs protein-coupled "D1-like" receptors (D1 and D5) and Gi-coupled "D2-like" receptors (D2-4). In asthmatic patients, inhaled dopamine induces bronchodilation. Although the Gi-coupled dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle (ASM) cells, the Gs-coupled dopamine […]

The dopamine D1 receptor is expressed and facilitates relaxation in ...


Author: Magdalena H Hudy Background: Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoking is the leading risk factor for the development of COPD and 25% of asthmatics smoke. Smoking asthmatics have worse symptoms and more frequent hospitalizations compared to non-smoking asthmatics. The degree […]

Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA ...



Author: Shakil Farid Background: Surgery for pulmonary aspergillosis is infrequent and often challenging. Risk assessment is imprecise and new antifungals may ameliorate some surgical risks. We evaluated the medical and surgical management of these patients, including perioperative and postoperative antifungal therapy. Methods: Retrospective study of patients who underwent surgery for […]

Results of surgery for chronic pulmonary Aspergillosis, optimal antifungal therapy ...


Author: Carlos J Berganza The noble gas helium has many applications owing to its distinct physical and chemical characteristics, namely: its low density, low solubility, and high thermal conductivity. Chiefly, the abundance of studies in medicine relating to helium are concentrated in its possibility of being used as an adjunct […]

The role of helium gas in medicine



Author: Jinhong Wu Background: Airway inflammation is mainly mediated by T helper 2 cells (Th2) that characteristically produce interleukin (IL)-4, IL-5, and IL-13. Epidemiological studies have revealed an inverse association between the dietary intake of vitamin A and the occurrence of asthma. Serum vitamin A concentrations are significantly lower in […]

All-trans retinoic acid attenuates airway inflammation by inhibiting Th2 and ...


Author: Sonali Bose Background: The inner-city pediatric population in the United States has a disproportionate burden of asthma. Recent attention has focused on the immunomodulatory role of vitamin D, which may be protective against disease morbidity. As the primary determinant of vitamin D status in humans is exposure to sunlight, […]

Outdoor exposure and vitamin D levels in urban children with ...



Author: ¿nsu Y¿lmaz Background: Pregnant women with asthma are recommended to maintain optimal therapeutic management during pregnancy. Uncontrolled, symptomatic asthma may increase the risk of adverse peri-natal outcomes; thus adequate regular anti-asthmatic treatment must be given to provide optimal asthma control during pregnancy. However, doubts about the safety of asthmatic […]

Does drug compliance change in asthmatic patients during pregnancy?


Author: Dharshika Lakmali Amarasiri Background: Gastro-esophageal reflux disease (GERD) predisposes to airway disease through a vagally-mediated esophago-bronchial reflex. This study investigates this vagal response to esophageal acid perfusion. Methods: 40 asthmatics with mild stable asthma participated. Each subject underwent spirometry and autonomic function testing (valsalva maneuver, heart rate response to […]

Response of the airways and autonomic nervous system to acid ...



Author: Marit Helen Ebbesen Background: To determine incidence and remission of UI as well as changes in UI prevalence in the Norwegian EPINCONT surveys. Methods: The EPINCONT surveys were conducted in the county of Nord-Tr[latin small letter o with stroke]ndelag, Norway, as part of two large cross-sectional health surveys (HUNT2 […]

Prevalence, incidence and remission of urinary incontinence in women: longitudinal ...


Author: Marina Blanco-Aparicio Background: There is some evidence that quality of life measured by long disease-specific questionnaires may predict exacerbations in asthma and COPD, however brief quality of life tools, such as the Airways Questionnaire 20 (AQ20) or the Clinical COPD Questionnaire (CCQ), have not yet been evaluated as predictors […]

Utility of brief questionnaires of health-related quality of life (Airways ...



Author: Christian Kvikne Dotterud Background: Environmental factors such as tobacco exposure, indoor climate and diet are known to be involved in the development of allergy related diseases. The aim was to determine the impact of altered exposure to these factors during pregnancy and infancy on the incidence of allergy related […]

The impact of pre- and postnatal exposures on allergy related ...


Author: Hugo Cornelis van Woerden Background: There is emerging evidence for the presence of an extensive microbiota in human lungs. It is not known whether variations in the prevalence of species of microbiota in the lungs may have aetiological significance in respiratory conditions such as asthma. The aim of the […]

Differences in fungi present in induced sputum samples from asthma ...



Author: Frances M Leslie A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of in utero nicotine exposure, Rehan et al. have now demonstrated multigenerational effects of nicotine that could explain this […]

Multigenerational epigenetic effects of nicotine on lung function


Author: Camila Alexandrina Figueiredo In this work we explore differences in blood cells and cytokine profiles in children according to atopic status and asthma (atopic or non-atopic). The study involved measurement of Th1(IFN-gamma) and Th2 (IL-5 and IL-13) cytokines in Dermatophagoides pteronyssinus stimulated peripheral blood leukocytes, blood cell count, skin […]

Does IFN-gamma play a role on the pathogenesis of non-atopic ...



The impact of multiple chronic diseases on ambulatory care use; a population based study in Ontario, Canada Author: Elizabeth Muggah Background: The prevalence of multiple chronic diseases is increasing and is a common problem for primary health care providers. This study sought to determine the patient and health system burden […]

The impact of multiple chronic diseases on ambulatory care use; ...