Atrial Fibrillation


Author: Sebastian Fröhler Background: Long-QT syndrome (LQTS) causes a prolongation of the QT-interval in the ECG leading to life threatening tachyarrhythmia and ventricular fibrillation. One atypical form of LQTS, Timothy syndrome (TS), is associated with syndactyly, immune deficiency, cognitive and neurological abnormalities as well as distinct cranio-facial abnormalities.Case presentationOn a […]

Exome sequencing helped the fine diagnosis of two siblings afflicted ...


Author: Qiang Ji Background: Recent studies have demonstrated that atrial electrical remodeling was an important contributing factor for the occurrence, persistence and maintenance of atrial fibrillation. The expression changes of ionic channels, especially L-type calcium channel and potassium channel Kv4.3, were the important molecular mechanism of atrial electrical remodeling. This […]

Expression changes of ionic channels in early phase of cultured ...



Author: Raluca Mihaescu Background: It is often assumed that rare genetic variants will improve available risk prediction scores. We aimed to estimate the added predictive ability of rare variants for risk prediction of common diseases in hypothetical scenarios. Methods: In simulated data, we constructed risk models with an area under […]

Incremental value of rare genetic variants for the prediction of ...


Author: Johan Engdahl Background: In a screening study for silent atrial fibrillation (AF), which is a frequent source of cardiac emboli with ischemic stroke, the proportion of non-participants was considerable and their clinical profile differed from the participants’ profile. We intended to geo-map the target population and non-participation in an […]

Uptake of atrial fibrillation screening aiming at stroke prevention: geo-mapping ...



Author: Knut Tore Lappegård Background: Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- and microinfarctions and cognitive decline, even in the presence of adequate oral anticoagulation. AF is strongly related to increased inflammatory activity whereby anti-inflammatory agents can reduce the risk of new […]

Improved neurocognitive functions correlate with reduced inflammatory burden in atrial ...


Author: Ingrid Meex IntroductionCurrent monitoring during cardiopulmonary resuscitation (CPR) is limited to clinical observation of consciousness, breathing pattern and presence of a pulse. At the same time, the adequacy of cerebral oxygenation during CPR is critical for neurological outcome and thus survival. Cerebral oximetry, based on near-infrared spectroscopy (NIRS), provides […]

Feasibility of absolute cerebral tissue oxygen saturation during cardiopulmonary resuscitation



Author: Jelena Kornej Background: This pilot study investigated the association between heat shock protein 70 (HSP70) and anti-HSP70 antibodies as well as their changes and rhythm outcome after atrial fibrillation (AF) catheter ablation. Methods: We studied 67 patients with AF (59+/-11 years, 66 % male, 66 % lone AF) undergoing […]

Response of circulating heat shock protein 70 and anti-heat shock ...


Author: Kristoffer M Henningsen Background: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.FindingsWe included 178 young patients with lone AF and the first episode before […]

A polymorphism associated with increased levels of YKL-40 and the ...