Bipolar Disorder


Author: Ole Grønli Background: Previous studies have found an association between psychiatric disorders and vitamin D deficiency, but most studies have focused on depression. This study aimed to establish the prevalence of vitamin D deficiency in elderly patients with a wider range of psychiatric diagnoses.MethodThe study included elderly patients (>64 […]

Vitamin D deficiency is common in psychogeriatric patients, independent of ...


Author: Jeffrey DC Irvine Background: Diogenes syndrome is a behavioural disorder characterized by domestic squalor, extreme self-neglect, hoarding, and lack of shame regarding one’s living condition. Patients may present due to a range of reasons. Recognizing these will allow for earlier management of this high-mortality condition.Case presentation61-year Caucasian female known […]

Recognizing Diogenes syndrome: a case report



Author: Michael Berk Background: We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to neuroprogression in the disorder. […]

So depression is an inflammatory disease, but where does the ...


Author: Charles B Nemeroff The recent release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by the American Psychiatric Association has led to much debate. For this forum article, we asked BMC Medicine Editorial Board members who are experts in the field of psychiatry […]

DSM-5: a collection of psychiatrist views on the changes, controversies, ...



Author: Fayaz Seifuddin Background: Numerous genome-wide gene expression studies of bipolar disorder (BP) have been carried out. These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these studies to synthesize the current findings. Methods: We identified all genome-wide gene expression studies on BP in […]

Systematic review of genome-wide gene expression studies of bipolar disorder


Author: Gloria M Reeves Background: Youth with serious mental illness may experience improved psychiatric stability with second generation antipsychotic (SGA) medication treatment, but unfortunately may also experience unhealthy weight gain adverse events. Research on weight loss strategies for youth who require ongoing antipsychotic treatment is quite limited. The purpose of […]

Improving metabolic parameters of antipsychotic child treatment (IMPACT) study: rationale, ...



Author: Natsumi Ageta-Ishihara Background: In autosomal recessive early-onset Parkinsonism (PARK2), the pathogenetic process from the loss of function of a ubiquitin ligase parkin to the death of dopamine neurons remains unclear. A dominant hypothesis attributes the neurotoxicity to accumulated substrates that are exempt from parkin-mediated degradation. Parkin substrates include two […]

Chronic overload of SEPT4, a parkin substrate that aggregates in ...


Author: Hervé Maurin Background: GSK3beta is involved in a wide range of physiological functions, and is presumed to act in the pathogenesis of neurological diseases, from bipolar disorder to Alzheimer’s disease (AD). In contrast, the GSK3alpha isozyme remained largely ignored with respect to both aspects. Results: We generated and characterized […]

Neurological characterization of mice deficient in GSK3alpha highlight pleiotropic physiological ...



Author: Hideaki Katagiri Background: The efficacy and safety of olanzapine monotherapy are evaluated in Japanese patients from a large, global study of bipolar depression. Methods: This is an analysis of Japanese patients from a 6-week, global (Japan, China, Korea, Taiwan, and the United States) randomized, double-blind, placebo-controlled, Phase 3 study […]

Efficacy and safety of olanzapine for treatment of patients with ...


High-density surface EMG maps from upper-arm and forearm muscles Author: Monica Rojas-Martínez Background: sEMG signal has been widely used in different applications in kinesiology and rehabilitation as well as in the control of human-machine interfaces. In general, the signals are recorded with bipolar electrodes located in different muscles. However, such […]

High-density surface EMG maps from upper-arm and forearm muscles