Breast Cancer


Author: Thuc T Le Background: Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease. Prevention of tamoxifen-induced fatty liver has the potential to improve […]

Uridine prevents tamoxifen-induced liver lipid droplet accumulation


Author: Agnieszka K Witkiewicz A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant aspects of breast cancer biology, spanning early stage lesions to targeted treatment of metastatic disease. In ductal carcinoma in situ, multiple groups have shown […]

Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, ...



Author: Hao Zhang Background: We investigated the expression status of AGBL2 and its inhibitor latexin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. Methods: CD44+/CD24- tumor cells (CSC) from clinical specimens were sorted using flow cytometry. AGBL2 expression status […]

Clinical implications of AGBL2 expression and its inhibitor latexin in ...


Author: Mariama El Baroudi Background: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. Methods: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel […]

Pathway landscapes and epigenetic regulation in breast cancer and melanoma ...



Author: Marja Moerkens Background: Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER) alpha -positive breast cancer patients. Although the mechanisms behind tamoxifen resistance are still not completely understood, clinical data suggests that increased expression of receptor tyrosine kinases is involved. Here, we studied the estrogen […]

Epidermal growth factor receptor signalling in human breast cancer cells ...


Author: Sylvie Bérubé IntroductionIn women with breast cancer who smoke, it is unclear whether smoking could impair their survival from the disease. Methods: We examined the relation of smoking at diagnosis to breast cancer-specific and overall survival among 5,892 women with invasive breast cancer treated in one Canadian center (1987 […]

Smoking at time of diagnosis and breast cancer-specific survival: new ...



Author: Aishah Coyte Background: There is evidence that cancer survivors are at increased risk of second primary cancers. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks. Methods: We examined the incidence of second primary cancer among adults in the West of Scotland, […]

Second primary cancer risk – the impact of applying different ...


Author: Suzanne A Eccles IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods: More than 100 internationally recognised specialist breast cancer scientists, clinicians […]

Critical research gaps and translational priorities for the successful prevention ...



Author: Rebecca A Dent IntroductionThis Phase I study evaluated the safety, tolerability and efficacy of olaparib, a potent oral PARP inhibitor, in combination with paclitaxel in patients with metastatic triple-negative breast cancer (mTNBC). Methods: Eligible patients who had received <=1 prior cytotoxic regimen for mTNBC were treated with olaparib 200 […]

Phase I trial of the oral PARP inhibitor olaparib in ...


Author: D Jerry Pregnancy induces long-lasting changes in gene expression that are associated with a reduction in breast cancer risk. Although several mechanisms have been proposed to mediate the reduction in breast cancer risk among parous women, recent studies focus attention on progenitor cells as major targets. The results suggest […]

Pregnancy offers new insights into mechanisms of breast cancer risk ...



Author: Manuel Debald Background: Breast cancer is a multifactorial disease with the highest incidence rates amongst all cancer types. Further, high levels of circulating tumour cells are a characteristic of breast cancer patients demonstrating a particular predisposition to the development of breast cancer metastatic disease. Actual diagnostic approaches are frequently […]

‘Suspect molecular signature’ in blood as the indicator of undiagnosed ...


Author: Ilona Juraskova The article by Korfage and colleagues in this issue of Breast Cancer Research highlights the importance of enabling women to make informed choices about breast cancer chemoprevention. Decision aids have the potential to improve knowledge and decision-making in this context, but they do not guarantee increased uptake […]

Decision aids for breast cancer chemoprevention



Author: Rafat A Siddiqui Background: The major obstacles to the successful use of individual nutritional compounds as preventive or therapeutic agents are their efficacy and bioavailability. One approach to overcoming this problem is to use combinations of nutrients to induce synergistic effects. The objective of this research was to investigate […]

Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin ...


Author: Kristine Raaby Jakobsen Background: Protrusions of cancer cells conferrers a vital function for cell migration and metastasis. Protein and RNA localization mechanisms have been extensively examined and shown to play pivotal roles for the functional presence of specific protein components in cancer cell protrusions. Methods: To describe genome wide […]

Direct RNA sequencing mediated identification of mRNA localized in protrusions ...



Author: Jenny G Parvani Epithelial-mesenchymal transition (EMT) programs require the expression of a variety of so-called master regulators of EMT, including members of the Snail, Zeb, and Twist transcription factor families. Teleologically, the requirement for such a diverse group of ‘master regulators’ seems evolutionarily cumbersome, and emerging evidence indicates that […]

Sox4, EMT programs, and the metastatic progression of breast cancers: ...


Author: Sahra Borges IntroductionDNA methylation-induced silencing of genes encoding tumor suppressors is common in many types of cancer, but little is known about how such epigenetic silencing can contribute to tumor metastasis. The PRKD1 gene encodes protein kinase D1 (PKD1), a serine/threonine kinase that is expressed in cells of the […]

Pharmacologic reversion of epigenetic silencing of the <it>PRKD1</it> promoter blocks ...




Author: Ashley M Laughney IntroductionNationally, 25-50% of patients undergoing lumpectomy for local management of breast cancer require a secondary excision due to the persistence of residual tumor. Intra-operative assessment of specimen margins by frozen section analysis is not widely adopted in breast conserving surgery. Here, a new approach to wide-field […]

Spectral discrimination of breast pathologies in situ using spatial frequency ...



Author: Heather A Ray Background: Breast cancer survivors who participate in physical activity (PA) are reported to experience improved health-related quality of life (HRQOL). However, the quantitative research exploring the relationship between the team-based activity of dragon boat racing and the HRQOL of breast cancer survivors is limited. Given the […]

Dragon boat racing and health-related quality of life of breast ...




Author: Richard D Baird More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and […]

Genetic heterogeneity in breast cancer: the road to personalized medicine?


Author: Priyanka Sehgal Background: Insulin like growth factor binding proteins modulate the mitogenic and pro survival effects of IGF. Elevated expression of IGFBP2 is associated with progression of tumors that include prostate, ovarian, glioma among others. Though implicated in the progression of breast cancer, the molecular mechanisms involved in IGFBP2 […]

Regulation of protumorigenic pathways by Insulin like growth factor binding ...



Author: Ting Zhang IntroductionMesenchymal stem cells (MSCs) are known to migrate to tumor tissues. This behavior of MSCs has been exploited as a tumor-targeting strategy for cell-based cancer therapy. However, the effects of MSCs on tumor growth are controversial. This study was designed to determine the effect of MSCs on […]

Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of ...


Author: Takahiro Sato Background: Prolactin (PRL) is essential for normal mammary gland development. PRL promotes mammary tumor formation in rodents and elevated serum prolactin is associated with increased risk of estrogen-receptor positive breast cancer in women. On the other hand, PRL may also exert pro-differentiation effects and act to suppress […]

Global profiling of prolactin-modulated transcripts in breast cancer in vivo