Cancer


Author: Kelong Ma Background: Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon are unclear. Methods: miR-638 and SRY-box 2 (SOX2) expression levels were detected in 36 tumor samples and their […]

Loss of miR-638 in vitro promotes cell invasion and a ...


Author: Thuc T Le Background: Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease. Prevention of tamoxifen-induced fatty liver has the potential to improve […]

Uridine prevents tamoxifen-induced liver lipid droplet accumulation



Author: Ning Wen Background: The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expression levels of FOXM1 in epithelial ovarian cancer (EOC), to identify the relationship between FOXM1 […]

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell ...


Author: Thomas Mücke Background: The evidence base to inform the decision making process in patients with early stage oral cancer and a clinical and radiological N0 neck remains insufficient to answer the question when it is safe to "watch and wait" and when to proceed with a selective neck dissection. […]

Incidence and outcome for patients with occult lymph node involvement ...



Author: Kaoru Kaseda Solitary papilloma of the lung is thought to be a rare benign epithelial tumor, and complete surgical resection is currently the standard treatment for this pathology. However, some cases of papilloma have reportedly shown malignant potential. We report two cases of solitary glandular papilloma of the peripheral […]

Solitary glandular papilloma of the peripheral lung: a report of ...


Author: Martin Sokol Background: Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies. In previous studies, the assignment of mouse genes to individual retroviral integration sites has been based on close proximity and expression patterns of […]

Novel principles of gamma-retroviral insertional transcription activation in murine leukemia ...



Author: Kangsheng Tu Background: The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation. However, the clinical significance of Fbxw7 and the mechanisms involved in the anti-cancer effect of Fbxw7 in HCC are not clear.MethodThe Fbxw7 and YAP expression […]

Fbxw7 is an independent prognostic marker and induces apoptosis and ...


Author: Mitsunori Higuchi Background: Video-assisted thoracic surgery (VATS) lobectomy is a standard treatment for lung cancer. This study retrospectively compared long-term outcomes after VATS lobectomy versus lobectomy via open thoracotomy for clinical stage IA non-small cell lung cancer (NSCLC). Methods: From July 2002 to June 2012, 160 patients were diagnosed […]

Long-term outcomes after video-assisted thoracic surgery (VATS) lobectomy versus lobectomy ...



Author: David Westergaard Background: Epidemiological studies in the recent years have investigated the relationship between dietary habits and disease risk demonstrating that diet has a direct effect on public health. Especially plant-based diets -fruits, vegetables and herbs- are known as a source of molecules with pharmacological properties for treatment of […]

Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction ...




Author: Xin Xu Background: Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still unknown. Methods: Quantitative RT-PCR was used to quantify miR-182-5p expression in RCC clinical tissues. Bisulfite […]

Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via ...


Author: Rosario M Piro Background: Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes’ interactions on which a pathway’s cellular function depends. In contrast, PathWave has been developed for the analysis of high-throughput gene expression data that explicitly […]

Network topology-based detection of differential gene regulation and regulatory switches ...



Author: Jitendra Kanodia Background: The Fibroblast Growth Factor (FGF) pathway is driving various aspects of cellular responses in both normal and malignant cells. One interesting characteristic of this pathway is the biphasic nature of the cellular response to some FGF ligands like FGF2. Specifically, it has been shown that phenotypic […]

Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic ...


Author: Mathieu Amand Background: DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, […]

DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase



Author: Stephen Q Wong Background: Clinical specimens undergoing diagnostic molecular pathology testing are fixed in formalin due to the necessity for detailed morphological assessment. However, formalin fixation can cause major issues with molecular testing, as it causes DNA damage such as fragmentation and non-reproducible sequencing artefacts after PCR amplification. In […]

Sequence artefacts in a prospective series of formalin-fixed tumours tested ...


Author: Ruijin Shao Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of anti-cancer action in the endometrium of women with polycystic ovary syndrome (PCOS) have not yet been fully elucidated. Organic […]

Direct effects of metformin in the endometrium: a hypothetical mechanism ...



Author: Hung-Hsin Lin This report presents a case of collision tumors of low-grade B-cell lymphoma and adenocarcinoma in the sigmoid colon of an 81-year-old man. All surgically resected regional mesenteric lymph nodes were found to be occupied by low-grade B-cell lymphoma, and one lymph node showed the presence of adenocarcinoma. […]

Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis ...


Author: Sudjit Luanpitpong Background: Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects are a major concern. The objective of this study was to address human lung cancer risks associated with chronic pulmonary exposure to single-walled […]

Induction of stem-like cells with malignant properties by chronic exposure ...



Author: Shinro Hata Background: Pseudoaneurysms are caused by trauma, tumors, infections, vasculitis, atherosclerosis and iatrogenic complications. In this paper, we report about a patient with rupture of an external iliac artery pseudoaneurysm, which lead to hemorrhagic shock, after undergoing laparoscopic radical cystectomy and extended pelvic lymphadenectomy.Case presentationThe patient was a […]

Life-threatening rupture of an external iliac artery pseudoaneurysm caused by ...


Author: Heyang Xu Background: Tumor-associated macrophages (TAMs) are known to promote cancer progression and metastasis through the release of a variety of cytokines. Phosphatase of regenerating liver (PRL-3) has been considered as a marker of colorectal cancer (CRC) liver metastasis. Our previous research suggests that PRL-3 can enhance the metastasis […]

Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo ...



Author: Je-Gun Joung Background: Clinical statement alone is not enough to predict the progression of disease. Instead, the gene expression profiles have been widely used to forecast clinical outcomes. Many genes related to survival have been identified, and recently miRNA expression signatures predicting patient survival have been also investigated for […]

Integrated analysis of microRNA-target interactions with clinical outcomes for cancers


Author: Agnieszka K Witkiewicz A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant aspects of breast cancer biology, spanning early stage lesions to targeted treatment of metastatic disease. In ductal carcinoma in situ, multiple groups have shown […]

Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, ...



Author: Mariama El Baroudi Background: Epigenetic variation is a main regulation mechanism of gene expression in various cancer histotypes, and due to its reversibility, the potential impact in therapy can be very relevant. Methods: Based on a selected pair, breast cancer (BC) and melanoma, we conducted inference analysis in parallel […]

Pathway landscapes and epigenetic regulation in breast cancer and melanoma ...


Author: Hao Zhang Background: We investigated the expression status of AGBL2 and its inhibitor latexin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. Methods: CD44+/CD24- tumor cells (CSC) from clinical specimens were sorted using flow cytometry. AGBL2 expression status […]

Clinical implications of AGBL2 expression and its inhibitor latexin in ...