Coagulation


Author: Xinyuan Zhang Diabetic macular edema (DME), a serious eye complication caused primarily by hyperglycemia, is one of the major causes of blindness. DME, which is characterized by cystic retinal thickening or lipid deposition, is prone to relapse after successful treatment. DME is a complex pathological process caused by multiple […]

Diabetic macular edema: new concepts in patho-physiology and treatment


Author: Emanuele Felli Right colon cancer rarely presents as an emergency, in which bowel occlusion and massive bleeding are the most common clinical presentations. Although there are no definite guidelines, the first line treatment for massive right colon cancer bleeding should ideally stop the bleeding using endoscopy or interventional radiology, […]

Robotic right colectomy for hemorrhagic right colon cancer: a case ...



Author: Louise Schilder IntroductionNeutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury (AKI) and levels reflect severity of disease in critically ill patients. However, continuous venovenous hemofiltration (CVVH) may affect plasma levels by clearance or release of NGAL by activated neutrophils in the filter, dependent on the anticoagulation […]

The plasma level and biomarker value of neutrophil gelatinase-associated lipocalin ...


Author: Keith Chiu Haemorrhage is the primary complication of anticoagulation therapy with the gastrointestinal, urinary and nasal tracts the most common sites of bleeding. Haematoma within solid organs is uncommon especially in the absence of blunt trauma. We describe two patients on long term Warfarin therapy who developed focal haematomas […]

Isolated pancreatic heamorrhage in association with anticoagulation



Author: Ross Davenport Fibrinogen is fundamental to hemostasis and falls rapidly in trauma hemorrhage, although levels are not routinely measured in the acute bleeding episode. Prompt identification of critically low levels of fibrinogen and early supplementation has the potential to correct trauma-induced coagulation and improve outcomes. Early estimation of hypofibrinogenemia […]

Fibrinogen depletion in trauma: early, easy to estimate and central ...


Author: Sarita Mohapatra Background: Disseminated intravascular coagulation (DIC) due to Plasmodium vivax is scarcely reported in comparison to Plasmodium falciparum. In complicated malaria, thrombocytopaenia and haemostatic alterations lead to increased activation of coagulation cascade and fibrinolytic system. Thromboelastography (TEG) is a haemostasis system which measures the viscoelastic strength of blood […]

Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a ...



Author: Andrea Polito IntroductionSepsis-associated brain dysfunction has been linked to white matter lesions (leucoencephalopathy) and ischemic stroke. Our objective was to assess the prevalence of brain lesions in septic shock patients requiring magnetic resonance imaging (MRI) for an acute neurological change.MethodSeventy-one septic shock patients were included in a prospective observational […]

Pattern of brain injury in the acute setting of human ...


Author: Ning Tang Background: Coagulopathy often develops in patients with serious trauma and is correlated with the clinical outcome. The contribution of platelet activity and endothelial dysfunction to trauma-induced coagulopathy remain to be defined. The purpose of this study was to investigate the time courses of soluble P-selectin (sPsel, an […]

Time course of soluble P-selectin and von Willebrand factor levels ...



Author: Marcel Levi The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adequately assess the presence of DIC but also have strong prognostic power for morbidity and mortality. In this issue of Critical […]

Another step in improving the diagnosis of disseminated intravascular coagulation ...


Author: Eduardo Tamayo Aguirre Background: The skills of patients on oral anticoagulants are critical for achieving good outcomes with this treatment. Self-management, or the capacity of patients to control their INR level and adjust their treatment, is an effective strategy of treatment. Capacity of patients to self manage is determined […]

Oral anticoagulation and self-management: analysis of the factors that determine ...



Author: Dieter Schmidt Background: Several general diseases cause blindness in patients with simultaneous combined retinal artery and vein occlusion.Methods/patients: We examined 14 patients with acute unilateral visual loss due to combined retinal artery and venous occlusions. All 14 patients presented at the Polyclinic over a period of about 3 years. […]

Comorbidities in combined retinal artery and vein occlusions


Author: Freeha Arshad Background: In patients with cirrhosis, the synthesis of coagulation factors can fall short, reflected by a prolonged prothrombin time. Although anticoagulants factors are decreased as well, blood loss during orthotopic liver transplantation can still be excessive. Blood loss during orthotopic liver transplantation is currently managed by transfusion […]

Prothrombin complex concentrate in the reduction of blood loss during ...



Author: Knut Tore Lappegård Background: Atrial fibrillation (AF) is associated with increased mortality and morbidity, including risk for cerebral macro- and microinfarctions and cognitive decline, even in the presence of adequate oral anticoagulation. AF is strongly related to increased inflammatory activity whereby anti-inflammatory agents can reduce the risk of new […]

Improved neurocognitive functions correlate with reduced inflammatory burden in atrial ...


Author: Jung-Jin Lee Background: Soshiho-tang (SH; Chinese name, Xiao-Chai-Hu-Tang; Japanese name, Shosaiko-to) is a traditional Korean, Chinese, and Japanese medicine, which has been used to treat various conditions, including hepatitis, liver cirrhosis, and chronic and acute liver disease. SH consists of seven herbal components, of which Scutellaria baicalensis Georgi and […]

Antithrombotic and antiplatelet activities of Soshiho-tang extract



Author: Patrick Rossignol Background: Anticoagulation for chronic dialysis patients with contraindications to heparin administration is challenging. Current guidelines state that in patients with increased bleeding risks, strategies that can induce systemic anticoagulation should be avoided. Heparin-free dialysis using intermittent saline flushes is widely adopted as the method of choice for […]

Rationale and design of the HepZero study: a prospective, multicenter, ...


Author: Ryo Suzuki A 58-year-old Japanese female was referred to our hospital. Although the electrocardiogram showed ST elevation, coronary angiography showed intact coronary artery. We diagnosed Takotsubo cardiomyopathy and a left ventricular thrombus. Anticoagulation was administered; however, the left ventricular thrombus had become mobile and protrusive. We extirpated the left […]

Transapical extirpation of a left ventricular thrombus in takotsubo cardiomyopathy



Author: Luis Teodoro da Luz Background: Thrombelastography is a laboratorial test that measures viscoelastic changes of the entire clotting process. There is growing interest in its clinical use in trauma resuscitation, particularly for managing acute coagulopathy of trauma and assisting decision making concerning transfusion. This review focuses on the clinical […]

Thrombelastography (TEG(R)): practical considerations on its clinical use in trauma ...


Author: Karim Asehnoune Protease-activated receptors (PARs) belong to the family of G protein-coupled receptors. Among the four members, PAR1 plays a major role in orchestrating the interactions between coagulation and inflammation. PAR1 has opposing functions during sepsis, and PAR1 blockade or activation may be alternatively beneficial at early or late […]

Protease-activated receptor-1: key player in the sepsis coagulation-inflammation crosstalk



Author: Takahiro Kato Background: Early treatment of disseminated intravascular coagulation (DIC) can be associated with improved patient outcomes. The Japanese Ministry of Health and Welfare (JMHW) and the International Society on Thrombosis and Haemostasis (ISTH) criteria are the most specific for diagnosis of septic DIC. The revised Japanese Association for […]

Recombinant human soluble thrombomodulin administration improves sepsis-induced disseminated intravascular coagulation ...


Author: Shaowei Wu Background: Ambient air pollution has been associated with activation of systemic inflammation and hypercoagulability and increased plasma homocysteine, but the chemical constituents behind the association are not well understood. We examined the relations of various chemical constituents of fine particles (PM2.5) and biomarkers of inflammation, coagulation and […]

Chemical constituents of ambient particulate air pollution and biomarkers of ...