Chronic Depression


Author: Michael Liebrenz Background: Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with high rates of comorbid substance use disorders, and cigarette smoking has a particularly high prevalence in this population. However, there is an ongoing debate as to whether this tobacco use is an attempt at "self-medication" or due to behavioral […]

Adult attention-deficit/hyperactivity disorder and nicotine use: a qualitative study of ...


Author: Maureen Markle-Reid Background: Depressive symptoms in older home care clients are common but poorly recognized and treated, resulting in adverse health outcomes, premature institutionalization, and costly use of health services. The objectives of this study were to examine the feasibility and acceptability of a new six-month interprofessional (IP) nurse-led […]

An interprofessional nurse-led mental health promotion intervention for older home ...



Author: Leona Tan Background: Depression is a major public health problem among working-age adults. The workplace is potentially an important location for interventions aimed at preventing the development of depression, but to date, the mental health impact of universal interventions in the workplace has been unclear.MethodA systematic search was conducted […]

Preventing the development of depression at work: a systematic review ...


Author: Ole Grønli Background: Previous studies have found an association between psychiatric disorders and vitamin D deficiency, but most studies have focused on depression. This study aimed to establish the prevalence of vitamin D deficiency in elderly patients with a wider range of psychiatric diagnoses.MethodThe study included elderly patients (>64 […]

Vitamin D deficiency is common in psychogeriatric patients, independent of ...



Author: Joanne Woodford Background: Increased life expectancy has resulted in a greater provision of informal care within the community for patients with chronic physical health conditions. Informal carers are at greater risk of poor mental health, with one in three informal carers of stroke survivors experiencing depression. However, currently no […]

Supported cognitive-behavioural self-help versus treatment-as-usual for depressed informal carers of ...


Author: Jingbo Niu Background: To examine if different rates of total knee replacement (TKR) in two similar cohorts with symptomatic knee osteoarthritis (OA) were associated with different functional impact of disease. Methods: Subjects from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI), persons with or at high risk […]

Comparing the functional impact of knee replacements in two cohorts



Author: Nancy A Neilan Background: An altered intestinal mucosal barrier has been demonstrated in subsets of patients with IBS and FAP and may be an additional biological factor contributing to symptom generation in children with FD. The objective of this study was to determine if intestinal permeability is increased in […]

Intestinal permeability in children/adolescents with functional dyspepsia


Author: Mengjun Wu Background: Generic preference-based measures such as the EQ-5D and SF-6D have been criticised for being narrowly focused on a sub-set of dimensions of health. Our study aims to explore whether long-standing health conditions have an incremental impact on subjective well-being alongside the EQ-5D. Methods: Using data from […]

Examining the incremental impact of long-standing health conditions on subjective ...



Author: Jeffrey A Cully Background: Depression and diabetes cause significant burden for patients and the healthcare system and, when co-occurring, result in poorer self-care behaviors and worse glycemic control than for either condition alone. However, the clinical management of these comorbid conditions is complicated by a host of patient, provider, […]

Behavioral health coaching for rural veterans with diabetes and depression: ...


Author: Matthew Hyett Background: Cognitive disturbances in depression are pernicious and so contribute strongly to the burden of the disorder. Cognitive function has been traditionally studied by challenging subjects with modality-specific psychometric tasks and analysing performance using standard analysis of variance. Whilst informative, such an approach may miss deeper perceptual […]

Bias and discriminability during emotional signal detection in melancholic depression



Author: Bulent Turan Background: Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs. Methods: Participants were 63 newly […]

The impact of depression and ghrelin on body weight in ...


Author: Barbara J Jefferis Background: Physical activity (PA) levels in older adults decline with age. The prevalence and correlates of adherence to current UK PA guidelines in older adults has not been studied using objectively measured PA, which can examine precisely whether PA is carried out in bouts of specified […]

Adherence to physical activity guidelines in older adults, using objectively ...



Author: Flavia Macchi Background: Growing evidence suggests that alterations of the inflammatory/immune system contribute to the pathogenesis of depression. Indeed, depressed patients exhibit increased levels of inflammatory markers in both the periphery and the brain, and high comorbidity exists between major depression and diseases associated with inflammatory alterations. In order […]

Altered inflammatory responsiveness in serotonin transporter mutant rats


Author: Rafat Hussain Background: University students are often perceived to have a privileged position in society and considered immune to ill-health and disability. There is growing evidence that a sizeable proportion experience poor physical health, and that the prevalence of psychological disorders is higher in university students than their community […]

Physical and mental health perspectives of first year undergraduate rural ...



Author: Michael Berk Background: We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to neuroprogression in the disorder. […]

So depression is an inflammatory disease, but where does the ...


Author: Charles B Nemeroff The recent release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by the American Psychiatric Association has led to much debate. For this forum article, we asked BMC Medicine Editorial Board members who are experts in the field of psychiatry […]

DSM-5: a collection of psychiatrist views on the changes, controversies, ...



Author: Alfredo Gea Background: Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake. Methods: We followed-up 5,505 high-risk men and women (55 […]

Alcohol intake, wine consumption and the development of depression: the ...


Author: Gabriel R Cojocaru Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular system affect both directly and indirectly the function in a variety of organs, including the brain, with consequent neurological (motor and sensory performance) and cognitive impairments, as well as leading […]

Post-stroke depression and the aging brain



Author: Nahal Mavaddat Background: Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke survivors has received little attention compared to that in other older individuals. This study identifies determinants of self-rated […]

What determines the self-rated health of older individuals with stroke ...


Author: Yi-Long Yang Background: A lot of empirical studies have been conducted to evaluate the prevalence of depression and anxiety among Chinese adults with cancer. We aimed to conduct a meta-analysis in order to evaluate the prevalence and odds ratios of depression and anxiety in Chinese adults with cancer compared […]

The prevalence of depression and anxiety among Chinese adults with ...



Author: Karina L Allen Background: Adolescence is a period of developmental risk for eating disorders and eating disorder symptoms. This study aimed to describe the prevalence and trajectory of five core eating disorder behaviours (binge eating, purging, fasting, following strict dietary rules, and hard exercise for weight control) and a […]

Eating disorder symptom trajectories in adolescence: effects of time, participant ...


Author: Raj S Padwal Background: In Canada, demand for multidisciplinary bariatric (obesity) care far outstrips capacity. Consequently, prolonged wait times exist and contribute to substantial health impairments.A supportive, educational intervention (with in-person and web-based versions) designed to enhance the self-management skills of patients wait-listed for multidisciplinary bariatric medical and surgical […]

The evaluating self-management and educational support in severely obese patients ...



Author: Marie Thi Tran Background: Multiple chemical sensitivity (MCS) is a chronic condition of unknown etiology. MCS is characterized by recurrent nonspecific symptoms from multiple organ systems in response to chemical exposures in concentrations that are normally tolerated by the majority of the population. The symptoms may have severe impact […]

Transcranial pulsed electromagnetic fields for multiple chemical sensitivity: study protocol ...


Author: Gloria M Reeves Background: Youth with serious mental illness may experience improved psychiatric stability with second generation antipsychotic (SGA) medication treatment, but unfortunately may also experience unhealthy weight gain adverse events. Research on weight loss strategies for youth who require ongoing antipsychotic treatment is quite limited. The purpose of […]

Improving metabolic parameters of antipsychotic child treatment (IMPACT) study: rationale, ...