Diabetes


Author: Bärbel Knäuper Background: The Diabetes Prevention Program (DPP) is highly effective in promoting weight loss in overweight and obese individuals. However, one-on-one DPP sessions are costly. As a cost-saving alternative, a group version of the DPP, called Group Lifestyle Balance program (GLB), has been developed but has been shown […]

Increasing the effectiveness of the Diabetes Prevention Program through if-then ...


Author: Christian Cadeddu Background: Metformin (MET) therapy exerts positive effects improving glucose tolerance and preventing the evolution toward diabetes in insulin resistant patients. It has been shown that adding MET to exercise training does not improve insulin sensitivity. The aim of this study was to determine the effect of MET […]

Effects of metformin and exercise training, alone or in association, ...



Author: Fangyuan Jing Background: The apoB/apoA1 ratio has been reported to be associated with the metabolic syndrome (MetS), and it may be a more convenient biomarker in MetS predicting. However, whether apoB/apoA1 ratio is a better indicator of metabolic syndrome than other biomarkers and what is the optimal cut-off value […]

The value of Apolipoprotein B/Apolipoprotein A1 ratio for metabolic syndrome ...


Author: Timothy M Dall Background: Screening to detect prediabetes and diabetes enables early prevention and intervention. This study describes the number and characteristics of asymptomatic, undiagnosed adults in the United States who could be detected with prediabetes and type 2 diabetes using the American Diabetes Association (ADA) guidelines compared to […]

Detecting type 2 diabetes and prediabetes among asymptomatic adults in ...



Author: Margaret G Parker Background: To evaluate the association between prepregnancy body mass index (BMI) is associated with early vs. late and medically-induced vs. spontaneous preterm birth (PTB) subtypes. Methods: Using data from the Boston Birth Cohort, we examined associations of prepregnancy BMI with 189 early (<34 completed weeks) and […]

Prepregnancy body mass index and risk of preterm birth: association ...


Author: Jeffrey A Cully Background: Depression and diabetes cause significant burden for patients and the healthcare system and, when co-occurring, result in poorer self-care behaviors and worse glycemic control than for either condition alone. However, the clinical management of these comorbid conditions is complicated by a host of patient, provider, […]

Behavioral health coaching for rural veterans with diabetes and depression: ...



Author: Sophie Liabeuf Background: Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly altered kidney function was to evaluate levels of inactive, dephospho-uncarboxylated MGP(dp-ucMGP) and total uncarboxylated MGP(t-ucMGP) and assess their links with […]

Vascular calcification in patients with type 2 diabetes: the involvement ...


Author: Thérèse Van Durme Background: Adequate care for individuals living with chronic illnesses calls for a healthcare system redesign, moving from acute, disease-centered to patient-centered models. The aim of this study was to identify Belgian stakeholders’ perceptions on the strengths, weaknesses, opportunities and threats of the healthcare system for people […]

Stakeholders' perception on the organization of chronic care: a SWOT ...



Author: Yasuko Kitagishi Traumatic encephalopathy has emerged as a significant public health problem. It is believed that traumatic encephalopathy is caused by exposure to repetitive brain trauma prior to the initial symptoms of neurodegenerative disease. Therefore, prevention is important for the disease. The PI3K/AKT/PTEN (phosphoinositide-3 kinase/AKT/phosphatase and tensin homologue deleted […]

Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to ...


Author: WA Nuwan Kumara Background: To study the prevalence and define deferential risk factors for ‘Resistant’ hypertension (RHT) in a hypertensive population of South Asian origin. Methods: A descriptive cross-sectional study was carried out among hypertensive patients attending clinics at the Cardiology Unit, Colombo from July-October 2009. All the patients […]

Prevalence and risk factors for resistant hypertension among hypertensive patients ...



Author: Yang Su Background: Increased levels of the sugar metabolite methylglyoxal (MG) in vivo were shown to participate in the pathophysiology of vascular complications in diabetes. Alterations of endothelial nitric oxide synthase (eNOS) activity by hypophosphorylation of the enzyme and enhanced monomerization are found in the diabetic milieu, and the […]

Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial ...




Author: Sudarshan Shetty The gut microbiome is a complex ecosystem that affects the development, immunological responses and nutritional status of the host. Efforts are being made to unravel the complex interaction between the gut microbiome and host to have a greater understanding about its role in human health. Colonization of […]

Opportunities and challenges for gut microbiome studies in the Indian ...


Author: Lindsay Macdonald Background: Diabetes is a major health issue for individuals and for health services. There is a considerable literature on the management of diabetes and also on communication in primary care consultations. However, few studies combine these two topics and specifically in relation to nurse communication. This paper […]

Nurse-patient communication in primary care diabetes management: an exploratory study



Author: Diangeng Li IntroductionThe apoptosis and subsequent injury of podocytes plays a pathogenic role in diabetic nephropathy (DN). Mesenchymal stem cells (MSCs) are promising therapeutic cells for preventing apoptosis and reducing cellular injury. Our previous study found MSCs could protect kidneys from diabetes-induced injury without obvious engraftment. So we evaluated […]

Mesenchymal stem cells protect podocytes from apoptosis induced by high ...


Author: Mubarakali N Janmohamed Background: The number of adults with diabetes mellitus is increasing worldwide, particularly in Asia and Africa. In sub-Saharan Africa, renal complications of diabetes may go unrecognized due to limited diagnostic resources. The prevalence of chronic kidney disease (CKD) among adult diabetics in sub-Saharan Africa has not […]

Prevalence of chronic kidney disease in diabetic adult out-patients in ...



Author: Patrice Njomnang Soh Background and purposeTo analyze erectile function in men treated by prostate brachytherapy (PB) for localized prostate cancer.Material and methodsOf a series of 270 sexually active men treated by PB, 241 (89%), mean age 65 yr (range, 43–80 yr), participated in a study on erectile function that was evaluated […]

Erectile function after permanent 125I prostate brachytherapy for localized prostate ...


Author: Odette R Gibson Background: Primary health care is recognised as an integral part of a country’s health care system. Measuring hospitalisations, that could potentially be avoided with high quality and accessible primary care, is one indicator of how well primary care services are performing. This review was interested in […]

A systematic review of evidence on the association between hospitalisation ...



Author: Nahal Mavaddat Background: Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke survivors has received little attention compared to that in other older individuals. This study identifies determinants of self-rated […]

What determines the self-rated health of older individuals with stroke ...


Author: Hyacinthe Tchewonpi Kankeu Non-communicable diseases (NCDs) were previously considered to only affect high-income countries. However, they now account for a very large burden in terms of both mortality and morbidity in low- and middle-income countries (LMICs), although little is known about the impact these diseases have on households in […]

The financial burden from non-communicable diseases in low- and middle-income ...



Author: Zahra Bahadoran In recent years, there is growing evidence that plant-foods polyphenols, due to their biological properties, may be unique nutraceuticals and supplementary treatments for various aspects of type 2 diabetes mellitus. In this article we have reviewed the potential efficacies of polyphenols, including phenolic acids, flavonoids, stilbenes, lignans […]

Dietary polyphenols as potential nutraceuticals in management of diabetes: a ...


Author: Walter de Back Background: Replacement of dysfunctional beta-cells in the islets of Langerhans by transdifferentiation of pancreatic acinar cells has been proposed as a regenerative therapy for diabetes. Adult acinar cells spontaneously revert to a multipotent state upon tissue dissociation in vitro and can be stimulated to redifferentiate into […]

Lineage conversion in the pancreas by loss of lateral signaling



Author: Lieke GM Raaijmakers Background: The need to understand barriers to the implementation of health care innovations in daily practice has been widely documented, but perceived facilitators and barriers in diabetes care by Dutch health care professionals remain unknown. The aim of this study was to investigate these factors among […]

Perceived facilitators and barriers in diabetes care: a qualitative study ...


Author: Eva Henriksen Background: Privacy and information security are important for all healthcare services, including home-based services. We have designed and implemented a prototype technology platform for providing home-based healthcare services. It supports a personal electronic health diary and enables secure and reliable communication and interaction with peers and healthcare […]

Privacy and information security risks in a technology platform for ...