Edema


Author: Hidetaka Noma Background: The association of inflammatory factors and the aqueous flare value with macular edema in branch retinal vein occlusion (BRVO) patients remains unclear. The relationship between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, […]

Role of Inflammation in Previously Untreated Macular Edema with Branch ...


Author: Xinyuan Zhang Diabetic macular edema (DME), a serious eye complication caused primarily by hyperglycemia, is one of the major causes of blindness. DME, which is characterized by cystic retinal thickening or lipid deposition, is prone to relapse after successful treatment. DME is a complex pathological process caused by multiple […]

Diabetic macular edema: new concepts in patho-physiology and treatment



Author: Christopher A Robinson Acute hemorrhagic leukoencephalitis (AHL) is a fulminant demyelinating disease of unknown etiology. Most cases are fatal within one week from onset. AHL pathology varies with the acuteness of disease. Hemorrhages, vessel fibrinoid necrosis, perivascular fibrin exudation, edema and neutrophilic inflammation are early features, while perivascular demyelination, […]

Early and widespread injury of astrocytes in the absence of ...


Author: Seitaro Fujishima Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries, and is not derived from hydrostatic pulmonary edema. One specific pathological finding of ARDS is diffuse alveolar damage. In 2012, in an […]

Pathophysiology and biomarkers of acute respiratory distress syndrome



Author: Lieuwe DJ Bos Background: The acute respiratory distress syndrome (ARDS) is a common, devastating complication of critical illness that is characterized by pulmonary injury and inflammation. The clinical diagnosis may be improved by means of objective biological markers. Electronic nose (eNose) technology can rapidly and non-invasively provide breath prints, […]

Exhaled breath profiling for diagnosing acute respiratory distress syndrome


Author: Changsheng He Backgrounds: Extracorporeal membrane oxygenation (ECMO) has been recommended for treatment of acute, potentially reversible, life-threatening respiratory failure unresponsive to conventional therapy. Intestinal mucosal barrier dysfunction is one of the most critical pathophysiological disorders during ECMO. This study aimed to determine whether combination with CRRT could alleviate damage […]

Effects of continuous renal replacement therapy on intestinal mucosal barrier ...



Author: Erik K Hartmann Background: The lectin-like domain of TNF-alpha mimicked by an inhaled TIP peptide represents a novel approach to attenuate a pulmonary edema in respiratory failure, which is on the threshold to clinical application. In extension to a previously published study, which reported an improved pulmonary function following […]

TIP peptide inhalation in oleic acid-induced experimental lung injury: a ...


Author: Pankaj Tiwari Lymphedema remains a poorly understood entity that can occur after lymphadenectomy. Herein, we will review the pathogenesis of lymphedema, diagnostic modalities and the natural history of extremity involvement. We will review the incidence of upper extremity lymphedema in patients treated for breast malignancies and lower extremity lymphedema […]

Breast and gynecologic cancer-related extremity lymphedema: a review of diagnostic ...



Author: Katsuji Sawai We report here a case of partial response to hepatic arterial infusion chemotherapy in a patient who developed serious hepatic failure due to unresectable colorectal cancer and hepatic metastasis and showed resistance to systemic chemotherapy with molecular targeted drugs, mFOLFOX6, and FOLFIRI. The patient was a 60-year-old […]

Partial response after transcatheter arterial infusion chemotherapy in a patient ...


Author: Marco Lattuada IntroductionWe hypothesized that mechanical ventilation per se increases abdominal edema and inflammation in sepsis and tested this in experimental endotoxemia. Methods: Thirty anesthetized piglets were allocated to one of five groups: healthy control pigs breathing spontaneously with continuous positive pressure of 5 cm H2O or mechanically ventilated […]

Mechanical ventilation worsens abdominal edema and inflammation in porcine endotoxemia



Author: Peter Kellman Background: Quantitative measurements in the myocardium may be used to detect both focal and diffuse disease processes that result in an elevation of T1 and/or extracellular volume (ECV) fraction. Detection of abnormal myocardial tissue by these methods is affected by both the accuracy and precision. The sensitivity […]

T1 and extracellular volume mapping in the heart: estimation of ...


Author: Natália Fernandes Background: Abrupt and life-threatening presentations in connective tissue diseases (CTD) are rarely reported. Their early recognition and specific management could change course disease. SLE is a multisystem inflammatory disease that is often difficult to diagnose in the emergency department (ED).Case presentationA 26-year-old woman presented to the ED […]

Presentation of systemic lupus erythematosus (SLE) in emergency department: a ...



Author: Antonio M Esquinas Rodriguez Non-invasive mechanical ventilation (NIV) has proved to be an excellent technique in selected critically ill patients with different forms of acute respiratory failure. However, NIV can fail on account of the severity of the disease and technical problems, particularly at the interface. The helmet could […]

Clinical review: Helmet and non-invasive mechanical ventilation in critically ill ...


Author: Azriel Perel The recent Berlin definition has made some improvements in the older definition of acute respiratory distress syndrome (ARDS), although the concepts and components of the definition remained largely unchanged. In an effort to improve both predictive and face validity, the Berlin panel has examined a number of […]

Extravascular lung water and the pulmonary vascular permeability index may ...



Author: Anelise S Formagio Background: Annona dioica St. Hill (Annonacaeae) is a Brazilian plant used in folk medicine for the treatment of several types of rheumatisms and diarrhoea. The focus of this work was to evaluate the in vitro antiproliferative and antioxidant activity and the in vivo hypoglycaemic and anti-inflammatory […]

The flavonoid content and antiproliferative, hypoglycaemic, anti-inflammatory and free radical ...


Author: Pierre Esnault Dialysis disequilibrium syndrome is a brain disease characterized by neurological symptoms due to cerebral oedema after a treatment by hemodialysis . However a direct measurement of intracranial pressure rarely objectified this oedema. We report the case of a patient having a dialysis disequilibrium syndrome diagnosed by an […]

Dialysis disequilibrium syndrome in neurointensive care unit: the benefit of ...



Author: Serena Bugatti The synovial tissue stands at the epicenter of joint pathology in rheumatoid arthritis (RA). As a primary target of the disease, studies on the synovium have provided invaluable insights into the mechanisms involved in disease pathogenesis. Recent work has however revealed the importance of a previously unseen […]

Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: ...