Endocrine System


Author: Christos G Kostopoulos Background: Depending on their anatomical location, different fat depots have a different capacity to produce bioactive peptides, called adipokines. Adipokines produced by periadventitial fat have been implicated in the pathogenesis of vascular disease, including atherosclerosis. Chemerin is an adipokine with an established role in immunity, adipose […]

Chemerin and CMKLR1 expression in human arteries and periadventitial fat: ...


Author: Suzanne A Eccles IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods: More than 100 internationally recognised specialist breast cancer scientists, clinicians […]

Critical research gaps and translational priorities for the successful prevention ...



Author: Gillian E White High-intensity exercise is associated with mechanical and/or metabolic stresses that lead to reduced performance capacity of skeletal muscle, soreness and inflammation. Cold-water immersion and other forms of cryotherapy are commonly used following a high-intensity bout of exercise to speed recovery. Cryotherapy in its various forms has […]

Cold-water immersion and other forms of cryotherapy: physiological changes potentially ...


Author: Ying Jiang Background: Kidney transplant recipients are recognized as a vulnerable population that is at increased risk of adverse health outcomes. However, there have been few studies that have compared hospital-related morbidity of these patients to the general population, and how this differs with respect to time since transplantation. […]

Long-term follow-up of kidney transplant recipients: comparison of hospitalization rates ...



Author: Trivia P Frazier Background: Obesity is associated with a higher risk of developing cancer and co-morbidities that are part of the metabolic syndrome. Adipose tissue is recognized as an endocrine organ, as it affects a number of physiological functions, and contains adipose tissue-derived stem cells (ASCs). ASCs can differentiate […]

Body mass index affects proliferation and osteogenic differentiation of human ...


Author: Stefania Bruno Accumulating evidence indicates that the protective effect of mesenchymal stem cells in models of tissue injury is related to the endocrine/pcrine release of factors. The delivery of growth factors, cytokines, prostaglandins, enzymes or extracellular vesicles from mesenchymal stem cells to target cells may induce cell reprogramming and […]

Therapeutic effects of mesenchymal stem cells on renal ischemia–reperfusion injury: ...



Author: Kexin Meng Background: Chemotherapy-induced amenorrhea (CIA) is one of the most frequent therapy-related adverse events observed in patients who have undergone chemotherapy . Although the characteristics of CIA have been studied in Western countries, little is known about CIA in Asian women, particularly those with breast cancer. We conducted […]

Impact of chemotherapy-induced amenorrhea in breast cancer patients: the evaluation ...


Author: Padmalaya Das Breast cancer is a complex and heterogeneous disease that affects about one out of every eight women. In the last decade, several advancements have been made that have increased our understanding of breast cancer and have allowed us to more accurately diagnose and treat this disease in […]

Illuminating luminal B: QSOX1 as a subtype-specific biomarker



Author: Bess A Marshall Background: Wolfram Syndrome (WFS:OMIM 222300) is an autosomal recessive, progressive, neurologic and endocrinologic degenerative disorder caused by mutations in the WFS1 gene, encoding the endoplasmic reticulum (ER) protein wolframin, thought to be involved in the regulation of ER stress. This paper reports a cross section of […]

Phenotypic characteristics of early Wolfram syndrome


Author: Juliana Giacomazzi Background: Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline mutations in the TP53 gene. In Brazil, a particular mutation, occurring in the tetramerisation domain of the gene, […]

TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from ...



Author: Debra A Bangasser Stress-related psychiatric disorders, such as unipolar depression and post-traumatic stress disorder (PTSD), occur more frequently in women than in men. Emerging research suggests that sex differences in receptors for the stress hormones, corticotropin releasing factor (CRF) and glucocorticoids, contribute to this disparity. For example, sex differences […]

Sex differences in stress-related receptors: [prime][prime]micro[prime][prime] differences with [prime][prime]macro[prime][prime] implications ...


Author: Enrico Erdas Background: Diagnosis of multiple endocrine neoplasia type 1 (MEN1) is commonly based on clinical criteria, and confirmed by genetic testing. In patients without known MEN1-related germline mutations, the possibility of a casual association between two or more endocrine tumors cannot be excluded and subsequent management may be […]

Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type ...



Author: Ornella Guardamagna The cardiovascular disease represents the leading cause of morbidity and mortality in Western countries and it is related to the atherosclerotic process. Cardiovascular disease risk factors, such as dyslipidemia, hypertension, insulin resistance, obesity, accelerate the atherosclerotic process which begins in childhood and progresses throughout the life span. […]

Impact of nutrition since early life on cardiovascular prevention


Author: Hugo Olmedillas Background: Cycling is considered to be a highly beneficial sport for significantly enhancing cardiovascular fitness in individuals, yet studies show little or no corresponding improvements in bone mass. Methods: A scientific literature search on studies discussing bone mass and bone metabolism in cyclists was performed to collect […]

Cycling and bone health: a systematic review