Congestive Heart Failure


Author: Xiaoping Li Background: Circulating N-terminal pro-B-type natriuretic peptide (NT pro-BNP), high- sensitivity C-reactive protein (hs-CRP) and big endothelin (big-ET) have been shown to be increased in heart failure and to contribute to both hemodynamic deterioration and cardiovascular remodeling. Here, we examined the prognostic value of the three neurohormones at […]

Plasma NT pro-BNP, hs-CRP and big-ET levels at admission as ...


Author: Arezoo Daryadel Background: Left ventricular hypertrophy (LVH) is a potent risk factor for sudden death and congestive heart failure. Methods: We tested the effect of sorafenib, a multikinase inhibitor (10 mg/kg, given orally, starting 2 days prior to banding, till sacrifice on day 14), on the development of LVH […]

Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in ...



Author: R Preston Mason Background: Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebivolol-stimulated bioavailable NO are not fully understood. Methods: Using amperometric NO and peroxynitrite (ONOO-) nanosensors, beta3-receptor (agonist: […]

The favorable kinetics and balance of nebivolol-stimulated nitric oxide and ...


Author: John W Petersen Background: Standard measures of left ventricular systolic and diastolic function often fail to identify left ventricular dysfunction in patients with heart failure and do not correlate with measures of functional capacity.Aim: To determine if speckle tracking echocardiography (STE)–determined measures of global and regional myocardial contractility have […]

Speckle tracking echocardiography-determined measures of global and regional left ventricular ...



Author: John B Porter Background: Established heart failure in thalassaemia major has a poor prognosis and optimal management remains unclear. Methods: A 1 year prospective study comparing deferoxamine (DFO) monotherapy or when combined with deferiprone (DFP) for patients with left ventricular ejection fraction (LVEF) <56% was conducted by the Thalassemia […]

Treatment of heart failure in adults with thalassemia major: response ...


Author: Charlotte Rigaud Background: This study describes the natural history of Barth syndrome (BTHS). Methods: The medical records of all patients with BTHS living in France were identified in multiple sources and reviewed. Results: We identified 16 BTHS pedigrees that included 22 patients. TAZ mutations were observed in 15 pedigrees. […]

Natural history of Barth syndrome: a national cohort study of ...



Author: Anders Sommer Background: Cardiac resynchronization therapy (CRT) is an established treatment in heart failure patients. However, a large proportion of patients remain nonresponsive to this pacing strategy. Left ventricular (LV) lead position is one of the main determinants of response to CRT. This study aims to clarify whether multimodality […]

Empiric versus imaging guided left ventricular lead placement in cardiac ...


Author: Aibek E Mirrakhimov Background: Obstructive sleep apnea (OSA) is a common disease, affecting approximately 2% of women and 4% of men residing in Western communities. No systematically reviewed data are available about the prevalence of this disease in Asia, the most heavily populated continent. Methods: PubMed/Medline, Scopus and Google […]

Prevalence of obstructive sleep apnea in Asian adults: a systematic ...



Author: Tomislav Letilovic Background: Cachexia is a state of involuntary weight loss common to many chronic diseases. Experimental data, showing that cachexia is related to the enhancement of acute phase response reaction, led to the new definition of cachexia that included, aside from the principal criterion of weight loss, other […]

Differences in routine laboratory parameters related to cachexia between patients ...


The impact of multiple chronic diseases on ambulatory care use; a population based study in Ontario, Canada Author: Elizabeth Muggah Background: The prevalence of multiple chronic diseases is increasing and is a common problem for primary health care providers. This study sought to determine the patient and health system burden […]

The impact of multiple chronic diseases on ambulatory care use; ...