Immunologic Disorders


Author: Hannah Cottom IntroductionInclusions of ectopic breast tissue in axillary lymph nodes are reported very infrequently and typically are only identified microscopically as an incidental finding. Furthermore the development of a benign proliferative lesion in the form of an intraductal papilloma from intranodal ectopic breast tissue is an extremely rare […]

Intraductal papilloma in an axillary lymph node of a patient ...


Author: Kelong Ma Background: Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon are unclear. Methods: miR-638 and SRY-box 2 (SOX2) expression levels were detected in 36 tumor samples and their […]

Loss of miR-638 in vitro promotes cell invasion and a ...



Author: Ning Wen Background: The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expression levels of FOXM1 in epithelial ovarian cancer (EOC), to identify the relationship between FOXM1 […]

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell ...


Author: Yan-Li Li Background: Despite the use of modern immunochemotherapy regimens, a significant proportion of diffuse large B-cell lymphoma (DLBCL) patients will relapse. We proposed absolute lymphocyte count/absolute monocyte count ratio (ALC/AMC ratio) as a new prognostic factor in relapsed or primary refractory DLBCL. Methods: We retrospectively analyzed 163 patients […]

Peripheral blood lymphocyte/monocyte ratio at the time of first relapse ...



Author: Hidetaka Noma Background: The association of inflammatory factors and the aqueous flare value with macular edema in branch retinal vein occlusion (BRVO) patients remains unclear. The relationship between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, […]

Role of Inflammation in Previously Untreated Macular Edema with Branch ...


Author: Kangsheng Tu Background: The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation. However, the clinical significance of Fbxw7 and the mechanisms involved in the anti-cancer effect of Fbxw7 in HCC are not clear.MethodThe Fbxw7 and YAP expression […]

Fbxw7 is an independent prognostic marker and induces apoptosis and ...



Author: Xin Xu Background: Emerging evidence has suggested that dysregulation of miR-182-5p may contribute to tumor development and progression in several types of human cancers. However, its role in renal cell carcinoma (RCC) is still unknown. Methods: Quantitative RT-PCR was used to quantify miR-182-5p expression in RCC clinical tissues. Bisulfite […]

Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via ...


Author: Kristin Pogoda Background: Gap junctional calcium signal propagation (transfer of calcium or a calcium releasing messenger via gap junctions) between vascular cells has been shown to be involved in the control of vascular tone. We have shown before that nitric oxide (NO) inhibits gap junctional communication in HeLa cells […]

NO, via its target Cx37, modulates calcium signal propagation selectively ...



Author: Mathieu Amand Background: DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, […]

DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase


Author: Periklis Panagopoulos IntroductionLeptospirosis is a zoonosis caused by the spirochete, Leptospira interrogans. While most cases of leptospirosis are mild to moderate, the course may be complicated by multiorgan dysfunction. We present a rare case of leptospirosis with acute myocarditis, pancreatitis, polyarthritis, mononeuritis multiplex and severe vasculitis with necrosis of […]

Myocarditis, pancreatitis, polyarthritis, mononeuritis multiplex and vasculitis with symmetrical peripheral ...



Author: Kavish J Bhansing IntroductionThe objective was to characterize the clinical and myopathological features of patients with scleroderma-polymyositis (SSc-PM) overlap compared to a population of patients with systemic sclerosis (SSc) and polymyositis (PM). Methods: A three-way comparison of patients with SSc-PM overlap (n = 25) with patients with SSc (n […]

Scleroderma-polymyositis overlap syndrome versus idiopathic polymyositis and systemic sclerosis: a ...


Author: Lei Shang Background: RIP3 (Receptor-interacting protein 3) pathway was mainly described as the molecular mechanism of necroptosis (programmed necrosis). But recently, non-RIP3 pathways were found to mediate necroptosis. We deliberate to investigate the effect of calpain, a molecule to induce necroptosis as reported (Cell Death Differ 19:245-256, 2012), in […]

Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following ...



Author: Heyang Xu Background: Tumor-associated macrophages (TAMs) are known to promote cancer progression and metastasis through the release of a variety of cytokines. Phosphatase of regenerating liver (PRL-3) has been considered as a marker of colorectal cancer (CRC) liver metastasis. Our previous research suggests that PRL-3 can enhance the metastasis […]

Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo ...


Author: Olga Kazarin Background: Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate chains of proteoglycans, resulting in the disassembly of the extracellular matrix. Heparanase has a central role in the development of various tumors, and its expression has been associated with increased tumor growth, angiogenesis and metastasis, but there is […]

Expression of heparanase in soft tissue sarcomas of adults



Author: Benjamas Wichapoon Background: The process of cytoadhesion in Plasmodium falciparum malaria infection causes signaling processes that lead to structural and functional changes at the cellular level. Histopathological changes of acute kidney injury (AKI) in P. falciparum malaria often involve glomerular proliferation, thickening of the glomerular basement membrane, acute tubular […]

Glomerular changes and alterations of zonula occludens-1 in the kidneys ...


Author: Christopher A Robinson Acute hemorrhagic leukoencephalitis (AHL) is a fulminant demyelinating disease of unknown etiology. Most cases are fatal within one week from onset. AHL pathology varies with the acuteness of disease. Hemorrhages, vessel fibrinoid necrosis, perivascular fibrin exudation, edema and neutrophilic inflammation are early features, while perivascular demyelination, […]

Early and widespread injury of astrocytes in the absence of ...



Author: Hao Zhang Background: We investigated the expression status of AGBL2 and its inhibitor latexin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. Methods: CD44+/CD24- tumor cells (CSC) from clinical specimens were sorted using flow cytometry. AGBL2 expression status […]

Clinical implications of AGBL2 expression and its inhibitor latexin in ...


Author: Asfandyar Sheikh Most therapeutic regimens are aimed at the use of pharmacologic agents or the induction of immunological response against the pathological agent. However, these methods tend to be insufficient for the management of some of the most debilitating infectious diseases. Here we present a novel therapeutic approach. It […]

Virus against Virus (VIVI): a potential solution against HIV/AIDS



Author: Arouna Omar IntroductionThis report documents a rare case of Chryseobacterium indologenes urinary tract infection in Senegal. Chryseobacterium indologenes is an uncommon human pathogen reported in hospital outbreaks in Taiwan and there have been some sporadic cases reported in Europe and in the USA mainly from immune-suppressed patients.Case presentationThis case […]

Chryseobacterium indologenes in a woman with acute leukemia in Senegal: ...


Author: Rooyen T Mavenyengwa Background: Transfusion Transmissible Infections (TTIs) such as Human Immunodeficiency Virus (HIV), syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV) are infections which are common in some communities in Southern Africa. It is important to screen blood donations for these infections. Methods: This is a […]

Prevalence of human immunodeficiency virus, syphilis, hepatitis B and C ...



Author: Shuji Kitahara Background: Vasohibin-2 (VASH2) has been identified as an endogenous and vascular endothelial growth factor (VEGF)-independent angiogenic factor that is highly expressed in tumor cells. In the present study, we aimed to determine whether pre-existing vascular changes can be used to predict tumor transformation as benign or malignant. […]

Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing ...


Author: Ana Moreto Background: Serious infections are common in patients undergoing autologous stem cell transplantation (ASCT) mainly because of the effects of immunosuppression. The innate immune system plays an important role in the defense against different infections. Mannose binding lectin (MBL) is a central molecule of the innate immune system. […]

Mannose-binding lectin gene variants and infections in patients receiving autologous ...



Author: Christos G Kostopoulos Background: Depending on their anatomical location, different fat depots have a different capacity to produce bioactive peptides, called adipokines. Adipokines produced by periadventitial fat have been implicated in the pathogenesis of vascular disease, including atherosclerosis. Chemerin is an adipokine with an established role in immunity, adipose […]

Chemerin and CMKLR1 expression in human arteries and periadventitial fat: ...


Author: Harutaka Katano Background: Opportunistic infections and malignancies such as malignant lymphoma and Kaposi sarcoma are significant complications of human immunodeficiency virus (HIV) infection. However, following the introduction of antiretroviral therapy in Japan in 1997, the incidence of clinical complications has decreased. In the present study, autopsy cases of HIV […]

The prevalence of opportunistic infections and malignancies in autopsied patients ...