Author: Janneke Snetselaar Background: The increasing global threat of Dengue demands new and easily applicable vector control methods. Ovitraps provide a low-tech and inexpensive means to combat Dengue vectors. Here we describe the development and optimization process of a novel contamination device that targets multiple life-stages of the Aedes aegypti […]

Development and evaluation of a novel contamination device that targets ...

Author: Krittikorn Kümpornsin Background: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1) is […]

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

Author: Tamires Aparecida Bittencourt Background: Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, […]

Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and ...

Author: Syed Rahin Ahmed Background: Engineered multifunctional nanoparticles (NPs) have made a tremendous impact on the biomedical sciences, with advances in imaging, sensing and bioseparation. In particular, the combination of optical and magnetic responses through a single particle system allows us to serve as novel multimodal molecular imaging contrast agents […]

Quantum dots incorporated magnetic nanoparticles for imaging colon carcinoma cells

Author: José P Pinto Background: Rational approaches for Metabolic Engineering (ME) deal with the identification of modifications that improve the microbes’ production capabilities of target compounds. One of the major challenges created by strain optimization algorithms used in these ME problems is the interpretation of the changes that lead to […]

TNA4OptFlux — a software tool for the analysis of strain ...

Author: Cordula Pertl Background: Duchenne Muscular Dystrophy is an inherited degenerative neuromuscular disease characterised by rapidly progressive muscle weakness. Currently, curative treatment is not available. Approaches for new treatments that improve muscle strength and quality of life depend on preclinical testing in animal models. The mdx mouse model is the […]

A new web-based method for automated analysis of muscle histology

Author: Esmaeil Shahsavand Ananloo Background: There are some reports on the effects of antidepressants on metabolic syndrome. However, our search in the previously published literature showed a lack of information on the comparison of the effects of different classes of antidepressants on lipid profile. Therefore, this study was aimed to […]

Comparing the effects of fluoxetine and imipramine on total cholesterol, ...