Lung Cancer


Author: Mitsunori Higuchi Background: Video-assisted thoracic surgery (VATS) lobectomy is a standard treatment for lung cancer. This study retrospectively compared long-term outcomes after VATS lobectomy versus lobectomy via open thoracotomy for clinical stage IA non-small cell lung cancer (NSCLC). Methods: From July 2002 to June 2012, 160 patients were diagnosed […]

Long-term outcomes after video-assisted thoracic surgery (VATS) lobectomy versus lobectomy ...


Author: Rosario M Piro Background: Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes’ interactions on which a pathway’s cellular function depends. In contrast, PathWave has been developed for the analysis of high-throughput gene expression data that explicitly […]

Network topology-based detection of differential gene regulation and regulatory switches ...



Author: Jitendra Kanodia Background: The Fibroblast Growth Factor (FGF) pathway is driving various aspects of cellular responses in both normal and malignant cells. One interesting characteristic of this pathway is the biphasic nature of the cellular response to some FGF ligands like FGF2. Specifically, it has been shown that phenotypic […]

Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic ...


Author: Sudjit Luanpitpong Background: Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects are a major concern. The objective of this study was to address human lung cancer risks associated with chronic pulmonary exposure to single-walled […]

Induction of stem-like cells with malignant properties by chronic exposure ...



Author: Kaiissar Mannoor Background: Non-small cell lung cancer (NSCLC) is the number one cancer killer. Tumor-initiating cells (TICs) are responsible for tumor progression and recurrence. Emerging evidences suggest that small nucleolar RNAs (snoRNAs) play malfunctioning roles in lung tumorigenesis. This study aims to determine if snoRNAs have important function in […]

Small nucleolar RNA signatures of lung tumor-initiating cells


Author: Yuqiao Zhou Purpose: Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1alpha gene single nucleotide polymorphisms (SNPs) are implicated to be associated with cancer risks. However, results from the published studies remained inconclusive. The aim of this study is to investigate the […]

The association between hypoxia-inducible factor-1 alpha gene G1790A polymorphism and ...



Author: Harutaka Katano Background: Opportunistic infections and malignancies such as malignant lymphoma and Kaposi sarcoma are significant complications of human immunodeficiency virus (HIV) infection. However, following the introduction of antiretroviral therapy in Japan in 1997, the incidence of clinical complications has decreased. In the present study, autopsy cases of HIV […]

The prevalence of opportunistic infections and malignancies in autopsied patients ...


Author: Britta Weber Background: Lung cancer patients with mutations in the epidermal growth factor receptor (EGFR) are primary candidates for EGFR-targeted therapy. Reliable analyses of such mutations have previously been possible only in tumour tissue. Here, we demonstrate that mutations can be detected in plasma samples with allele-specific PCR assays. […]

Detection of EGFR mutations in plasma and biopsies from non-small ...



Author: Aishah Coyte Background: There is evidence that cancer survivors are at increased risk of second primary cancers. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks. Methods: We examined the incidence of second primary cancer among adults in the West of Scotland, […]

Second primary cancer risk – the impact of applying different ...


Author: Xiao-Lei Li Background: Oct4 is a major transcription factor related to stem cell self-renewal and differentiation. To fulfill its functions, it must be able to enter the nucleus and remain there to affect transcription. KPNA2, a member of the karyopherin family, plays a central role in nucleocytoplasmic transport. The […]

Downregulation of KPNA2 in non-small-cell lung cancer is associated with ...



Author: Duan Mengxi Background: Ras association domain family 1A gene (RASSFlA) is a candidate suppressor gene, Lack of RASSF1A expression was found in lung cancer. High DNA methylation at the promoter region is the main reason for inactivating RASSR1A transcription. Methods: In this study, we examined RASSF1A’s methylation status and […]

Effect of DNA methylation inhibitor on RASSF1A genes expression in ...


Author: Katsuji Sawai We report here a case of partial response to hepatic arterial infusion chemotherapy in a patient who developed serious hepatic failure due to unresectable colorectal cancer and hepatic metastasis and showed resistance to systemic chemotherapy with molecular targeted drugs, mFOLFOX6, and FOLFIRI. The patient was a 60-year-old […]

Partial response after transcatheter arterial infusion chemotherapy in a patient ...



Author: Harald Rief Background: The objective of this retrospective analysis is to systematically assess osseous lesions on the basis of a validated scoring system in terms of stability and fractures prior to and following radiotherapy in 338 lung cancer patients with bone metastases in the vertebral column. Methods: The stability […]

The stability of osseous metastases of the spine in lung ...


Author: Yue-E Liu Background: Increasing the radiotherapy dose can result in improved local control for non-small-cell lung cancer (NSCLC) and can thereby improve survival. Accelerated hypofractionated radiotherapy can expose tumors to a high dose of radiation in a short period of time, but the optimal treatment regimen remains unclear. The […]

High-dose accelerated hypofractionated three-dimensional conformal radiotherapy (at 3 Gy/fraction) with ...



Author: Yuri Ito Background: We usually report five-year survival from population-based cancer registries in Japan; however these survival estimates may be pessimistic for cancer survivors, because many patients with unfavourable prognosis die shortly after diagnosis. Conditional survival can provide relevant information for cancer survivors, their family and oncologists. Methods: We […]

Conditional survival for longer-term survivors from 2000–2004 using population-based cancer ...


Author: Abigail T Berman IntroductionPost-operative radiotherapy (PORT) for stage IIIA completely-resected non-small cell lung cancer (CR-NSCLC) has been shown to improve local control; however, it is unclear that this translates into a survival benefit. One explanation is that the detrimental effect of PORT on critical organs at risk (OARs) negates […]

An in-silico comparison of proton beam and IMRT for postoperative ...



Author: Seied Mojtaba Valiahdi Background: Ferula species are reputed in folk medicine for the treatment of a variety of disorders. There have been sporadic reports on the chemopreventive and chemosensitizing activities of some terpenoid coumarin derivatives from the genus Ferula. The present study investigated the cytotoxic activity of 11 phytochemicals […]

Cytotoxic activities of phytochemicals from Ferula species


Author: Ji-fu Liu Background: Nuclear factor of activated T-cells (NFAT) is a general name applied to a family of transcription factors shown to be important in immune response. One or more members of the NFAT family are expressed in most cells of the immune system. NFAT1 is considered to involve […]

Depleting NFAT1 expression inhibits the ability of invasion and migration ...



Author: Xi-Qing Li Background: Although the prognostic roles of beta-catenin expression in non-small cell lung cancer (NSCLC) have been reported in several immunohistochemical (IHC) studies, the results were not consistent because some studies lack sufficient number of the positive cases or did not evaluate the subcellular localization features of the […]

Nuclear beta-catenin accumulation is associated with increased expression of Nanog ...


Author: Stephanie Weibel Background: Malignant pleural effusion (MPE) is associated with advanced stages of lung cancer and is mainly dependent on invasion of the pleura and expression of vascular endothelial growth factor (VEGF) by cancer cells. As MPE indicates an incurable disease with limited palliative treatment options and poor outcome, […]

Treatment of malignant effusion by oncolytic virotherapy in an experimental ...



Author: Alexander M Busch Background: New pharmacologic targets are urgently needed to treat or prevent lung cancer, the most common cause of cancer death for men and women. This study identified one such target. This is the canonical Wnt signaling pathway, which is deregulated in cancers, including those lacking adenomatous […]

Evidence for tankyrases as antineoplastic targets in lung cancer


Author: Spyridon Gennatas Background: Single arm phase 1 and 2 studies on Crizotinib in ALK-positive patients so far have shown rapid and durable responses. Spontaneous pneumothoraces as a result of response to anti-cancer therapy are rare in oncology but have been documented in a number of tumour types including lung […]

Early pneumothorax as a feature of response to crizotinib therapy ...



Author: Luo Hu Background: Lung cancer is still the leading cause of cancer-related mortality worldwide. Around 80 to 85 % of lung cancers are non-small cell lung cancer (NSCLC). Regional lymphatic metastasis is a frequent occurrence in NSCLC, and the extent of lymphatic dissemination significantly determines the prognosis of patients […]

Assessing the effectiveness and safety of liposomal paclitaxel in combination ...


Author: Ayan Sen Expanded abstractCitationBoomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS: Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306:2594-2605. Background: Severe sepsis […]

Towards personalized medicine in sepsis: Quest for Shangri-La?