Author: Flora Tzifi Background: Data regarding the quantitative expression of TCR Vbeta subpopulations in children with autoimmune diseases provided interesting and sometimes conflicting results. The aim of the present study was to assess by comparative flow cytometric analysis the peripheral blood CD4+ TCR Vbeta repertoire of children with an organ-specific […]

Flow cytometric analysis of the CD4+ TCR Vbeta repertoire in ...

Author: Natasha Jordan Conventional immunosuppressive therapies have radically transformed patient survival in Systemic Lupus Erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade […]

Novel therapeutic agents in clinical development for Systemic Lupus Erythematosus

Author: Margareta Lantow IntroductionAn NZB-derived genetic locus (Sle2c2) that suppresses autoantibody production in a mouse model of induced systemic lupus erythematosus contains a polymorphism in the gene encoding the G-CSF receptor. This study was designed to test the hypothesis that the Sle2c2 suppression is associated with an impaired G-CSF receptor […]

The granulocyte colony stimulating factor pathway regulates autoantibody production in ...

Author: Hans-Joachim Anders In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunction may be caused by lupusunrelated renal injury […]

Kidney disease in lupus is not always 'lupus nephritis'

Author: Venkat Reddy B cells are believed to be central to the disease process in systemic lupus erythematosus (SLE), making them a target for new therapeutic intervention. In recent years there have been many publications regarding the experience in SLE of B-cell depletion utilising rituximab, an anti-CD20 mAb that temporarily […]

B-cell depletion in SLE: clinical and trial experience with rituximab ...

Author: Anisur Rahman Although renal biopsy is the most accurate way of assessing renal inflammation in patients with lupus nephritis (LN), it is invasive and cannot be done frequently. Currently used blood and urine biomarkers have limited utility in monitoring the activity of nephritis. In this issue Singh et al […]

Can measuring urinary biomarkers improve the management of lupus nephritis?

Author: Adam Morton A case of internal carotid artery dissection in a pregnant woman with Systemic Lupus Erythematosus (SLE) immediately following chiropractic treatment is presented. The literature regarding complications of neck manipulation during pregnancy, spontaneous dissection of craniocervical arteries in pregnancy and the postpartum period, and dissection of craniocervical arteries […]

Internal carotid artery dissection following chiropractic treatment in a pregnant ...

Author: Aisha Lateef Systemic lupus erythematosus (SLE) is an autoimmune disease of diverse manifestations, with onset usually in young women in the third to fourth decade of life. The chronic nature of this relapsing remitting disease leads to organ damage accrual over time. Mortality and morbidity are increased in patients […]

Unmet medical needs in systemic lupus erythematosus