Lympatic Disorders


Author: Hannah Cottom IntroductionInclusions of ectopic breast tissue in axillary lymph nodes are reported very infrequently and typically are only identified microscopically as an incidental finding. Furthermore the development of a benign proliferative lesion in the form of an intraductal papilloma from intranodal ectopic breast tissue is an extremely rare […]

Intraductal papilloma in an axillary lymph node of a patient ...


Author: Ning Wen Background: The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expression levels of FOXM1 in epithelial ovarian cancer (EOC), to identify the relationship between FOXM1 […]

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell ...



Author: Thomas Mücke Background: The evidence base to inform the decision making process in patients with early stage oral cancer and a clinical and radiological N0 neck remains insufficient to answer the question when it is safe to "watch and wait" and when to proceed with a selective neck dissection. […]

Incidence and outcome for patients with occult lymph node involvement ...


Author: Martin Sokol Background: Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies. In previous studies, the assignment of mouse genes to individual retroviral integration sites has been based on close proximity and expression patterns of […]

Novel principles of gamma-retroviral insertional transcription activation in murine leukemia ...



Author: Yan-Li Li Background: Despite the use of modern immunochemotherapy regimens, a significant proportion of diffuse large B-cell lymphoma (DLBCL) patients will relapse. We proposed absolute lymphocyte count/absolute monocyte count ratio (ALC/AMC ratio) as a new prognostic factor in relapsed or primary refractory DLBCL. Methods: We retrospectively analyzed 163 patients […]

Peripheral blood lymphocyte/monocyte ratio at the time of first relapse ...


Author: Tran Ngoc Dang Background: Dengue shock syndrome (DSS), a severe life-threatening form of dengue infection, mostly occurs in children. A recent genome wide association study (GWAS) identified two SNPs, rs3132468 of major histocompatibility complex class I polypeptide-related sequence B (MICB) and rs3765524 of phospholipase C, epsilon 1 (PLCE1), associated […]

A replication study confirms the association of GWAS-identified SNPs at ...



Author: Hung-Hsin Lin This report presents a case of collision tumors of low-grade B-cell lymphoma and adenocarcinoma in the sigmoid colon of an 81-year-old man. All surgically resected regional mesenteric lymph nodes were found to be occupied by low-grade B-cell lymphoma, and one lymph node showed the presence of adenocarcinoma. […]

Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis ...


Author: Shinro Hata Background: Pseudoaneurysms are caused by trauma, tumors, infections, vasculitis, atherosclerosis and iatrogenic complications. In this paper, we report about a patient with rupture of an external iliac artery pseudoaneurysm, which lead to hemorrhagic shock, after undergoing laparoscopic radical cystectomy and extended pelvic lymphadenectomy.Case presentationThe patient was a […]

Life-threatening rupture of an external iliac artery pseudoaneurysm caused by ...



Author: Hao Zhang Background: We investigated the expression status of AGBL2 and its inhibitor latexin in breast cancer stem cells and its clinical implications in order to lay a foundation for managing breast cancer. Methods: CD44+/CD24- tumor cells (CSC) from clinical specimens were sorted using flow cytometry. AGBL2 expression status […]

Clinical implications of AGBL2 expression and its inhibitor latexin in ...


Author: Maria Angela Diroma Background: Whole Exome Sequencing (WES) is one of the most used and cost-effective next generation technologies that allows sequencing of all nuclear exons. Off-target regions may be captured if they present high sequence similarity with baits. Bioinformatics tools have been optimized to retrieve a large amount […]

Extraction and annotation of human mitochondrial genomes from 1000 Genomes ...



Author: George L Balalis Lymph node status is the most important prognostic factor in esophageal cancer. Through improved detection of lymph node metastases, using the sentinel lymph node concept, accurate staging and more tailored therapy may be achieved. This review article outlines two principle ways in which the sentinel lymph […]

Sentinel lymph node biopsy in esophageal cancer: an essential step ...


Author: Yuqiao Zhou Purpose: Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1alpha gene single nucleotide polymorphisms (SNPs) are implicated to be associated with cancer risks. However, results from the published studies remained inconclusive. The aim of this study is to investigate the […]

The association between hypoxia-inducible factor-1 alpha gene G1790A polymorphism and ...



Author: Constantine James Konstantoulas Background: Mouse mammary tumor virus (MMTV) is a complex, milk-born betaretrovirus, which preferentially infects dendritic cells (DC) in the gastrointestinal tract and then spreads to T and B lymphocytes and finally to the mammary gland. It is not clear how the prototypic betaretrovirus infects mucosal DCs […]

Mouse mammary tumor virus-based vector transduces non-dividing cells, enters the ...


Author: Harutaka Katano Background: Opportunistic infections and malignancies such as malignant lymphoma and Kaposi sarcoma are significant complications of human immunodeficiency virus (HIV) infection. However, following the introduction of antiretroviral therapy in Japan in 1997, the incidence of clinical complications has decreased. In the present study, autopsy cases of HIV […]

The prevalence of opportunistic infections and malignancies in autopsied patients ...



Author: Florian Wirsdörfer Background: Lymphocyte infiltration is a common feature of radiation-induced pneumonitis and fibrosis, but their contribution to the pathogenic processes is still unclear. Here, we addressed the impact of thorax irradiation on the T cell compartment with a focus on immunosuppressive regulatory T cells (Treg). Methods: C57BL/6 wild […]

Thorax irradiation triggers a local and systemic accumulation of immunosuppressive ...


Author: Changsheng He Backgrounds: Extracorporeal membrane oxygenation (ECMO) has been recommended for treatment of acute, potentially reversible, life-threatening respiratory failure unresponsive to conventional therapy. Intestinal mucosal barrier dysfunction is one of the most critical pathophysiological disorders during ECMO. This study aimed to determine whether combination with CRRT could alleviate damage […]

Effects of continuous renal replacement therapy on intestinal mucosal barrier ...



Author: Li Shi T-cell activation and dysfunction relies on direct and modulated receptors. Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. We are beginning to understand the power […]

The role of PD-1 and PD-L1 in T-cell immune suppression ...


Author: Nathalie Accart Background: Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalance the Th2-immunosuppressive state associated with this pathology. In a phase I/II clinical trial, we correlated the local immune […]

Lymphocitic infiltration in the cutaneous lymphoma microenvironment after injection of ...



Author: Aeyung Kim Background: Samsoeum (SSE), a traditional herbal formula, has been widely used to treat cough, fever, congestion, and emesis for centuries. Recent studies have demonstrated that SSE retains potent pharmacological efficiency in anti-allergic and anti-inflammatory reactions. However, the anti-cancer activity of SSE and its underlying mechanisms have not […]

Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell ...


Author: Pankaj Tiwari Lymphedema remains a poorly understood entity that can occur after lymphadenectomy. Herein, we will review the pathogenesis of lymphedema, diagnostic modalities and the natural history of extremity involvement. We will review the incidence of upper extremity lymphedema in patients treated for breast malignancies and lower extremity lymphedema […]

Breast and gynecologic cancer-related extremity lymphedema: a review of diagnostic ...



Author: Anna Bachmayr-Heyda Background: Epithelial ovarian cancer is one of the most lethal gynecologic malignancies. Clinicopathological factors do not permit precise prognosis and cannot provide guidance to specific treatments. In this study we assessed tumor infiltrating CD8+ T cells in association with Ki67 proliferation index and evaluated their prognostic impact […]

Prognostic impact of tumor infiltrating CD8+ T cells in association ...


Author: Hans-Dieter Volk Several data support the view that impairment of the inflammatory-immune response is a hallmark of severe sepsis and the level and time of recovery to immunocompetence has a major impact on the clinical outcome of ICU patients. Recent studies demonstrate that improvement of anti-tumour immune response by […]

To be, or not to be immunocompetent



Author: Cornelia Brendel Background: Fragile X syndrome is caused by the loss of FMRP expression due to methylation of the FMR1 promoter. Treatment of fragile X syndrome patients’ lymphoblastoid cells with 5-azadeoxycytidine results in demethylation of the promoter and reactivation of the gene. The aim of the study was to […]

Methotrexate treatment of FraX fibroblasts results in FMR1 transcription but ...


Author: Elizabeth A Mann Background: Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates intracellular cGMP and is implicated in intestinal ion secretion, cell proliferation, apoptosis, intestinal barrier function, as […]

Guanylate cyclase C limits systemic dissemination of a murine enteric ...