Medical Research


Author: Robert P Baughman While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with […]

Goldilocks, vitamin D and sarcoidosis




Author: Ruijie Liu Background: SNP genotyping microarrays have revolutionized the study of complex disease. The current range ofcommercially available genotyping products contain extensive catalogues of low frequency and rarevariants. Existing SNP calling algorithms have difficulty dealing with these low frequency variants,as the underlying models rely on each genotype having a […]

KRLMM: an adaptive genotype calling method for common and low ...


Author: Kelong Ma Background: Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon are unclear. Methods: miR-638 and SRY-box 2 (SOX2) expression levels were detected in 36 tumor samples and their […]

Loss of miR-638 in vitro promotes cell invasion and a ...



Author: Thuc T Le Background: Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease. Prevention of tamoxifen-induced fatty liver has the potential to improve […]

Uridine prevents tamoxifen-induced liver lipid droplet accumulation


Author: Claire L Cleland Background: There is an urgent need to increase population levels of physical activity, particularly amongst those who are socio-economically disadvantaged. Multiple factors influence physical activity behaviour but the generalisability of current evidence to such ‘hard-to-reach’ population subgroups is limited by difficulties in recruiting them into studies. […]

Identifying solutions to increase participation in physical activity interventions within ...



Author: Stefano Stagi Background: A higher prevalence of coeliac disease (CD) has been reported in patients with Williams-Beuren syndrome (WBS), though coexistence with other autoimmune diseases has not been evaluated.ObjectiveThe aim of this study was to examine the prevalence of the more frequent autoimmune diseases and organ- and non-organ specific […]

Coeliac disease and risk for other autoimmune diseases in patients ...


Author: Boon K Yeo Background: The use of foot orthoses and in-shoe wedges in cycling are largely based on theoretical benefits and anecdotal evidence. This review aims to systematically collect all published research on this topic, critically evaluate the methodology and summarise the findings. Methods: Study inclusion criteria were: all […]

The effect of foot orthoses and in-shoe wedges during cycling: ...



Author: Hannah Cottom IntroductionInclusions of ectopic breast tissue in axillary lymph nodes are reported very infrequently and typically are only identified microscopically as an incidental finding. Furthermore the development of a benign proliferative lesion in the form of an intraductal papilloma from intranodal ectopic breast tissue is an extremely rare […]

Intraductal papilloma in an axillary lymph node of a patient ...


Author: Derek D Houston Background: Biogeographers seek to understand the influences of global climate shifts and geologic changes to the landscape on the ecology and evolution of organisms. Across both longer and shorter timeframes, the western North American landscape has experienced dynamic transformations related to various geologic processes and climatic […]

Investigating the effects of Pleistocene events on genetic divergence within ...



Author: Punita Sharma Background: In recent years, it has been well documented that gut flora not only influence mosquito physiology, but also significantly alter vector competency. Although, salivary gland and gut constitute key partners of the digestive system, it is still believed that salivary glands may harbor less flora than […]

Salivary glands harbor more diverse microbial communities than gut in ...


Author: Paulino Barragán-Iglesias Background: The participation of spinal P2X receptors in pain neuropathic is well recognized. However, the role of P2Y receptors has been less studied. The purpose of this study was to investigate the contribution of spinal P2Y6,11 receptors following peripheral nerve damage induced by spinal nerve ligation. In […]

Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain ...



Author: Qiuan Zhong Background: Body mass index (BMI) and hemoglobin (Hb) are positively associated with hypertensive disorders among pregnant women. The aim of this study was to estimate a potential interaction between high BMI and high Hb concentrations on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in pregnancy. […]

Interaction of body mass index and hemoglobin concentration on blood ...


Author: Andréa S Almeida Spatial heterogeneity in the incidence of visceral leishmaniasis (VL) is an important aspect to be considered in planning control actions for the disease. The objective of this study was to predict areas at high risk for visceral leishmaniasis (VL) based on socioeconomic indicators and remote sensing […]

Prediction of high-risk areas for visceral leishmaniasis using socioeconomic indicators ...



Author: Denglu Yan ObjectiveThis research aims to investigate magnetic resonance imaging (MRI) in the tibial epiphyseal growth plate development of Wistar rat. Methods: Fifty weanling Wistar rats were divided by a computerized blocking procedure into five groups. The rats received standard commercial feed with or without T-2 toxin additive, low-protein […]

Magnetic resonance imaging in the tibial epiphyseal growth plate development ...


Author: Angelo Compare Background: Evidence demonstrates that physical exercise and psychological wellbeing are closely interlinked, particularly in older-aged women. However, research investigating how different forms of exercise influence mental health in older-aged women is underdeveloped. Methods: A randomized controlled trial (N = 300) will assess the relative effectiveness of two […]

PAHA study: Psychological Active and Healthy Aging: psychological wellbeing, proactive ...



Author: Ning Wen Background: The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expression levels of FOXM1 in epithelial ovarian cancer (EOC), to identify the relationship between FOXM1 […]

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell ...


Author: Antonia Efstathiou Background: In search of new antiparasitic agents for overcoming the limitations of current leishmaniasis chemotherapy, we have previously shown that 6-bromoindirubin-3[prime]-oxime (6-BIO) and several other 6-substituted analogues of indirubin, a naturally occurring bis-indole present in mollusks and plants, displayed reverse selectivity from the respective mammalian kinases, targeting […]

An inhibitor-driven study for enhancing the selectivity of indirubin derivatives ...




Author: Thomas Mücke Background: The evidence base to inform the decision making process in patients with early stage oral cancer and a clinical and radiological N0 neck remains insufficient to answer the question when it is safe to "watch and wait" and when to proceed with a selective neck dissection. […]

Incidence and outcome for patients with occult lymph node involvement ...



Author: Hannah Maria Jennings Background: This paper explores the nature of food and plants and their meanings in a British Bengali urban context. It focuses on the nature of plants and food in terms of their role in home making, transnational connections, generational and concepts of health. Methods: An ethnographic […]

Food, home and health: the meanings of food amongst Bengali ...


Author: Kaoru Kaseda Solitary papilloma of the lung is thought to be a rare benign epithelial tumor, and complete surgical resection is currently the standard treatment for this pathology. However, some cases of papilloma have reportedly shown malignant potential. We report two cases of solitary glandular papilloma of the peripheral […]

Solitary glandular papilloma of the peripheral lung: a report of ...



Author: Daniela da Silva Gonçalves Background: The bacterium Wolbachia is a promising agent for the biological control of vector-borne diseases as some strains have the ability to block the transmission of key human disease-causing pathogens. Fast, accurate and inexpensive methods of differentiating between infected and uninfected insects will be of […]

Wolbachia detection in insects through LAMP: loop mediated isothermal amplification


Author: Ikuko Fujisaki Background: Understanding movement patterns of free-ranging top predators throughout heterogeneous habitat is important for gaining insight into trophic interactions. We tracked the movements of five adult American alligators to delineate their estuarine habitat use and determine drivers of their activity patterns in a seasonally-fluctuating environment. We also […]

Home range and movements of American alligators (Alligator mississippiensis) in ...