Nervous System


Author: Thuc T Le Background: Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease. Prevention of tamoxifen-induced fatty liver has the potential to improve […]

Uridine prevents tamoxifen-induced liver lipid droplet accumulation


Author: Paulino Barragán-Iglesias Background: The participation of spinal P2X receptors in pain neuropathic is well recognized. However, the role of P2Y receptors has been less studied. The purpose of this study was to investigate the contribution of spinal P2Y6,11 receptors following peripheral nerve damage induced by spinal nerve ligation. In […]

Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain ...



Author: Daniela da Silva Gonçalves Background: The bacterium Wolbachia is a promising agent for the biological control of vector-borne diseases as some strains have the ability to block the transmission of key human disease-causing pathogens. Fast, accurate and inexpensive methods of differentiating between infected and uninfected insects will be of […]

Wolbachia detection in insects through LAMP: loop mediated isothermal amplification


Author: Ikuko Fujisaki Background: Understanding movement patterns of free-ranging top predators throughout heterogeneous habitat is important for gaining insight into trophic interactions. We tracked the movements of five adult American alligators to delineate their estuarine habitat use and determine drivers of their activity patterns in a seasonally-fluctuating environment. We also […]

Home range and movements of American alligators (Alligator mississippiensis) in ...



Author: Jing Zhao Background: The novel Femtosecond lenticule extraction (FLEx) procedure has been considered safe, predictable, and effective in treating myopia and myopic astigmatism, with few complications. However, an enhancement procedure after FLEx may be required in some cases, but has not been reported in detail.Case presentationA 24-year-old woman who […]

Enhancement of femtosecond lenticule extraction for visual symptomatic eye after ...


Author: Punita Bhansali Background: Proper binocular vision depends on the routing at the optic chiasm of the correct proportion of retinal ganglion cell (RGC) axons that project to the same (ipsilateral) and opposite (contralateral) side of the brain. The ipsilateral RGC projection is reduced in mammals with albinism, a congenital […]

Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion ...



Author: Johannes Thome Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This "progress" of molecular psychiatry, however, is to a degree "unilateral" and "epiphytic" should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of […]

Decennium of Karl Jaspers's general psychopathology: implications for molecular psychiatry


Author: Tsung-I Chen Background: Intermittent hypoxia (IH) plays a critical role in sleep breathing disorder-associated hippocampus impairments, including neurocognitive deficits, irreversible memory and learning impairments. IH-induced neuronal injury in the hippocampus may result from reduced precursor cell proliferation and the relative numbers of postmitotic differentiated neurons. However, the mechanisms underlying […]

Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation ...



Author: Camille Bismuth Background: Subarachnoid cysts are rare conditions in veterinary medicine, associated with spinal cord dysfunction. Most of the 100 cases of subarachnoid cysts described since the first report in 1968 were apparently not true cysts. True cysts are usually situated in the cervical area and occur in predisposed […]

Original surgical treatment of thoracolumbar subarachnoid cysts in six chondrodystrophic ...


Author: Jitendra Kanodia Background: The Fibroblast Growth Factor (FGF) pathway is driving various aspects of cellular responses in both normal and malignant cells. One interesting characteristic of this pathway is the biphasic nature of the cellular response to some FGF ligands like FGF2. Specifically, it has been shown that phenotypic […]

Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic ...



Author: Goro Tanifuji Background: Nucleomorphs are residual nuclei derived from eukaryotic endosymbionts in chlorarachniophyte and cryptophyte algae. The endosymbionts that gave rise to nucleomorphs and plastids in these two algal groups were green and red algae, respectively. Despite their independent origin, the chlorarachniophyte and cryptophyte nucleomorph genomes share similar genomic […]

Nucleomorph and plastid genome sequences of the chlorarachniophyte Lotharella oceanica: ...


Author: Hendrik Ballhausen Background: Metal implants, surgical clips and other foreign bodies may cause ‘streaking’ or ‘star’ artifacts in computed tomography (CT) reconstructions, for example in the vicinity of dental restorations or hip implants. The deteriorated image quality complicates contouring and has an adverse effect on quantitative planning in external […]

Post-processing sets of tilted CT volumes as a method for ...



Author: Christopher D Maroules Background: Cardiovascular magnetic resonance (CMR) has been validated for the noninvasive assessment of total arterial compliance and aortic stiffness, but their associations with cardiovascular outcomes is unknown. The purpose of this study was to evaluate associations of CMR measures of total arterial compliance and two CMR […]

Cardiovascular outcome associations among cardiovascular magnetic resonance measures of arterial ...




Author: Xinyuan Zhang Diabetic macular edema (DME), a serious eye complication caused primarily by hyperglycemia, is one of the major causes of blindness. DME, which is characterized by cystic retinal thickening or lipid deposition, is prone to relapse after successful treatment. DME is a complex pathological process caused by multiple […]

Diabetic macular edema: new concepts in patho-physiology and treatment




Author: Daria Sanna Background: Here we report the first insight into the mitochondrial (Cytochrome c Oxidase subunit I – COI and Cytochrome b – Cyt b) genetic variation of the only Mediterranean cephalocarid Lightiella magdalenina.FindingsCOI sequences provide a scenario of low intraspecific variability, while significant genetic divergence occurs between L. […]

First insights on the mitochondrial genetic variability of Lightiella magdalenina ...


Author: Kavish J Bhansing IntroductionThe objective was to characterize the clinical and myopathological features of patients with scleroderma-polymyositis (SSc-PM) overlap compared to a population of patients with systemic sclerosis (SSc) and polymyositis (PM). Methods: A three-way comparison of patients with SSc-PM overlap (n = 25) with patients with SSc (n […]

Scleroderma-polymyositis overlap syndrome versus idiopathic polymyositis and systemic sclerosis: a ...



Author: Ruijin Shao Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of anti-cancer action in the endometrium of women with polycystic ovary syndrome (PCOS) have not yet been fully elucidated. Organic […]

Direct effects of metformin in the endometrium: a hypothetical mechanism ...


Author: Yu Ye Background: The aim of this study is to investigate quantitative outcome measurements of hand motor performance for subjects after mild to moderate stroke using grip control tasks and characterize abnormal flexion synergy of upper extremities after stroke. Methods: A customized dynamometer with force sensors was used to […]

Kinetic measurements of hand motor impairments after mild to moderate ...



Author: Xiaoping Li Background: Circulating N-terminal pro-B-type natriuretic peptide (NT pro-BNP), high- sensitivity C-reactive protein (hs-CRP) and big endothelin (big-ET) have been shown to be increased in heart failure and to contribute to both hemodynamic deterioration and cardiovascular remodeling. Here, we examined the prognostic value of the three neurohormones at […]

Plasma NT pro-BNP, hs-CRP and big-ET levels at admission as ...


Author: Yu Shanshan Background: Posterior microphthalmos combined with acquired retinoschisis is a rare entity. This report presents a case of acquired retinoschisis in a patient with posterior microphthalmos and discusses the management for such disease. The patient exhibited acquired peripheral retinal schisis in both eyes.Case presentationThe patient presented with a […]

Acquired retinoschisis resolved after 23Gage pars plana vitrectomy in posterior ...



Author: Muqing Yi Background: Almonds are a healthy tree nut food with high nutrient density. Their consumption has been shown to ameliorate oxidative stress, inflammation, etc. The objective of the study was to examine the effect of almonds on elements of endurance exercise performance in trained athletes. Methods: A 10-week […]

The effect of almond consumption on elements of endurance exercise ...


Author: Paul Blankman IntroductionThis study compares different parameters derived from electrical impedance tomography (EIT) data to define ‘best’ positive end-expiratory pressure (PEEP) during a decremental PEEP trial in mechanically-ventilated patients. ‘Best’ PEEP is regarded as minimal lung collapse and overdistention in order to prevent ventilator-induced lung injury. Methods: A decremental […]

Detection of 'best' positive end-expiratory pressure derived from electrical impedance ...