Osteoporosis


Author: Robert P Baughman While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with […]

Goldilocks, vitamin D and sarcoidosis


Author: Kriangkrai Wittayapairoj Background: Failure of pedicle screw fixation is often seen in patients with severe osteoporosis. We developed new lumbar spinal instrumentation (Tadpole system) for elderly patients who have osteoporotic bone and poor general health status. The objective of this study was to document the long-term clinical outcomes after […]

Long-term result of posterolateral fusion of the lumbar spine using ...



Author: Chun-Kai Chiu Background: To investigate adherence and patient-specific factors associated with poor compliance with osteoporosis regimens among men. Methods: In this retrospective chart review study, we collected data on male patients with osteoporosis treated in accordance with therapeutic recommendations. Adherence was determined by the compliance and persistence of those […]

Adherence to osteoporosis regimens among men and analysis of risk ...


Author: Östen Ljunggren Background: To describe changes in health-related quality of life (HRQoL) of postmenopausal women with osteoporosis treated with teriparatide for up to 18 months and followed-up for a further 18 months, and to assess the influence of recent prior and incident fractures. Methods: The European Forsteo Observational Study […]

Effective osteoporosis treatment with teriparatide is associated with enhanced quality ...



Author: Jadwiga A Wedzicha Exacerbations of chronic obstructive pulmonary disease (COPD) are important events that carry significant consequences for patients. Some patients experience frequent exacerbations, and are now recognized as a distinct clinical subgroup, the ‘frequent exacerbator’ phenotype. This is relatively stable over time, occurs across disease severity, and is […]

Mechanisms and impact of the frequent exacerbator phenotype in chronic ...


Author: Mohammed Uddin Background: The primary objective of this study is to identify novel copy number variations (CNVs) associated with familial ankylosing spondylitis (AS). A customized genome-wide microarray was designed to detect CNVs and applied to a multiplex AS family with six (6) affected family members. CNVs were detected using […]

UGT2B17 copy number gain in a large ankylosing spondylitis multiplex ...



Author: Xiaoming Wu Background: Osteoporosis affects 200 million people worldwide and places an enormous economic burden on society. We aim to identify the feature genes that are related to osteoprotegerin in osteoporosis and to perform function analysis with DNA microarray from human bone marrow. Methods: We downloaded the gene expression […]

Screening of osteoprotegerin-related feature genes in osteoporosis and functional analysis ...


Author: Mercè Giner Background: Osteoporosis is a metabolic disorder characterized by a reduction in bone mass and deterioration in the microarchitectural structure of the bone, leading to a higher risk for spontaneous and fragility fractures.The main aim was to study the differences between human bone from osteoporotic and osteoarthritic patients […]

Differences in osteogenic and apoptotic genes between osteoporotic and osteoarthritic ...