Parkinson’s Disease


Author: Sasa Badzek Objectives: To refresh clinical diagnostic dilemmas in patients presenting with symptoms resembling to those of parkinsonism, to report rare association of colon cancer and paraneoplastic stiff person syndrome (SPS), and to draw attention on the possible correlation of capecitabine therapy with worsening of paraneoplastic SPS. Methods: Case […]

Paraneoplastic stiff person syndrome associated with colon cancer misdiagnosed as ...


Author: Heqi Cao This review is to analyze the role of National Natural Science Foundation of China (NSFC) on the development of basic research of Parkinson’s disease from 1990 to 2012. Data on the total number of projects and funding of NSFC allocated to Parkinson’s disease, as well as hotspots […]

Progress of basic research in Parkinson's disease in China: data ...



Author: David B Teplow According to Thomas Kuhn, the success of ‘normal science,’ the science we all practice on a daily basis, depends on the adherence to, and practice of, a paradigm accepted by the scientific community. When great scientific upheavals occur, they involve the rejection of the current paradigm […]

On the subject of rigor in the study of amyloid ...


Author: Natsumi Ageta-Ishihara Background: In autosomal recessive early-onset Parkinsonism (PARK2), the pathogenetic process from the loss of function of a ubiquitin ligase parkin to the death of dopamine neurons remains unclear. A dominant hypothesis attributes the neurotoxicity to accumulated substrates that are exempt from parkin-mediated degradation. Parkin substrates include two […]

Chronic overload of SEPT4, a parkin substrate that aggregates in ...



Author: Pratap Karki Manganese (Mn) is an essential element that is required in trace amount for normal growth, development as well maintenance of proper function and regulation of numerous cellular and biochemical reactions. Yet, excessive Mn brain accumulation upon chronic exposure to occupational or environmental sources of this metal may […]

Manganese Neurotoxicity: a Focus on Glutamate Transporters


Author: Naomi P Visanji Parkinson’s disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The progression of parkinsonian pathology and clinical phenotype has been broadly demonstrated to follow a specific pattern, most notably described by Braak and colleagues. In more […]

The prion hypothesis in Parkinson's disease: Braak to the future



Author: Thi A Nguyen Background: Complex interactions involving genetic susceptibility and environmental factors are thought to underlie the pathogenesis of Parkinson’s disease (PD). Although the role of inflammatory processes in modulating risk for development of PD has yet to be fully understood, prospective studies suggest that chronic use of NSAIDs […]

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1-/- ...


Author: Xiao-dong Pan Frontotemporal lobar degeneration (FTLD) represents a group of clinically, neuropathologically and genetically heterogeneous disorders with plenty of overlaps between the neurodegenerative mechanism and the clinical phenotype. FTLD is pathologically characterized by the frontal and temporal lobar atrophy. Frontotemporal dementia (FTD) clinically presents with abnormalities of behavior and […]

Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review



Author: Shahrul Azmin Background: Dengue is a common illness in the tropics. Equally common are neurological complications that stem from dengue infection. However, to date, parkinsonism following dengue has not been reported in medical literature.Case presentationA previously well 18-year old man developed parkinsonism, in addition to other neurological symptoms following […]

Post-dengue parkinsonism


Author: Amanda N Sacino Parkinson’s disease, the most common movement disorder, results in an insidious reduction for patients in quality of life and ability to function. A hallmark of Parkinson’s disease is the brain accumulation of neuronal cytoplasmic inclusions comprised of the protein alpha-synuclein. The presence of alpha-synuclein brain aggregates […]

Does a prion-like mechanism play a major role in the ...



Author: Li Zhou We demonstrate for the first time that the genome-wide profiling of HIV-infected peripheral blood mononuclear cells (PBMCs) from HIV-patients free of neurologic disease show overrepresentation of neurodegenerative pathways (Alzheimer’s, Parkinson’s, ALS, Huntington’s and Prion Disease, etc.) in genome-wide microarray analysis, which suggests that this genome-wide representation of […]

Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected ...


Author: Youpei Wang Background: Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated withParkinson disease (PD) in various ethnic populations such as Singaporean, Japanese,Formosan, Canadian, American, Portuguese, Greek, Brazilian, British, Italian, AshkenaziJewish, southern and southwestern Chinese. The purpose of this study is to determine incentral China whether or not […]

Glucocerebrosidase L444P mutation confers genetic risk for Parkinson's disease in central ...



Author: Youpei Wang Background: Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated withParkinson disease (PD) in various ethnic populations such as Singaporean, Japanese,Formosan, Canadian, American, Portuguese, Greek, Brazilian, British, Italian, AshkenaziJewish, southern and southwestern Chinese. The purpose of this study is to determine incentral China whether or not […]

Glucocerebrosidase L444P mutation confers genetic risk for Parkinson's disease in central ...