Respiratory System


Author: Thuc T Le Background: Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcoholic fatty liver disease. Prevention of tamoxifen-induced fatty liver has the potential to improve […]

Uridine prevents tamoxifen-induced liver lipid droplet accumulation


Author: Stefano Stagi Background: A higher prevalence of coeliac disease (CD) has been reported in patients with Williams-Beuren syndrome (WBS), though coexistence with other autoimmune diseases has not been evaluated.ObjectiveThe aim of this study was to examine the prevalence of the more frequent autoimmune diseases and organ- and non-organ specific […]

Coeliac disease and risk for other autoimmune diseases in patients ...



Author: Boon K Yeo Background: The use of foot orthoses and in-shoe wedges in cycling are largely based on theoretical benefits and anecdotal evidence. This review aims to systematically collect all published research on this topic, critically evaluate the methodology and summarise the findings. Methods: Study inclusion criteria were: all […]

The effect of foot orthoses and in-shoe wedges during cycling: ...


Author: Andréa S Almeida Spatial heterogeneity in the incidence of visceral leishmaniasis (VL) is an important aspect to be considered in planning control actions for the disease. The objective of this study was to predict areas at high risk for visceral leishmaniasis (VL) based on socioeconomic indicators and remote sensing […]

Prediction of high-risk areas for visceral leishmaniasis using socioeconomic indicators ...



Author: Ning Wen Background: The Forkhead box M1 (FOXM1), an important regulator of cell differentiation and proliferation, is overexpressed in a number of aggressive human carcinomas. The purpose of this study was to examine the expression levels of FOXM1 in epithelial ovarian cancer (EOC), to identify the relationship between FOXM1 […]

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell ...


Author: Antonia Efstathiou Background: In search of new antiparasitic agents for overcoming the limitations of current leishmaniasis chemotherapy, we have previously shown that 6-bromoindirubin-3[prime]-oxime (6-BIO) and several other 6-substituted analogues of indirubin, a naturally occurring bis-indole present in mollusks and plants, displayed reverse selectivity from the respective mammalian kinases, targeting […]

An inhibitor-driven study for enhancing the selectivity of indirubin derivatives ...



Author: Thomas Mücke Background: The evidence base to inform the decision making process in patients with early stage oral cancer and a clinical and radiological N0 neck remains insufficient to answer the question when it is safe to "watch and wait" and when to proceed with a selective neck dissection. […]

Incidence and outcome for patients with occult lymph node involvement ...


Author: Paulino Barragán-Iglesias Background: The participation of spinal P2X receptors in pain neuropathic is well recognized. However, the role of P2Y receptors has been less studied. The purpose of this study was to investigate the contribution of spinal P2Y6,11 receptors following peripheral nerve damage induced by spinal nerve ligation. In […]

Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain ...



Author: Qiuan Zhong Background: Body mass index (BMI) and hemoglobin (Hb) are positively associated with hypertensive disorders among pregnant women. The aim of this study was to estimate a potential interaction between high BMI and high Hb concentrations on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in pregnancy. […]

Interaction of body mass index and hemoglobin concentration on blood ...


Author: Kaoru Kaseda Solitary papilloma of the lung is thought to be a rare benign epithelial tumor, and complete surgical resection is currently the standard treatment for this pathology. However, some cases of papilloma have reportedly shown malignant potential. We report two cases of solitary glandular papilloma of the peripheral […]

Solitary glandular papilloma of the peripheral lung: a report of ...



Author: Martin Sokol Background: Insertional mutagenesis screens of retrovirus-induced mouse tumors have proven valuable in human cancer research and for understanding adverse effects of retroviral-based gene therapies. In previous studies, the assignment of mouse genes to individual retroviral integration sites has been based on close proximity and expression patterns of […]

Novel principles of gamma-retroviral insertional transcription activation in murine leukemia ...


Author: Katie R Robinson Background: Chair based exercise (CBE) is suggested to engage older people with compromised health and mobility in an accessible form of exercise. A systematic review looking at the benefits of CBE for older people identified a lack of clarity regarding a definition, delivery, purpose and benefits. […]

Developing the principles of chair based exercise for older people: ...



Author: Yan-Li Li Background: Despite the use of modern immunochemotherapy regimens, a significant proportion of diffuse large B-cell lymphoma (DLBCL) patients will relapse. We proposed absolute lymphocyte count/absolute monocyte count ratio (ALC/AMC ratio) as a new prognostic factor in relapsed or primary refractory DLBCL. Methods: We retrospectively analyzed 163 patients […]

Peripheral blood lymphocyte/monocyte ratio at the time of first relapse ...


Author: Simon Menanteau-Ledouble Background: Aeromonas salmonicida is an important fish pathogen that produces a wide and varied array of virulence factors. Here we used iron deprivation by addition of the chelator 2’2-dipyridyl to induce the expression of several such virulence factors in three isolates of Aeromonas salmonicida (one avirulent and […]

Protein expression and transcription profiles of three strains of Aeromonas ...



Author: Jing Zhao Background: The novel Femtosecond lenticule extraction (FLEx) procedure has been considered safe, predictable, and effective in treating myopia and myopic astigmatism, with few complications. However, an enhancement procedure after FLEx may be required in some cases, but has not been reported in detail.Case presentationA 24-year-old woman who […]

Enhancement of femtosecond lenticule extraction for visual symptomatic eye after ...


Author: Hidetaka Noma Background: The association of inflammatory factors and the aqueous flare value with macular edema in branch retinal vein occlusion (BRVO) patients remains unclear. The relationship between the aqueous flare value and the vitreous fluid levels of vascular endothelial growth factor (VEGF), interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, […]

Role of Inflammation in Previously Untreated Macular Edema with Branch ...



Author: Mitsunori Higuchi Background: Video-assisted thoracic surgery (VATS) lobectomy is a standard treatment for lung cancer. This study retrospectively compared long-term outcomes after VATS lobectomy versus lobectomy via open thoracotomy for clinical stage IA non-small cell lung cancer (NSCLC). Methods: From July 2002 to June 2012, 160 patients were diagnosed […]

Long-term outcomes after video-assisted thoracic surgery (VATS) lobectomy versus lobectomy ...


Author: Rosario M Piro Background: Common approaches to pathway analysis treat pathways merely as lists of genes disregarding their topological structures, that is, ignoring the genes’ interactions on which a pathway’s cellular function depends. In contrast, PathWave has been developed for the analysis of high-throughput gene expression data that explicitly […]

Network topology-based detection of differential gene regulation and regulatory switches ...



Author: Sonia Shah Background: HIV-1 gene expression is driven by the long terminal repeat (LTR), which contains many binding sites shown to interact with an array of host and viral factors. Selective pressures within the host as well as the low fidelity of reverse transcriptase lead to changes in the […]

Functional properties of the HIV-1 long terminal repeat containing single-nucleotide ...


Author: Johannes Thome Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This "progress" of molecular psychiatry, however, is to a degree "unilateral" and "epiphytic" should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of […]

Decennium of Karl Jaspers's general psychopathology: implications for molecular psychiatry



Author: Gaute Reier Jenssen Background: Public awareness of hemolytic-uremic syndrome (HUS), especially related to Shiga toxin producing Escherichia coli (STEC), has increased in Europe in recent years; accentuated in Norway by a national outbreak in 2006 and in a European context especially by the 2011 outbreak originating in Germany. As […]

Incidence and etiology of hemolytic-uremic syndrome in children in Norway, ...


Author: Nilimesh Halder Background: A vaccine matched to a newly emerged pandemic influenza virus would require a production time of at least 6 months with current proven techniques, and so could only be used reactively after the peak of the pandemic. A pre-pandemic vaccine, although probably having lower efficacy, could […]

A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness



Author: Kristin Pogoda Background: Gap junctional calcium signal propagation (transfer of calcium or a calcium releasing messenger via gap junctions) between vascular cells has been shown to be involved in the control of vascular tone. We have shown before that nitric oxide (NO) inhibits gap junctional communication in HeLa cells […]

NO, via its target Cx37, modulates calcium signal propagation selectively ...


Author: Jitendra Kanodia Background: The Fibroblast Growth Factor (FGF) pathway is driving various aspects of cellular responses in both normal and malignant cells. One interesting characteristic of this pathway is the biphasic nature of the cellular response to some FGF ligands like FGF2. Specifically, it has been shown that phenotypic […]

Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic ...