Integumentary System


Author: Punita Bhansali Background: Proper binocular vision depends on the routing at the optic chiasm of the correct proportion of retinal ganglion cell (RGC) axons that project to the same (ipsilateral) and opposite (contralateral) side of the brain. The ipsilateral RGC projection is reduced in mammals with albinism, a congenital […]

Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion ...


Author: Yanjiao Zhou Background: Determining bacterial abundance variation is the first step in understanding bacterial similarity between individuals. Categorization of bacterial communities into groups or community classes is the subsequent step in describing microbial distribution based on abundance patterns. Here, we present an analysis of the groupings of bacterial communities […]

Exploration of bacterial community classes in major human habitats



Author: Dario Coletti In tissues characterized by a high turnover or following acute injury, regeneration replaces damaged cells and is involved in adaptation to external cues, leading to homeostasis of many tissues during adult life. An understanding of the mechanics underlying tissue regeneration is highly relevant to regenerative medicine-based interventions. […]

Restoration versus reconstruction: cellular mechanisms of skin, nerve and muscle ...


Author: Nathalie Accart Background: Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalance the Th2-immunosuppressive state associated with this pathology. In a phase I/II clinical trial, we correlated the local immune […]

Lymphocitic infiltration in the cutaneous lymphoma microenvironment after injection of ...



Author: Paolo Durando Background: The screening of both healthcare workers and students attending teaching hospitals for latent tuberculosis infection (LTBI) is recommended in hospitals of many countries with a low-incidence of TB, including Italy, as a fundamental tool of tuberculosis (TB) control programs. The aim of the study was to […]

Latent tuberculosis infection and associated risk factors among undergraduate healthcare ...


Author: Yu-fei Lin Background: Sequencing of the genome of Propionibacterium acnes produced a catalogue of genes many of which enable this organism to colonise skin and survive exposure to the elements. Despite this platform, there was little understanding of the gene regulation that gives rise to an organism that has […]

A combination of improved differential and global RNA-seq reveals pervasive ...



Author: Jiazhou Wang Background: Accurate target localization is mandatory in the accelerated partial breast irradiation (APBI) delivery. Dosimetric verification for positional error will further guarantee the accuracy of treatment delivery. The purpose of this study is to evaluate the clinical feasibility of a cone beam computer tomographic (CBCT) image correction […]

Using corrected Cone-Beam CT image for accelerated partial breast irradiation ...


Author: Roei D Mazor Erdheim-Chester Disease (ECD) is a rare form of non Langerhans’ cell histiocytosis. Individuals affected by this disease are typically adults between their 5th and 7th decades of life. Males and females are almost equally affected. The multi systemic form of ECD is associated with significant morbidity, […]

Erdheim-Chester Disease: a comprehensive review of the literature



Author: Charlotte Leboeuf-Yde Background: It was previously assumed that low back pain (LBP) is a disorder that can be classified as acute, subacute and chronic. Lately, the opinion seems to have veered towards a concept of it being a more recurrent or cyclic condition. Interestingly, a recent review of the […]

Evidence-based classification of low back pain in the general population: ...




Author: Paolo Bifulco Background: Electrosurgery units are widely employed in modern surgery. Advances in technology have enhanced the safety of these devices, nevertheless, accidental burns are still regularly reported. This study focuses on possible causes of sacral burns as complication of the use of electrosurgery. Burns are caused by local […]

Investigating the role of capacitive coupling between the operating table ...


Author: Emma Leire Background: Hypoxia inducible factor-1 (HIF-1) is a major regulator of the cellular adaption to low oxygen stress and the innate immune function of myeloid cells. Treatment with the novel HIF-1 stabilizing drug AKB-4924 has been shown to enhance the bactericidal activity of keratinocytes as well as phagocytic […]

Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and ...



Author: Chang-Hoon Lee Background: The aim of this study was to determine the prevalence rate of latent TB infection (LTBI) and active TB among homeless in Seoul metropolitan city, South Korea, and to compare the TB burden among homeless people with that of a control group. Methods: The homeless participants […]

Active pulmonary tuberculosis and latent tuberculosis infection among homeless people ...


Author: Christian Agrillo Background: A significant debate surrounds the nature of the cognitive mechanisms involved in non-symbolic number estimation. Several studies have suggested the existence of the same cognitive system for estimation of time, space, and number, called "a theory of magnitude" (ATOM). In addition, researchers have proposed the theory […]

Individual differences in non-symbolic numerical abilities predict mathematical achievements but ...



Author: Jun Wang Background: Recently, melanoma has become the most malignant and commonly occurring skin cancer. Melanoma is not only the major source (75%) of deaths related to skin cancer, but also it is hard to be treated by the conventional drugs. Recent research indicated that angiogenesis is an important […]

Multi-scale agent-based modeling on melanoma and its related angiogenesis analysis


Author: Katja Warm Background: Studies on time trends of allergic sensitization among adults are rare. The aim of the study was to compare the prevalence of allergic sensitization to common airborne allergens among adults 15 years apart and to identify risk factors for allergic sensitization. Methods: Clinical examinations including skin […]

Increase in sensitization to common airborne allergens among adults — ...



Author: Robert Koprowski Background: Efficacy and safety of various treatments using fractional laser or radiofrequency depend, to a large extent, on precise movement of equipment head across the patient’s skin. In addition, they both depend on uniform distribution of emitted pulses throughout the treated skin area. The pulses should be […]

Image analysis and processing methods in verifying the correctness of ...


Author: Marco Barbero Background: Myofascial trigger points (MTrPs) are hyperirritable spots located in taut bands of muscle fibres. Electrophysiological studies indicate that abnormal electrical activity is detectable near MTrPs. This phenomenon has been described as endplate noise and it has been purported to be associated MTrP pathophysiology. Thus, it is […]

Myofascial trigger points and innervation zone locations in upper trapezius ...



Author: Liya Wassie Background: M. tuberculosis remains one of the world’s deadliest pathogens in part because of its ability to establish persistent, latent infections, which can later reactivate to cause disease. In regions of the globe where disease is endemic, as much as 50% of the population is thought to […]

Parasitic infection may be associated with discordant responses to QuantiFERON ...


Author: Nigatu Kebede Background: Leishmaniasis is a clinically and epidemiologically diverse zoonotic disease caused by obligatory, intracellular protozoan parasites of the genus Leishmania. Cutaneous leishmaniasis is the most widely distributed form of the disease characterized by skin lesions. Leishmania aethiopica is considered the predominant etiological agent in Ethiopia. The current […]

Multilocus microsatellite signature and identification of specific molecular markers for ...



Author: Tony Sheehy Background: To determine the portion sizes of traditional and non-traditional foods being consumed by Inuit adults in three remote communities in Nunavut, Canada. Methods: A cross-sectional study was carried out between June and October, 2008. Trained field workers collected dietary data using a culturally appropriate, validated quantitative […]

Eating habits of a population undergoing a rapid dietary transition: ...


Author: Mounia Serraj Mature teratoma is the most common primary germ cell tumor in the mediastinum. On rare occasions, cystic teratomas rupture in adjacent structures, such as pleural space, pericardium, lung or tracheobronchial tree. We present a case of a mediastinal mature cystic teratoma in 16-year-old female with complex rupture […]

Mediastinal mature teratoma with complex rupture into the lung, bronchus ...



Author: Manuel J Coelho-e-Silva Background: Sex and individual differences in biological maturity status can influence height, weight, and body fat. Thus, the rigorous control of these variables seems necessary for estimating overweight and obesity in adolescents. The aims of this study were to estimate the prevalence of overweight and obesity […]

Nutritional status, biological maturation and cardiorespiratory fitness IN Azorean youth ...


Author: James M Mason Background Parents and carers of children with eczema often underuse emollient therapy, essential to repairing and protecting the defective skin barrier in atopic eczema. Educational interventions delivered by specialist dermatology nurses in hospital settings have been shown to improve emollient use and reduce symptoms of atopic […]

Improved emollient use reduces atopic eczema symptoms and is cost ...