Stroke


Author: Christopher D Maroules Background: Cardiovascular magnetic resonance (CMR) has been validated for the noninvasive assessment of total arterial compliance and aortic stiffness, but their associations with cardiovascular outcomes is unknown. The purpose of this study was to evaluate associations of CMR measures of total arterial compliance and two CMR […]

Cardiovascular outcome associations among cardiovascular magnetic resonance measures of arterial ...


Author: James P Sheppard Background: As the first point of contact for patients and witnesses of stroke, General Practice receptionists can be instrumental in deciding the urgency of clinical contact. Despite the considerable complexity of this task, reception staff are not clinically trained. Minimising the time taken to access thrombolysis […]

Receptionist rECognition and rEferral of patients with stroke (RECEPTS) study ...



Author: Yu Ye Background: The aim of this study is to investigate quantitative outcome measurements of hand motor performance for subjects after mild to moderate stroke using grip control tasks and characterize abnormal flexion synergy of upper extremities after stroke. Methods: A customized dynamometer with force sensors was used to […]

Kinetic measurements of hand motor impairments after mild to moderate ...


Author: Nadim Anani Background: Providing scalable clinical decision support (CDS) across institutions that use different electronic health record (EHR) systems has been a challenge for medical informatics researchers. The lack of commonly shared EHR models and terminology bindings has been recognised as a major barrier to sharing CDS content among […]

Retrospective checking of compliance with practice guidelines for acute stroke ...



Author: Carina U Persson Background: A frequently used clinical test to assess mobility after stroke is the Timed Up & Go. Knowledge regarding whether or not the Timed Up & Go is able to detect change over time in patients with stroke, whether improvements in mobility exist after the first […]

Timed up & go as a measure for longitudinal change ...


Author: Joanne Woodford Background: Increased life expectancy has resulted in a greater provision of informal care within the community for patients with chronic physical health conditions. Informal carers are at greater risk of poor mental health, with one in three informal carers of stroke survivors experiencing depression. However, currently no […]

Supported cognitive-behavioural self-help versus treatment-as-usual for depressed informal carers of ...



Author: Yu Zhou Background: The treatment of large(10-25 mm) or giant(>=25 mm) cerebral aneurysms remains technically challenging, with a much higher complication and recanalization rate than that is observed for smaller aneurysms. The use of a flow diverter seems to facilitate the treatment of this special entity. In a previous […]

Parent artery reconstruction for large or giant cerebral aneurysms using ...


Author: Rose Galvin Background: The ABCD2 clinical prediction rule is a seven point summation of clinical factors independently predictive of stroke risk. The purpose of this cohort study is to validate the ABCD2 rule in a Bulgarian hospital up to three years after TIA. Methods: All consecutive admissions to an […]

Long-term risk of stroke after transient ischaemic attack: a hospital-based ...



Author: Paolo Gardois Background: Stroke places a significant burden to all affected individuals, but it is perhaps more significant amongst members of black, minority and ethnic communities, who may experience poorer awareness of stroke symptoms than the general population. Recently, several initiatives tried to improve public awareness that symptoms of […]

Health promotion interventions for increasing stroke awareness in ethnic minorities: ...


Author: Jun Lu Mitochondrial dysfunction manifests in many forms during childhood. There is no effective therapy for the condition; hence symptomatic therapy is the only option. The effect of symptomatic therapy are not well known. We present clinical course, diagnosis and effect of current treatments for six children suffering from […]

Childhood mitochondrial encephalomyopathies: clinical course, diagnosis, neuroimaging findings, mtDNA mutations ...



Author: Jia Liu Human induced pluripotent stem cells (iPSCs) have attracted increasing interest in the field of ischemic stroke therapy, due to the lack of ethical concerns and reduced risk of immune rejection. However, the safety and efficiency of the donor iPSC derivates in the ischemic brain challenged the therapeutic […]

Induced pluripotent stem cell-derived neural stem cells: new hope for ...


Author: Mohammed Al-Jaghbeer Background: The hemoglobin threshold for transfusion of red blood cells in patients with acute gastrointestinal (GI) bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy. Methods: Objective: The objective was to prove that the restrictive […]

Blood transfusion for upper gastrointestinal bleeding: is less more again?



Author: Flávia P Junqueira Background: Patients with Sickle cell disease (SCD) who receive regular transfusions are at risk for developing cardiac toxicity from iron overload. The aim of this study was to assess right and left cardiac volumes and function, late gadolinium enhancement (LGE) and iron deposits in patients with […]

Right and left ventricular function and myocardial scarring in adult ...


Author: Andrea Polito IntroductionSepsis-associated brain dysfunction has been linked to white matter lesions (leucoencephalopathy) and ischemic stroke. Our objective was to assess the prevalence of brain lesions in septic shock patients requiring magnetic resonance imaging (MRI) for an acute neurological change.MethodSeventy-one septic shock patients were included in a prospective observational […]

Pattern of brain injury in the acute setting of human ...



Author: Nina Vindegaard Grønberg Stroke is one of the leading causes of death worldwide. At present, the only available treatment is thrombolysis, which should be initiated no later than 4.5 hours after onset of symptoms. Several studies have shown that an attenuation of the inflammatory response in relation to stroke […]

Leukocyte infiltration in experimental stroke


Author: Sangita Sharma Background: Stroke is the fourth leading cause of death in the U.S. and stroke mortality rates differ substantially by ethnic group. The impact of adherence to the USDA dietary guidelines on risk for fatal stroke among different ethnic groups has not previously been examined. Methods: A prospective […]

Adherence to the USDA dietary recommendations for fruit and vegetable ...



Author: Sheetal Bodhankar Background: Stroke severity is worsened by recruitment of inflammatory immune cells into the brain. This process depends in part on T cell activation, in which the B7 family of co-stimulatory molecules plays a pivotal role. Previous studies demonstrated more severe infarcts in mice lacking programmed death-1 (PD-1), […]

PD-L1 enhances CNS inflammation and infarct volume following experimental stroke ...


Author: Seth Uretsky Background: The systolic variation of mitral regurgitation (MR) is a pitfall in its quantification. Current recommendations advocate using quantitative echocardiographic techniques that account for this systolic variation. While prior studies have qualitatively described patterns of systolic variation no study has quantified this variation. Methods: This study includes […]

A novel technique to quantify the instantaneous mitral regurgitant rate



Author: Gabriel R Cojocaru Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular system affect both directly and indirectly the function in a variety of organs, including the brain, with consequent neurological (motor and sensory performance) and cognitive impairments, as well as leading […]

Post-stroke depression and the aging brain


Author: David James Clarke Background: Medical Research Council (MRC) guidance identifies implementation as a key element of the development and evaluation process for complex healthcare interventions. Implementation is itself a complex process involving the mobilization of human, material, and organizational resources to change practice within settings that have pre-existing structures, […]

Implementing a training intervention to support caregivers after stroke: a ...



Author: Nahal Mavaddat Background: Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke survivors has received little attention compared to that in other older individuals. This study identifies determinants of self-rated […]

What determines the self-rated health of older individuals with stroke ...


Author: Johan Engdahl Background: In a screening study for silent atrial fibrillation (AF), which is a frequent source of cardiac emboli with ischemic stroke, the proportion of non-participants was considerable and their clinical profile differed from the participants’ profile. We intended to geo-map the target population and non-participation in an […]

Uptake of atrial fibrillation screening aiming at stroke prevention: geo-mapping ...



Author: Marieke M Visser Background: Coping style is one of the determinants of health-related quality of life after stroke. Stroke patients make less use of active problem-oriented coping styles than other brain damaged patients. Coping styles can be influenced by means of intervention. The primary aim of this study is […]

The effectiveness of problem solving therapy for stroke patients: study ...


Author: Hannes G Kenngott Background: Type 2 diabetes mellitus (T2DM) is a disease with high prevalence, associated with severe co-morbidities as well as being a huge burden on public health. It is known that glycemic control decreases long-term morbidity and mortality. The current standard therapy for T2DM is medical treatment. […]

DiaSurg 2 trial – surgical vs. medical treatment of insulin-dependent ...