Ulcerative Colitis


Author: Nikolai V Kuznetsov Background: Glucocorticoids (GCS) remain one of the mainstay treatments in the management of ulcerative colitis (UC) but up to a third of patients will ultimately fail to respond and progress to a more severe and difficult to manage disease state. Previous clinical studies suggest that the […]

Biomarkers can predict potential clinical responders to DIMS0150 a toll-like ...


Author: Masaki Ujihara Background: Ulcerative colitis (UC) often occurs in women of childbearing age. Compared to Western countries, however, few studies have investigated the impact of UC on the progress of pregnancy in Asian populations. Methods: We retrospectively examined 91 pregnancies in 64 patients with UC experienced at our hospital […]

Importance of appropriate pharmaceutical management in pregnant women with ulcerative ...



Author: James Yoo Background: Enhanced EGF receptor (EGFR) signaling is a hallmark of many human cancers, though the role of enhanced EGFR signaling within the surrounding tumor stroma has not been well studied. The myofibroblast is an important stromal cell that demonstrates enhanced EGFR expression in the setting of inflammation, […]

TNF-alpha and LPA promote synergistic expression of COX-2 in human ...


Author: Lucia Caminiti Food protein-induced enterocolitis syndrome (FPIES) is an uncommon and potentially severe non IgE-mediated gastrointestinal food allergy. It is usually caused by cow’s milk or soy proteins, but may also be triggered by ingestion of solid foods. The diagnosis is made on the basis of clinical history and […]

Food protein induced enterocolitis syndrome caused by rice beverage



Author: Jayakanthan Kabeerdoss Background: Alterations in the fecal bacterial flora occur in inflammatory bowel disease (IBD). We examined the abundance and diversity of Clostridium leptum group, an important group of carbohydrate-fermenting bacteria, in the feces of patients with IBD and compared them with healthy controls. Methods: Seventeen healthy controls (HC), […]

Clostridium leptum group bacteria abundance and diversity in the fecal ...


Author: Elaine O Petrof Background: Fecal bacteriotherapy (‘stool transplant’) can be effective in treating recurrent Clostridium difficile infection, but concerns of donor infection transmission and patient acceptance limit its use. Here we describe the use of a stool substitute preparation, made from purified intestinal bacterial cultures derived from a single […]

Stool substitute transplant therapy for the eradication of <it>Clostridium difficile</it> ...



Author: Hui-qing Lv Background: Our study aims to determine whether response surface methodology can optimize the extraction of dietary fiber from Maixiansan. Methods: A Box–Behnken design was employed to optimize the extraction parameters, including alpha-amylase concentration (X1: 0.3 — 0.5%), enzymolysis time (X2: 30 — 60 min) and NaOH content […]

Optimization of technology for dietary fiber extraction from Maixiansan by ...


Author: Giuseppe Esposito Background: Intestinal inflammation is partly driven by enteroglial-derived S100B protein. The antiprotozoal drug pentamidine directly blocks S100B activity. We aimed to investigate the effect of pentamidine on intestinal inflammation using an animal model of dextran sodium sulphate (DSS)-induced acute colitis. Methods: Mice were divided into: control group, […]

The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in ...