Vascular Disease


Author: Christopher D Maroules Background: Cardiovascular magnetic resonance (CMR) has been validated for the noninvasive assessment of total arterial compliance and aortic stiffness, but their associations with cardiovascular outcomes is unknown. The purpose of this study was to evaluate associations of CMR measures of total arterial compliance and two CMR […]

Cardiovascular outcome associations among cardiovascular magnetic resonance measures of arterial ...


Author: Nathan R Hill Background: Chronic kidney disease (CKD) is common and increasing in prevalence. Cardiovascular disease (CVD) is a major cause of morbidity and death in CKD, though of a different phenotype to the general CVD population. Few therapies have proved effective in modifying the increased CVD risk or […]

Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK ...



Author: Bernard G Jaar Background: This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics. Methods: We performed a cross-sectional analysis in the Predictors of Arrhythmic and Cardiovascular Events in End-Stage Renal Disease (PACE) […]

Incidental findings on cardiac computed tomography in incident hemodialysis patients: ...


Author: Christos G Kostopoulos Background: Depending on their anatomical location, different fat depots have a different capacity to produce bioactive peptides, called adipokines. Adipokines produced by periadventitial fat have been implicated in the pathogenesis of vascular disease, including atherosclerosis. Chemerin is an adipokine with an established role in immunity, adipose […]

Chemerin and CMKLR1 expression in human arteries and periadventitial fat: ...



Author: Nahla Khamis Ibrahim Background: Nowadays, Cardiovascular Diseases (CVDs) represents an escalating worldwide public health problem. Providing consistent data on the magnitude and risk factors of CVDs among young population will help in controlling the risks and avoiding their consequences.ObjectiveThe objective was to estimate the prevalence of risk factors of […]

Risk factors of coronary heart disease among medical students in ...


Author: Sophie Liabeuf Background: Matrix Gla protein (MGP) is an important inhibitor of calcification. The objective of the present study of patients with type 2 diabetes and normal or slightly altered kidney function was to evaluate levels of inactive, dephospho-uncarboxylated MGP(dp-ucMGP) and total uncarboxylated MGP(t-ucMGP) and assess their links with […]

Vascular calcification in patients with type 2 diabetes: the involvement ...



Author: Mohammed Al-Jaghbeer Background: The hemoglobin threshold for transfusion of red blood cells in patients with acute gastrointestinal (GI) bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy. Methods: Objective: The objective was to prove that the restrictive […]

Blood transfusion for upper gastrointestinal bleeding: is less more again?


Author: Xinqing Deng Background: Magnesium plays an essential role in the synthesis and metabolism of vitamin D and magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent vitamin-D-resistant rickets. We hypothesized that dietary magnesium alone, particularly its interaction with vitamin D intake, contributes to serum […]

Magnesium, vitamin D status and mortality: results from US National ...



Author: Jadwiga A Wedzicha Exacerbations of chronic obstructive pulmonary disease (COPD) are important events that carry significant consequences for patients. Some patients experience frequent exacerbations, and are now recognized as a distinct clinical subgroup, the ‘frequent exacerbator’ phenotype. This is relatively stable over time, occurs across disease severity, and is […]

Mechanisms and impact of the frequent exacerbator phenotype in chronic ...


Author: Zahra Bahadoran In recent years, there is growing evidence that plant-foods polyphenols, due to their biological properties, may be unique nutraceuticals and supplementary treatments for various aspects of type 2 diabetes mellitus. In this article we have reviewed the potential efficacies of polyphenols, including phenolic acids, flavonoids, stilbenes, lignans […]

Dietary polyphenols as potential nutraceuticals in management of diabetes: a ...



Author: Raquel C Gardner The population of oldest old, or people aged 85 and older, is growing rapidly. A better understanding of dementia in this population is thus of increasing national and global importance. In this review, we describe the major epidemiological studies, prevalence, clinical presentation, neuropathological and imaging features, […]

Dementia in the oldest old: a multi-factorial and growing public ...


Author: Júlio César de Oliveira Background: Chronic obstructive pulmonary disease (COPD) is an important public health issue in many countries which is estimated to become the fifth cause of disability and the third cause of mortality in the world within 2020.The objective of this study was to identify the clinical […]

Clinical significance in COPD patients followed in a real practice



Author: Michael R Preusch Background: The cytokine growth differentiation factor-15 (GDF-15), a member of the TGF beta superfamily, has recently been discovered to play an important role in cardiovascular diseases. It is mostly expressed in macrophages of atherosclerotic lesions, but its impact on advanced atherosclerosis is still unknown. This study […]

GDF-15 protects from macrophage accumulation in a mousemodel of advanced ...


Author: Kai-Hang Yiu ObjectiveType 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism is uncertain. We postulated that arterial stiffness, endothelial dysfunction and subclinical atherosclerosis may contribute to subclinical myocardial injury in patients with T2DM. Methods: Serum high-sensitivity troponin I (hs-TNI) an indicator of myocardial […]

Association of subclinical myocardial injury with arterial stiffness in patients ...



Author: Hirofumi Nagao Background: Although many Asian type 2 diabetic patients have been considered to be not obese and have low capacity of insulin secretion, the proportion of obese patients with visceral fat accumulation has increased in recent years. We found previously considerable number of Japanese non-obese subjects (body mass […]

Vascular complications and changes in body mass index in Japanese ...


Author: Mark F Harris Background: Despite being at high risk, disadvantaged patients may be less likely to receive preventive care in general practice. This study aimed to explore self-reported preventive care received from general practitioners and the factors associated with this by healthy New South Wales (NSW) residents aged 45–74 […]

Preventive care in general practice among healthy older New South ...



Author: Panagiotis Pateinakis Background: Cardiovascular morbidity and mortality remains excessive in patients with chronic kidney disease. The association of vascular changes with regulators of extraosseous calcification in this patient population is still under investigation. The aim of the present study was to investigate the associations of the calcification inhibitor fetuin-A, […]

Associations of fetuin-A and osteoprotegerin with arterial stiffness and early ...


Author: Børge Moe Background: Physical activity has been associated with lower cardiovascular mortality in people with diabetes, but how diabetes severity influence this association has not been extensively studied. Methods: We prospectively examined the joint association of diabetes severity, measured as medical treatment status and disease duration, and physical exercise […]

Diabetes severity and the role of leisure time physical exercise ...



Author: Francisco Javier Félix-Redondo Background: To estimate the prevalence of overweight and obesity in the Spanish population as measured with body mass index (BMI), waist circumference (WC) and waist to height ratio (WHtR) and to determine the associated cardiovascular risk factors. Methods: Pooled analysis with individual data from 11 studies […]

Prevalence of obesity and associated cardiovascular risk: the DARIOS study


Author: Maie Alshahid Background: The muscle Ras (MRAS) gene resides on chromosome 3q22.3 and encodes a member of the membrane-associated Ras small GTPase proteins, which function as signal transducers in multiple processes including cell growth and differentiation. Its role in cardiovascular disease is not fully understood yet. In a preliminary […]

New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3




Author: Renata Micha Dietary guidelines emphasize selecting lean (low-fat) meats to reduce saturated fat and cholesterol, but growing evidence suggests that health effects may relate to other ingredients, such as sodium, heme iron, or L-carnitine. Understanding how meats influence health, and on which nutrients this relationship depends, is essential to […]

Processing of meats and cardiovascular risk: time to focus on ...



Author: Chun-Guang Ren Background: The aberrant activation of Ras signaling is associated with human diseases including hematological malignancies and vascular disorders. So far the pathological roles of activated Ras signaling in hematopoiesis and vasculogenesis are largely unknown. Methods: A conditional Cre/loxP transgenic strategy was used to mediate the specific expression […]

Activated N-Ras signaling regulates arterial-venous specification in zebrafish


Author: Cheng-Yu Chen Background: The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br., SZ) and Danshen (the root of Salvia miltiorrhiza […]

Antioxidant activity and components of a traditional chinese medicine formula ...