Vestibular Disorder


Author: Christian Cadeddu Background: Metformin (MET) therapy exerts positive effects improving glucose tolerance and preventing the evolution toward diabetes in insulin resistant patients. It has been shown that adding MET to exercise training does not improve insulin sensitivity. The aim of this study was to determine the effect of MET […]

Effects of metformin and exercise training, alone or in association, ...


Author: Jeffrey Shih-Chieh Chu Background: Essential genes are critical for the development of all organisms and are associated with many human diseases. These genes have been a difficult category to study prior to the availability of balanced lethal strains. Despite the power of targeted mutagenesis, there are limitations in identifying […]

High-throughput capturing and characterization of mutations in essential genes of ...



Author: Michelle Collinson Background: Around 150,000 people each year attend hospitals in England due to self-harm, many of them more than once. Over 5,000 people die by suicide each year in the UK, a quarter of them having attended hospital in the previous year because of self-harm. Self-harm is a […]

MIDSHIPS: Multicentre Intervention Designed for Self-Harm using Interpersonal Problem-Solving: protocol ...


Author: Hendrik CJ van Rensburg The purpose of this contribution is to analyse and explain the South African HRH case, its historical evolution, and post-apartheid reform initiatives aimed at addressing deficiencies and shortfalls. HRH in South Africa not only mirrors the nature and diversity of challenges globally, but also the […]

South Africa's protracted struggle for equal distribution and equitable access ...



Author: Adamu Addissie Background: Rapid Ethical Assessment (REA) is a form of rapid ethnographic assessment conducted at the beginning of research project to guide the consent process with the objective of reconciling universal ethical guidance with specific research contexts. The current study is conducted to assess the perceived relevance of […]

A mixed-methods study on perceptions towards use of Rapid Ethical ...


Author: Li-Feng Jiang-Xie Background: As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to dysfunctions of social cognition. Dlgap2, which encodes one of the main components of scaffold proteins in postsynaptic […]

Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and ...



Author: Lindsay B Baker Background: We developed a digital dietary analysis tool for athletes (DATA) using a modified 24-h recall method and an integrated, customized nutrient database. The purpose of this study was to assess DATA’s validity and relative validity by measuring its agreement with registered dietitians’ (RDs) direct observations […]

Validity and relative validity of a novel digital approach for ...


Author: Hiroko Komatsu Background: With a paradigm shift toward a chronic care model in cancer, the issue of adherence is becoming increasingly important in oncology. Methods: We mailed two self-reported surveys on current nursing practices for patients on oral chemotherapy to all 309 designated cancer centers and 141 large general […]

Current nursing practice for patients on oral chemotherapy: a multicenter ...



Author: Heather D Ritter Background: While glucocorticoids and the liganded glucocorticoid receptor (GR) have a well-established role in the maintenance of differentiation and suppression of apoptosis in breast tissue, the involvement of unliganded GR in cellular processes is less clear. Our previous studies implicated unliganded GR as a positive regulator […]

Expression microarray identifies the unliganded glucocorticoid receptor as a regulator ...


Author: Peter T Katzmarzyk Background: The primary aim of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE) was to determine the relationships between lifestyle behaviours and obesity in a multi-national study of children, and to investigate the influence of higher-order characteristics such as behavioural settings, and the […]

The International Study of Childhood Obesity, Lifestyle and the Environment ...



Author: R Preston Mason Background: Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebivolol-stimulated bioavailable NO are not fully understood. Methods: Using amperometric NO and peroxynitrite (ONOO-) nanosensors, beta3-receptor (agonist: […]

The favorable kinetics and balance of nebivolol-stimulated nitric oxide and ...


Author: Mike Van Diest Fall injuries are responsible for physical dysfunction, significant disability, and loss of independence among elderly. Poor postural control is one of the major risk factors for falling but can be trained in fall prevention programs. These however suffer from low therapy adherence, particularly if prevention is […]

Exergaming for balance training of elderly: state of the art ...



Author: Nathalie Accart Background: Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalance the Th2-immunosuppressive state associated with this pathology. In a phase I/II clinical trial, we correlated the local immune […]

Lymphocitic infiltration in the cutaneous lymphoma microenvironment after injection of ...


Author: Reynold Spector We and other investigators have postulated deterioration of essential choroid plexus (CP) functions in some elderly and especially Alzheimer’s disease patients based on apparent anatomical, histological and pathological changes in CP. We have termed this putative phenomenon CP failure. By focusing on four essential energy-requiring CP functions, […]

Sustained choroid plexus function in human elderly and Alzheimer's disease ...



Author: York Zausig IntroductionRecent data suggested an interaction between plasma constituents and the endothelial glycocalyx to be relevant for vascular barrier function. This might be negatively influenced by infusion solutions, depending on ionic composition, pH and binding properties. The present study evaluated such an influence of current artificial preparations. Methods: […]

The impact of crystalloidal and colloidal infusion preparations on coronary ...


Author: Lindsay Macdonald Background: Diabetes is a major health issue for individuals and for health services. There is a considerable literature on the management of diabetes and also on communication in primary care consultations. However, few studies combine these two topics and specifically in relation to nurse communication. This paper […]

Nurse-patient communication in primary care diabetes management: an exploratory study



Author: Elizabeth A Mann Background: Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates intracellular cGMP and is implicated in intestinal ion secretion, cell proliferation, apoptosis, intestinal barrier function, as […]

Guanylate cyclase C limits systemic dissemination of a murine enteric ...


Author: Alwin van Drongelen Background: A considerable percentage of flight crew reports to be fatigued regularly. This is partly caused by irregular and long working hours and the crossing of time zones. It has been shown that persistent fatigue can lead to health problems, impaired performance during work, and a […]

Development and evaluation of an intervention aiming to reduce fatigue ...



Author: Ryan M Smith Background: Measuring allelic RNA expression ratios is a powerful approach for detecting cis-acting regulatory variants, RNA editing, loss of heterozygosity in cancer, copy number variation, and allele-specific epigenetic gene silencing. Whole transcriptome RNA sequencing (RNA-Seq) has emerged as a genome-wide tool for identifying allelic expression imbalance […]

Whole transcriptome RNA-Seq allelic expression in human brain


Author: Hajime Ohmura Background: Training of young Thoroughbred horses must balance development of cardiopulmonary function and aerobic capacity with loading of the musculoskeletal system that can potentially cause structural damage and/or lameness. High-speed equine treadmills are sometimes used to supplement exercise on a track in the training of young Thoroughbreds […]

Physiological responses of young thoroughbred horses to intermittent high-intensity treadmill ...



Author: Amon Exavery Background: While severe shortages, inadequate skills and a geographical imbalance of health personnel have been consistently documented over the years as long term critical challenges in the health sector of the United Republic of Tanzania, there is limited evidence on the gender-based distribution of the health workforce […]

Gender-based distributional skewness of the United Republic of Tanzania's health ...


Author: Juan M Fernández-Alvira Background: It is well known that the prevalence of overweight and obesity is considerably higher among youth from lower socio-economic families, but there is little information about the role of some energy balance-related behaviors in the association between socio-economic status and childhood overweight and obesity. The […]

Parental education associations with children's body composition: mediation effects of ...



Author: Christian Stoppe Background: High costs still limits the widespread use of xenon in the clinical practice. Therefore, we evaluated xenon consumption of different delivery modes during general surgery. Methods: A total of 48 patients that underwent general surgery with balanced xenon anaesthesia were retrospectively analysed according to the mode […]

Xenon consumption during general surgery: a retrospective observational study


Author: Tao Du IntroductionBased on some well documented reports, we attempt to clarify the anti-fibrotic mechanisms of human Wharton’s-jelly derived mesenchymal stromal cells (WJ-MSCs) from the perspective of induction of hepatocyte growth factor (HGF) expression in tubular epithelial cells (TECs). Methods: A rat model of acute kidney injury (AKI) was […]

Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through ...